Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract: An improved apparatus for varying the pressure applied to a clutch system that can be used to couple a rotational input with a rotational output. Depending on the load and direction of torque in the clutch system, the improved apparatus will engage a spring with more force or less force to affect the amount of torque transferred by the clutch system and the force required by an operator to manually disengage the clutch system.

Abstract: An apparatus and system are disclosed for automatic centrifugal engagement of a pressure plate. The apparatus includes a center clutch coupled rotationally with a transmission input shaft, a clutch basket coupled rotationally with an engine output shaft, and a clutch pack disposed between the center clutch and the clutch basked. The clutch pack includes a plurality of drive plates rotationally coupled to the center clutch and a plurality of friction plates rotationally coupled with the clutch basket. The apparatus also includes a pressure plate assembly that is spring-loaded and disposed between the center clutch and the clutch basket. The pressure plate assembly comprises a pressure plate, a spring plate, and a spring disposed between the pressure plate and the spring plate. The system includes the apparatus and a manual override capable of use with cable actuated and hydraulic actuated clutch levers.

Abstract: An apparatus and system are disclosed for automatic centrifugal engagement of a pressure plate. The apparatus includes a clutch basket, a clutch pack capable of coupling the clutch basket with a center clutch, a pressure plate axially moveable toward the clutch pack, and a top plate coupled to a rotating hub. The rotating hub is configured to pass through an opening in the pressure plate. The apparatus also includes at least one centrifugal actuating member disposed between the pressure plate and the top plate, and at least one spring disposed between the rotating hub and the center clutch to bias the pressure plate relative to the top plate.

Abstract: A method of controlling access to playable content. The disclosed method includes receiving a request to access playable content having a plurality of associated access criteria, receiving a plurality of credentials, performing a matching process to compare the credentials to the access criteria, and allowing access to the playable content is permitted if the access criteria are met by a logical combination of the plurality of credentials.

Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.

Abstract: A method of controlling access to playable content, the method comprising the steps of

Abstract: In order to facilitate the management of content items intended to be hosted by one or more content server systems, each item has associated behavior data that specifies a desired commercial behavior of that item as a function of at least one variable. The commercial behavior specified by the behavior data concerns, for example, placement, promotion or pricing of the content item. When a commercial decision is required concerning an item, its relevant behavior data, together with a current value of the said at least one variable concerned, is used to make the decision. By giving the content items their own autonomous behavior, the content provider is freed from being continually asked to make decisions regarding commercialization of the items.

Abstract: Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.

Abstract: A method of providing content over the Internet to a third party, comprises the steps of: receiving a request for content from a purchaser, establishing payment for the requested content, and establishing an identifier to permit access to the requested content by a third party.

Abstract: A method and system is provided for billing for access to individual content items on a downloadable page. Each such item is only downloaded with, or for incorporation into, the rest of the page if selected for access by a user requesting the page. At the time of downloading the item, the server generates an item-dependent billing event.

Abstract: Disclosed is a Barbeque Turner with a plate, an armature and a handle. Food, which is engaged by the plate, is turned by the pull of a trigger which actuates gears within the handle which, in turn, rotate that armature and the plate which is attached thereto.

Abstract: A fixed body wide field-of-view conformal antenna array suitable for broadband precision direction finding on missile platforms. The array is configured as multiple sub-arrays of spiral antennas that cover particular regions within the desired field-of-view of the entire array. A lower cost, more reliable and more accurate direction finding solution for missile needs is provided, primarily by the elimination of conventional radomes and antenna gimbal structures. The array can be configured to include multi-mode sensors.

Abstract: A fixed body wide field-of-view conformal antenna array suitable for broadband precision direction finding on missile platforms. The array is configured as multiple sub-arrays of spiral antennas that cover particular regions within the desired field-of-view of the entire array. A lower cost, more reliable and more accurate direction finding solution for missile needs is provided, primarily by the elimination of conventional radomes and antenna gimbal structures. The array can be configured to include multi-mode sensors.

Abstract: A fixed body wide field-of-view conformal antenna array suitable for broadband precision direction finding on missile platforms. The array is configured as multiple sub-arrays of spiral antennas that cover particular regions within the desired field-of-view of the entire array. A lower cost, more reliable and more accurate direction finding solution for missile needs is provided, primarily by the elimination of conventional radomes and antenna gimbal structures. The array can be configured to include multi-mode sensors.