Patents by Inventor Sean C. Bendall
Sean C. Bendall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220186184Abstract: The present disclosure generally relates to compositions and methods useful for an adoptive cell therapy. Some embodiments of the disclosure relates to methods for producing a population of lymphocytes enriched in T stem cell memory cells (TSCM cells). Further provided are compositions containing a substantially pure population of TSCM cells that are therapeutically effective in treating various cancers, and kits containing such compositions. Methods for treating a subject having or suspected of having a cancer using the compositions and kits as disclosed herein are also provided.Type: ApplicationFiled: January 10, 2019Publication date: June 16, 2022Inventors: Zinaida Good, Garry P. Nolan, Sean C. Bendall, Evan Weber, Crystal Mackall
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Publication number: 20210310970Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: ApplicationFiled: October 6, 2020Publication date: October 7, 2021Inventors: GARRY P. NOLAN, Sean C. Bendall, Robert M. Angelo
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Patent number: 10832795Abstract: A method and apparatus for simultaneously determining multiple different biological molecule types in a sample include labeling each different biological molecule type in a biological sample with a unique combination of a plurality of labels. Each different biological molecule type is selected from a population of M different biological molecules types. The plurality of labels is selected from a population of L different labels; and, M is greater than L. Measurements are obtained of relative abundances of the L different labels in the sample. Relative abundance of up to M different biological molecule types in the sample are determined based on the measurements and a method of compressed sensing.Type: GrantFiled: March 22, 2017Date of Patent: November 10, 2020Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Karen Sachs, Mohammed N. AlQuraishi, Solomon Itani, Garry P. Nolan, Sean C. Bendall, Tyler J. Burns
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Publication number: 20190339250Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: ApplicationFiled: October 29, 2018Publication date: November 7, 2019Inventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
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Publication number: 20190162729Abstract: A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (SIMS) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set. In many embodiments, the data set contains the identity and abundance of the mass tag. A system for performing the method is also provided.Type: ApplicationFiled: May 25, 2018Publication date: May 30, 2019Inventors: Sean C. Bendall, Garry P. Nolan, Robert M. Angelo
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Patent number: 10114004Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: GrantFiled: August 16, 2017Date of Patent: October 30, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
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Patent number: 10041949Abstract: A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (SIMS) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set. In many embodiments, the data set contains the identity and abundance of the mass tag. A system for performing the method is also provided.Type: GrantFiled: September 11, 2014Date of Patent: August 7, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sean C. Bendall, Garry P. Nolan, Robert M. Angelo
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Publication number: 20180150596Abstract: A method and apparatus for simultaneously determining multiple different biological molecule types in a sample include labeling each different biological molecule type in a biological sample with a unique combination of a plurality of labels. Each different biological molecule type is selected from a population of M different biological molecules types. The plurality of labels is selected from a population of L different labels; and, M is greater than L. Measurements are obtained of relative abundances of the L different labels in the sample. Relative abundance of up to M different biological molecule types in the sample are determined based on the measurements and a method of compressed sensing.Type: ApplicationFiled: March 22, 2017Publication date: May 31, 2018Inventors: Karen Sachs, Mohammed N. AlQuraishi, Solomon Itani, Garry P. Nolan, Sean C. Bendall, Tyler J. Burns
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Publication number: 20170343529Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: ApplicationFiled: August 16, 2017Publication date: November 30, 2017Inventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
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Patent number: 9766224Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: GrantFiled: March 11, 2016Date of Patent: September 19, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
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Publication number: 20170178882Abstract: A mass spectrometer system for elemental analysis of a planar sample is provided. In some embodiments, the mass spectrometer system comprises: a primary ion source capable of irradiating a segment on planar sample with a beam of primary ions that is less than 1 mm in diameter, c) an orthogonal ion mass-to-charge ratio analyzer positioned downstream of sample interface, the analyzer being configured to separate secondary elemental atomic ions according to their mass-to-charge ratio by time of flight; d) an ion detector for detecting the secondary elemental atomic ions and producing mass spectra measurements; and e) a synchronizer, wherein the system is configured so that so that the beam of primary ions scans across the planar sample in two dimensions and the synchronizer associates the mass spectra measurements with positions on the planar sample.Type: ApplicationFiled: March 30, 2015Publication date: June 22, 2017Inventors: Sean C. Bendall, Robert M. Angelo, Garry P. Nolan
