Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the aerosol delivery device comprises a control device that includes an outer housing defining a cartridge receiving chamber, and further includes a power source and a control component, and a cartridge that includes a mouthpiece, a tank, a heating assembly, and a bottom cap. The mouthpiece defines an exit portal in an end thereof, and the tank is configured to contain a liquid composition therein. The cartridge is configured to be removably coupled with the receiving chamber of the control device, and the heating assembly defines a vaporization chamber and is configured to heat the liquid composition to generate an aerosol. The heating assembly comprises a substantially planar heating member and a liquid transport element, wherein the heating member is installed in a bowed orientation.

Abstract: An aerosol provision device is provided that includes aerosol-generating material. The aerosol provision device includes an aerosol generator powered by the power source to energize the aerosol-generating material to generate an aerosol for delivery to a user. The aerosol provision device includes circuitry configured to control power to the aerosol generator to energize the aerosol-generating material. The circuitry includes processing circuitry configured to determine a temperature of the aerosol generator, determine a temperature function of the aerosol generator, and determine if the aerosol-generating material has reached an end of life (EOL) at which there is less than a threshold amount of the aerosol-generating material, based on the temperature and/or temperature function of the aerosol generator. The processing circuitry may further be configured to disable the aerosol generator when the aerosol-generating material has reached the EOL.

Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: An aerosol provision device is provided that includes a power source and circuitry, and the circuitry includes a sensor and processing circuitry. The sensor is configured to produce measurements of air pressure through at least a portion of the aerosol provision device. The processing circuitry is configured to determine a device baseline rate of change of air pressure from the measurements, and detect a puff event, the puff event defined by a predetermined difference between a rate of change of air pressure from the measurements and the device baseline rate of change of air pressure. An aerosol generator is powered by the power source under control of the circuitry to energize an aerosol-generating material to generate an aerosol for delivery to a user, when the pressure caused by the airflow indicates use of the aerosol provision device.

Abstract: A method of bending a conduit is disclosed. An engagement member is displaced via contact with the conduit and engages a switch. A signal is sent to a microprocessor indicative of a characteristic of the conduit to be bent, in response to engagement of the switch. The microprocessor provides a motor control signal to the motor to control a rotation of the shoe, wherein rotation of the shoe bends the conduit.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: The present disclosure provides an aerosol delivery device comprising a control device that is connectable with a cartridge and that can include one or more additional elements for improving one or both of visible indications of use to a user and resistance to infiltration of liquid into the control device. More particularly, the control device may include a light guide configured for transmitting to a window from a light source that is off-set from the window and a controller configured to direct a varying level of light from the light source. The control device may include one or more elements that are configured to limit infiltration of liquids into the control device and thus may be consider to be water-resistant or water-proof.

Abstract: The present disclosure provides an aerosol delivery device comprising a control device that is connectable with a cartridge and that can include one or more additional elements for improving one or both of visible indications of use to a user and resistance to infiltration of liquid into the control device. More particularly, the control device may include a light guide configured for transmitting to a window from a light source that is off-set from the window and a controller configured to direct a varying level of light from the light source. The control device may include one or more elements that are configured to limit infiltration of liquids into the control device and thus may be consider to be water-resistant or water-proof.

Abstract: There is provided an aerosol provision system for generating an aerosol from a liquid aerosol-generating material, the aerosol provision system including a reservoir of liquid aerosol generating material, an aerosol generator configured to aerosolize liquid aerosol generating material from the reservoir, a wicking element configured to supply liquid aerosol generating material from the reservoir to the aerosol generator, and an adjustment mechanism configured to adjust a dimension of the wicking element to modify a rate of supply of liquid aerosol generating material through the wicking element to modify a characteristic of an aerosol generated by the aerosol generator during use.

Abstract: There is provided an aerosol provision system for generating an aerosol from an aerosol-generating material during a session of use, the aerosol provision system including an aerosol-generating material, at least one heater configured to aerosolise the aerosol-generating material, and a plurality of substances disposed within the aerosol provision system and arranged to be released at different times during the session of use. A first substance of the plurality of substances is encapsulated by a first shell, and a second substance of the plurality of substances is encapsulated by a second shell.

Abstract: Disclosed herein are reagents for use in antibody profiling platforms, such as biopanning and Digital Serology, specifically for eptiope motifs directed to SARS-CoV-2. Also disclosed herein are kits, method of manufacturing, and methods of using the same.

Abstract: A holder for an aerosol delivery device, the holder including: an aerosol delivery device receiving region configured to receive at least a portion of an aerosol delivery device; a controller configured to establish a data communication link with an aerosol delivery device; wherein the controller comprises a memory element configured to store user profile information for an aerosol delivery device; and wherein the controller is configured to selectively transmit user profile information from the memory element to the aerosol delivery device over the data communication link, and / or to receive user profile information from the aerosol delivery device over the data communication link and store the user profile information on the memory element.

Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the aerosol delivery device comprises a control device that includes an outer housing defining a cartridge receiving chamber, and further includes a power source and a control component, and a cartridge that includes a mouthpiece, a tank, a heating assembly, and a bottom cap. The mouthpiece defines an exit portal in an end thereof, and the tank is configured to contain a liquid composition therein. The cartridge is configured to be removably coupled with the receiving chamber of the control device, and the heating assembly defines a vaporization chamber and is configured to heat the liquid composition to generate an aerosol. The heating assembly comprises a substantially planar heating member and a liquid transport element, wherein the heating member is installed in a bowed orientation.

Abstract: An aerosol delivery system for generating aerosol from a consumable part, the aerosol delivery system including: a sensor; and a controller, wherein the controller is configured to: establish a target operating characteristic for the aerosol delivery system; establish, using the sensor, identifying information associated with a consumable part coupled to the aerosol delivery system; identify the consumable part is one of a plurality of different types of consumable part, based on the identifying information; and control at least one aspect of the operation of the aerosol delivery system on the basis of the target operating characteristic of the aerosol delivery system and the identifying information associated with at least one consumable part coupled to the aerosol delivery system.

Abstract: A charger for an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices provides functionality for authentication, including age verification. Such devices may be restricted based on age or other factors that require some form of authentication, verification, and/or identification to satisfy the restriction. The accessory or charger may provide or connect with a verification system for confirming an age of a user. If the authentication or verification is not satisfied, the charger or accessory will not charge the device, rendering it unusable.

Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: A machine forms a whip from a length of cable. The machine includes a clamping assembly, a notching assembly, and a cutting assembly. The clamping assembly includes a pad which can be move into and out of a cable travel space. The notching assembly includes a notching saw which cuts an outer jacket of the cable in a direction substantially parallel to the longitudinal axis. Movement of the pad also causes movement of the notching saw to move into the cable travel space or into a raised position. The cutting assembly includes a cutting tool which transversely cuts the conductors of the cable.