Abstract: Provided herein are nanocarriers for delivery of immunosuppressive agents. In some embodiments, provided herein are nanocarriers comprising a core comprising a poly(ethylene glycol)-block-poly(propylene sulfide) copolymer and least one therapeutic agent. In some embodiments, the nanocarriers may further comprise a targeting ligand displayed on a surface of the nanocarrier. The at least one therapeutic agent may be an anti-inflammatory agent. The disclosed nanocarriers may be incorporated into pharmaceutical compositions for use in methods of treating an inflammatory condition or preventing transplantation rejection in a subject.

Abstract: A graphical user interface accessible to a user and suitable for receiving a user-supplied movement direction or selection input through a directional controller to manage focus, including: a plurality of objects configured in a hierarchical structure; a first focus transfer element configured to transfer the focus from the currently focused object when the user supplied movement direction is received from the directional controller; and a second focus transfer element configured to transfer the focus from the currently focused object when the selection input is received from the directional controller.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.

Abstract: A graphical user interface accessible to a user and suitable for receiving a user-supplied movement direction or selection input through a directional controller to manage focus, including: a plurality of objects configured in a hierarchical structure; a first focus transfer element configured to transfer the focus from the currently focused object when the user supplied movement direction is received from the directional controller; and a second focus transfer element configured to transfer the focus from the currently focused object when the selection input is received from the directional controller.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: A method for managing focus in a graphical user interface using a directional controller that allows a directional or selection input. The method comprising: determining whether the input is directional or selection; determining whether there is a sibling object of a currently focused object in a given direction of the input if the input is directional; transferring the focus to the sibling object if there is a sibling object in the given direction; transferring the focus to an ancestor object of the currently focused object if there is no sibling object in the given direction; determining whether the currently focused object is a group; transferring the focus to a descendant object of the currently focused object if the currently focused object is a group and the input is selection; and selecting the currently focused object if the currently focused object is not a group and the input is selection.

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

Abstract: Provided herein are nanocarriers for delivery of immunosuppressive agents. In some embodiments, provided herein are nanocarriers comprising a core comprising a poly(ethylene glycol)-block-poly(propylene sulfide) copolymer and least one therapeutic agent. In some embodiments, the nanocarriers may further comprise a targeting ligand displayed on a surface of the nanocarrier. The at least one therapeutic agent may be an anti-inflammatory agent. The disclosed nanocarriers may be incorporated into pharmaceutical compositions for use in methods of treating an inflammatory condition or preventing transplantation rejection in a subject.

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: The method and apparatus determine a specific position of a user-selectable region at a particular point in time within a sequence of display frames. The method and apparatus first interpolate between a first matrix representing the user-selectable region at a first point in time and a second matrix representing the user-selectable region at a second point in time. In one embodiment, the matrix generated by this interpolation is then applied to a region definition for the user-selectable region to determine the specific area occupied by the region at the particular point in time. According to one embodiment, the first matrix and the second matrix are both stored within the same sample of a container track. This sample corresponds to one or more frames of the sequence of display frames. In an alternate embodiment, the first matrix and the second matrix are stored in two separate samples of the container track.

Abstract: A method and apparatus determine a specific position of a user-selectable region at a particular point in time within a sequence of display frames. The method and apparatus first interpolate between a first matrix representing the user-selectable region at a first point in time and a second matrix representing the user-selectable region at a second point in time. In one embodiment, the matrix generated by this interpolation is then applied to a region definition for the user-selectable region to determine the specific area occupied by the region at the particular point in time. According to one embodiment, the first matrix and the second matrix are both stored within the same sample of a container track. This sample corresponds to one or more frames of the sequence of display frames. In an alternate embodiment, the first matrix and the second matrix are stored in two separate samples of the container track.

Abstract: The method and apparatus determine a specific position of a user-selectable region at a particular point in time within a sequence of display frames. The method and apparatus first interpolate between a first matrix representing the user-selectable region at a first point in time and a second matrix representing the user-selectable region at a second point in time. In one embodiment, the matrix generated by this interpolation is then applied to a region definition for the user-selectable region to determine the specific area occupied by the region at the particular point in time. According to one embodiment, the first matrix and the second matrix are both stored within the same sample of a container track. This sample corresponds to one or more frames of the sequence of display frames. In an alternate embodiment, the first matrix and the second matrix are stored in two separate samples of the container track.