Abstract: In various embodiments, implants including reservoirs, such as intraocular lenses, feature flexible membranes and valves integrated therewith, the valves having apertures that are normally closed.

Abstract: Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made based on the flow “tail” that occurs in a piston- or plunger-type pump as relaxation of the plunger material continues to push fluid out of the drug reservoir; this residual flow eventually ceases after the plunger returns to its natural state.

Abstract: In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.

Abstract: In various embodiments, ocular treatment systems, intraocular lenses, and treatment methods are utilized for the treatment or prevention of posterior capsule opacification of the eye by, for example, targeting portions of the posterior lens capsule for ablation while minimizing damage to implanted intraocular lenses.

Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.

Abstract: In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.

Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.

Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source.

Abstract: Mechanical and/or adhesive coupling features are added to an intraocular lens during fabrication or thereafter, and provide beneficial mechanical coupling to the lens capsule. The coupling features may pass through or otherwise engage complementary coupling apertures in the crystalline lens capsule.

Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: An imaging method includes providing a handpiece having a probe tip insertable into human or animal tissue disposed at an end thereof, and, an optical coherence tomography (OCT) probe connected to the handpiece such that a functionality of the OCT probe is provided at the probe tip. The probe tip is disposed adjacent to or into human or animal tissue. Imaging of the tissue, measuring at least one of a feature size or a quantifiable characteristic of a structure in the tissue for biometry analysis, and/or performing a diagnostic procedure on the tissue or a device implanted in the tissue is performed with the OCT probe.

Abstract: The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.

Abstract: A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane.

Abstract: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.

Abstract: A spiral-coil antenna conforming to a non-planar contour is deployed, in various embodiments, in an implantable device for controllably ejecting fluid into an anatomic region. The antenna facilitates wireless communications with the implantable device and external charging thereof. In one implementation, the device has a non-planar contour and the spiral coil defines a non-planar surface conforming to the non-planar contour.

Abstract: An implantable device has an outer shell that includes an aperture through the housing of the device and, spanning the aperture, a membrane structure permeable to gas but not to liquid. In this way, excess gas may be vented from the device. The membrane and aperture are designed to discourage or even prevent tissue ingrowth.