Abstract: An asthma diagnosis and management system including a valved holding chamber defining an interior cavity, a backpiece having an opening configured to receive a pressurized metered dose inhaler and a user interface. A microphone is coupled to the valved holding chamber and is in communication with an interior of the valved holding chamber and is configured to capture a sound of a user's lungs.

Abstract: A valved holding chamber includes a holding chamber adapted to contain a substance and having an input end adapted to receive a dry powder inhaler, an output end and an interior volume defined between the input end and output end. An inhalation valve is disposed at the output end of the holding chamber and is moveable to an open position in response to an inhalation flow through the interior space. A vacuum generator, expandable volume and/or positive pressure may be used to draw medication from the dry powder inhaler into the holding chamber. Methods of using and assembling the system are also provided.