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Publication number: 20160282325Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.Type: ApplicationFiled: March 11, 2016Publication date: September 29, 2016Inventors: GARRY P. NOLAN, Sean C. Bendall, Robert M. Angelo
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Patent number: 9312111Abstract: A mass spectrometer system having: a primary ion source capable of irradiating a segment on a planar sample with a beam of primary ions, an orthogonal ion mass-to-charge ratio, the analyzer being configured to separate secondary elemental atomic ions according to their mass-to-charge ratio by time of flight; an ion detector for detecting secondary elemental atomic ions and producing mass spectra measurements; and a synchronizer. In the system, the beam of primary ions scans across the planar sample in two dimensions and the synchronizer associates the mass spectra measurements with positions on the planar sample.Type: GrantFiled: March 30, 2015Date of Patent: April 12, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sean C. Bendall, Robert M. Angelo, Garry P. Nolan
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Publication number: 20150287578Abstract: A mass spectrometer system for elemental analysis of a planar sample is provided. In some embodiments, the mass spectrometer system comprises: a primary ion source capable of irradiating a segment on planar sample with a beam of primary ions that is less than 1 mm in diameter, c) an orthogonal ion mass-to-charge ratio analyzer positioned downstream of sample interface, the analyzer being configured to separate secondary elemental atomic ions according to their mass-to-charge ratio by time of flight; d) an ion detector for detecting the secondary elemental atomic ions and producing mass spectra measurements; and e) a synchronizer, wherein the system is configured so that so that the beam of primary ions scans across the planar sample in two dimensions and the synchronizer associates the mass spectra measurements with positions on the planar sample.Type: ApplicationFiled: March 30, 2015Publication date: October 8, 2015Inventors: Sean C. Bendall, Robert M. Angelo, Garry P. Nolan
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Publication number: 20150080233Abstract: A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (SIMS) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set. In many embodiments, the data set contains the identity and abundance of the mass tag. A system for performing the method is also provided.Type: ApplicationFiled: September 11, 2014Publication date: March 19, 2015Inventors: Sean C. Bendall, Garry P. Nolan, Robert M. Angelo
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Publication number: 20140221241Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.Type: ApplicationFiled: February 5, 2014Publication date: August 7, 2014Inventors: Garry P. Nolan, Erin F. Simonds, Sean C. Bendall, Bernd Bodenmiller
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Publication number: 20140106976Abstract: A method and apparatus for simultaneously determining multiple different biological molecule types in a sample include labeling each different biological molecule type in a biological sample with a unique combination of a plurality of labels. Each different biological molecule type is selected from a population of M different biological molecules types. The plurality of labels is selected from a population of L different labels; and, M is greater than L. Measurements are obtained of relative abundances of the L different labels in the sample. Relative abundance of up to M different biological molecule types in the sample are determined based on the measurements and a method of compressed sensing.Type: ApplicationFiled: March 15, 2013Publication date: April 17, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Karen Sachs, Mohammed N. AlQuraishi, Solomon Itani, Garry P. Nolan, Sean C. Bendall, Tyler J. Burns
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Patent number: 8679858Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.Type: GrantFiled: January 11, 2012Date of Patent: March 25, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Garry P. Nolan, Erin F. Simonds, Sean C. Bendall
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Publication number: 20120178183Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.Type: ApplicationFiled: January 11, 2012Publication date: July 12, 2012Inventors: Garry P. Nolan, Erin F. Simonds, Sean C. Bendall
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Publication number: 20120077714Abstract: Certain embodiments provide a method of sample analysis that comprises: a) labeling a particle using a specific binding reagent that is cleavably linked to an elemental tag; b) flowing the labeled particle through a flow cell of a mass cytometer; c) cleaving the elemental tag from the labeled particle; d) performing elemental analysis of the cleaved elemental tag without destroying the particle, to produce data; e) matching data for the particle with the particle; and f) collecting the particle. Also provided is a specific binding reagent that is cleavably linked to an elemental tag, and a mass cytometer adapted to perform the method.Type: ApplicationFiled: September 19, 2011Publication date: March 29, 2012Inventors: Garry P. Nolan, Sean C. Bendall, Peter O. Krutzik