Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: A test fixture for testing aerosol provision devices includes a housing, a plurality of testing modules disposed at the housing where each of the testing modules includes a cavity configured to receive a portion of an aerosol provision device, and processing circuitry operably coupled to the testing modules. Each of the testing modules is configured to interface with an assembly of a respective one of the aerosol provision devices to transition the assembly between an initial state and a transitioned state during a functional test controlled by the processing circuitry. The processing circuitry is configured to conduct the functional test of at least two of the testing modules simultaneously.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and a lock assembly configured to perform either one or both of preventing recharging the power source and preventing the application of the power from the power source to the device electronics in a locked state, and to enable recharging the power source and the application of power from the power source to the device electronics in an unlocked state. The lock assembly may be configured to detect a wake event while the lock assembly is in the locked state, wake the lock assembly in response to the wake event, perform an authentication process, and, in response to completing the authentication process, transition the lock assembly between the locked state and the unlocked state.

Abstract: An electronic nicotine delivery systems (“ENDS”) device may include aerosol delivery devices such as smoking articles that produce aerosol. The device may include a cartridge for the aerosol production. The cartridge is assigned a unique identifier that is approved for a user or that user's device such that the cartridge and/or the device only operate when approved. The unique identifiers help with user identification, tracking, and age verification.

Abstract: The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and a lock assembly configured to perform either one or both of preventing recharging the power source and preventing the application of the power from the power source to the device electronics in a locked state, and to enable recharging the power source and the application of power from the power source to the device electronics in an unlocked state. The lock assembly may be configured to detect a wake event while the lock assembly is in the locked state, wake the lock assembly in response to the wake event, perform an authentication process, and, in response to completing the authentication process, transition the lock assembly between the locked state and the unlocked state.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: A method of preventing unauthorized use of an aerosol provision device may include receiving a wireless signal including an unlock code for unlocking the aerosol provision device, processing the wireless signal to determine host device characterization information or environmental context information, tuning processing circuitry to process the unlock code based on the host device characterization information or environmental context information, and transitioning the aerosol provision device from a locked state to an unlocked state responsive to processing the unlock code.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and an authentication module. The authentication module may include a separate chip or circuit board relative to the device electronics. The authentication module may be inserted into the aerosol delivery device between the power source and the device electronics to control provision of the power to the device electronics for generation of the aerosol or between the power source and a charge port of the aerosol delivery device to control charging of the power source.

Abstract: A charger for an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices provides functionality for authentication, including age verification. Such devices may be restricted based on age or other factors that require some form of authentication, verification, and/or identification to satisfy the restriction. The accessory or charger may provide or connect with a verification system for confirming an age of a user. If the authentication or verification is not satisfied, the charger or accessory will not charge the device, rendering it unusable.

Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: A test fixture for testing aerosol provision devices may include a housing, a plurality of testing modules disposed at the housing where each of the testing modules includes a cavity configured to receive a portion of an aerosol provision device, and processing circuitry operably coupled to the testing modules. Each of the testing modules may be configured to interface with an assembly of a respective one of the aerosol provision devices to transition the assembly between an initial state and a transitioned state during a functional test controlled by the processing circuitry. The processing circuitry may be configured to conduct the functional test of at least two of the testing modules simultaneously.

Abstract: A test fixture for testing aerosol provision devices may include one or more testing modules including a cavity configured to receive a portion of an aerosol provision device, processing circuitry operably coupled to the one or more testing modules, and an impedance-based interface module configured to detect insertion of the aerosol provision device into the test fixture and automatically transition the aerosol provision device to a locked state. The processing circuitry may be configured to provide a transition signal to the aerosol provision device to transition the aerosol provision device between the locked state and an unlocked state during a functional test controlled by the processing circuitry.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and an authentication module. The authentication module may include a separate chip or circuit board relative to the device electronics. The authentication module may be inserted into the aerosol delivery device between the power source and the device electronics to control provision of the power to the device electronics for generation of the aerosol or between the power source and a charge port of the aerosol delivery device to control charging of the power source.

Abstract: A charger for an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices provides functionality for authentication, including age verification. Such devices may be restricted based on age or other factors that require some form of authentication, verification, and/or identification to satisfy the restriction. The accessory or charger may provide or connect with a verification system for confirming an age of a user. If the authentication or verification is not satisfied, the charger or accessory will not charge the device, rendering it unusable.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.