Abstract: Methods and systems for frame rate scalability are described. Support is provided for input and output video sequences with variable frame rate and variable shutter angle across scenes, or for input video sequences with fixed input frame rate and input shutter angle, but allowing a decoder to generate a video output at a different output frame rate and shutter angle than the corresponding input values. Techniques allowing a decoder to decode more computationally-efficiently a specific backward compatible target frame rate and shutter angle among those allowed are also presented.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating including collagen, glycerin and a hemostatic agent. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: Implementations relate to determining whether and/or how to implement a user request to prevent a particular search result from being provided in response to a search query. Some of those implementations grant or deny the request based on processing of the particular search result, the search query, and/or account information for a user submitting the user request. For example, some implementations process such information utilizing a classifier in determining whether to automatically deny the request, automatically approve the request, or to provide the request for manual review. Some additional or alternative implementations at least selectively automatically expand (or suggest for automatic expansion) an approval of a request to search result(s) and/or to one or more search queries that are not specified in the request.

Abstract: Technique for determining a data recovery duration involve determining a plurality of phases of data recovery. Such techniques further involve determining, based on a metadata metric set of a phase in the plurality of phases, a recovery duration of the phase, the recovery duration of the phase representing a duration required for recovery of the phase. Such techniques further involve determining the data recovery duration based on the recovery duration of the phase. Accordingly, a data recovery duration can be accurately predicted, and a user can know in advance how long data unavailability will last, which helps the user make a decision to schedule the data recovery in an appropriate time period, thereby being more effective and efficient for the user.

Abstract: Provided herein are viral vectors comprising a transgene encoding a compact effector protein and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Due to the small nature of the effector protein, the viral vector has ample room for additional genome editing cargo, such as a guide nucleic acid and a donor nucleic acid. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.

Abstract: Provided herein are substituted imidazo[1,2-a]pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-mediated disease.

Abstract: Neural Normalized MinSum (N-NMS) decoding for improving frame error rate (FER) performance on linear block codes over conventional normalized MinSum (NMS). Dynamic multiplicative weights are assigned to each check-to-variable message in each iteration to efficiently provide training parameters of N-NMS that support N-NMS for longer block lengths. Embodiment are described for neural two-dimensional normalized MinSum (N-2D-NMS) decoders requiring fewer training parameters. The N-2D-NMS approaches for example use the same weight for edges with the same check and/or variable node degree. Simulation results indicate that that this LDPC decoding performs similarly to previous techniques while substantially reducing the amount of training necessary.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A method of forming an implant includes positioning a first mesh component of the implant within a second mesh component of the implant to form an implant assembly. The implant assembly is manipulated to join the first mesh component with the second mesh component.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second polymer includes an alginate. The second coating has a hemostatic agent dispersed in the second polymer such that the second polymer releases the hemostatic agent as the second polymer degrades. The hemostatic agent is selected from epinephrine, tranexamic acid, chitosan and oxidized regenerated cellulose. In some embodiments, systems and methods are disclosed.

Abstract: A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second coating has ellagic acid dispersed in the second polymer such that the second polymer releases the ellagic acid as the second polymer degrades. In some embodiments, systems and methods are disclosed.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating includes a polymer, collagen, glycerin and a hemostatic agent. The polymer is selected from the group of polyhydroxybutyrate, polyglycerol sebacate and adducts of polyglycerol sebacate. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating including collagen, glycerin and a hemostatic agent. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

Abstract: A package for a surgical implant includes a body having a side wall including opposite top and bottom ends. The body includes a bottom wall coupled to the bottom end. The body includes a flange extending outwardly from the top end. Inner surfaces of the walls define a cavity. The top end defines an opening that is in communication with the cavity. An insert extends from the bottom wall such that the insert is positioned in the cavity. A lid is configured to be coupled to the flange such that the lid covers the opening. Devices, kits and systems are disclosed.

Abstract: A surgical device configured to surround an implantable medical device that includes a collagen membrane and a coating embedded in the membrane The coating including at least one active pharmaceutical ingredient.

Abstract: A cable assembly having a connector and a cable having a fiber connector, wherein the connector contains a circuit for converting electrical signals to optical signals for transmitting video or high data rate data, and the connector has an interface to connect with the fiber connector of the cable, so that the cable and the connector can be separated for making each of the connector and the cable as a standalone component.

Abstract: A surgical instrument includes a body extending along a longitudinal axis between opposite proximal and distal end surfaces. The distal end surface includes a first cavity and a second cavity. The first cavity includes a first light bulb disposed therein. The second cavity includes a second light bulb disposed therein. A shaft includes opposite proximal and distal ends. The proximal end is coupled to the body. A blade is coupled to the distal end. The first light bulb is an ultraviolet (UV) light bulb and the second light bulb is configured to emit visible light. Systems and methods of use are disclosed.

Abstract: Provided herein are substituted imidazo[1,2-a]pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a Janus kinase-mediated disease.

Abstract: A cable assembly includes a cable and a connector, wherein the connector of the cable assembly includes laser diodes for transmitting optical signals to optical fiber wires of the cable for transferring data received from an external device and a light-emitting diode (LED) for emitting a visible light to a plastic fiber wire of the cable so that a user can use the visible light for different purposes. In addition, the connector of the cable assembly is capable of conforming to a standard HDMI connector or integrated with an earphone.