Patents by Inventor Sean D. Taverna

Sean D. Taverna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7851175
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: December 14, 2010
    Assignees: The Board of Trustees of the University of Arkansas, The Rockefeller University
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Patent number: 7670795
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: March 2, 2010
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Publication number: 20100041085
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enyzmatically acetylated or deacetylated.
    Type: Application
    Filed: October 13, 2009
    Publication date: February 18, 2010
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Publication number: 20090061469
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Application
    Filed: June 12, 2007
    Publication date: March 5, 2009
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna