Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Described herein are DC-DC converters with electronic module cooling units used for air-convection cooling of some components of power electronic modules and conductive cooling of other components, e.g., switching sub-modules. A cooling unit may have a heat exchanger and a cooling plate, thermally coupled to one or more heat exchangers and one or more switching sub-modules. For example, the cooling plate can be positioned between and thermally coupled to heat exchangers. One fan can direct air through one heat exchanger and to one power electronic module as a part of convection cooling. An additional fan can direct air through the second heat exchanger and to the second power electronic module. The cooling plate can be also positioned between and thermally coupled to switching sub-modules of these power electronic modules thereby enabling conductive cooling. The plate-cooling liquid is pumped through the cooling plate.

Abstract: Techniques for generating healthcare form bundles with supplemental live image documentation are disclosed. The techniques include: obtaining, from a user, values of fields of a healthcare form; capturing a live image including supplemental documentation for the healthcare form, from a camera of a device operated by the user; generating a form bundle including (a) an electronic version of the healthcare form populated with the values, and (b) the image including the supplemental documentation for the healthcare form; and transmitting the form bundle to a healthcare organization.

Abstract: A system and method for thermoforming of non-woven fabric is presented. The system includes an air supply, a heating system in fluid communication with the air supply, a pressure and flow equalization element in fluid communication with the heating system, electrical controls in communication with the heating system and the pressure and flow equalization element, a pneumatic element in fluid communication with the pressure and flow equalization element, and a forming head for receiving a thermoformable non-woven fabric and for thermoforming said thermoformable non-woven fabric into a desired shape. The thermoforming process is a two-stage process, a first stage comprises a pre-heat stage wherein a heated flow of air is directed onto the thermoformable non-woven fabric and the second stage comprises flowing a continuous amount of air to increase an amount of heat available to the thermoformable non-woven fabric during thermoforming.

Abstract: Disclosed is an assist grip assembly including a handle portion and at least one support structure, the at least one support structure including a securing surface attached to a mounting area of a vehicle body, and a transfer member comprising a flex portion and a contact portion having a contact surface, wherein the transfer member is formed with or attached to the handle portion and when a load is applied to the handle portion in a first direction, the contact surface of the transfer member contacts a contact area of the vehicle body and transfers at least a portion of the load from the mounting area to the contact area.

Abstract: Disclosed is an assist grip assembly including a handle portion and at least one support structure, the at least one support structure including a securing surface attached to a mounting area of a vehicle body, and a transfer member comprising a flex portion and a contact portion having a contact surface, wherein the transfer member is formed with or attached to the handle portion and when a load is applied to the handle portion in a first direction, the contact surface of the transfer member contacts a contact area of the vehicle body and transfers at least a portion of the load from the mounting area to the contact area.

Abstract: A garnish assembly for an automotive pillar having a garnish dimensioned to cover the pillar and in which the garnish has a predetermined thickness and an elongated through slot. A spacer is disposed in the slot while a fastener extends through the spacer and is secured to the pillar. The spacer has a length at least as long as the predetermined thickness of the garnish and a cross-sectional shape smaller than the area of the slot so that the garnish is slidable relative to the spacer. The fastener may also be used to secure a handgrip to the pillar.

Abstract: An ejection control mechanism for a rail mount airbag is provided. The ejection control mechanism is comprised of an elongated strap attached to the rearwardmost cell of a side impact airbag. When the cell is inflated, the strap applies a tension to the cell in an upward and rearward direction and thereby assists the airbag in providing complete coverage of the motor vehicle side windows. One embodiment of the present invention is comprised of the strap being attached to the rearwardmost cell of the rail mounted airbag, whereas a second embodiment is comprised of the strap being attached to the rearwardmost cell and the motor vehicle frame.

Abstract: An energy absorbing mounting bracket for a rail mounted airbag inflator is provided. The mounting bracket has a circular section and at least one base leg. The circular section entraps an airbag inflator and the base leg is rigidly attached to the circular section and mounted to a vehicle rail. The base leg positions the circular section of the mounting bracket a specific distance from the rail, for the purpose of allowing the section to deflect in a direction towards the rail when an impact force is exerted on the section. One embodiment of the present invention is comprised of a circular section entrapping an airbag inflator and a first base leg, a second base leg and an intermediate leg. The first base leg is located adjacent to the vehicle rail when the bracket is mounted to the rail and is rigidly attached to the intermediate leg. The intermediate leg is rigidly attached to the circular section and the second base leg is also rigidly attached to said section.