Abstract: The application relates to a composition comprising a stably integrating delivery vector, a modified mammalian thymidylate kinase (tmpk) that increases phosphorylation of a prodrug relative to phosphorylation of the prodrug by wild-type human tmpk, and a detection cassette fused to the tmpk. The application also relates to use of these compositions in methods of treatment of diseases, such as graft versus host disease and cancer.

Abstract: Embodiments of the present disclosure relate to accessories for containers and containers integrated with the accessories that provide a user increased precision in applying the contents of a container to a surface. The accessories or containers may include an arm that serves as a guide so that a user can apply the contents alongside an edge of the surface. Furthermore, the accessories or containers may provide the user with a high-degree of control over the distance from the edge that the contents are applied alongside.

Abstract: A door assistant includes a generally wedge-shaped portion and a handle. The wedge-shaped portion includes a surface defined between a first lower end and a second higher end. The handle includes a generally vertically extending portion and a grasping portion. The handle operates between a first orientation in which the grasping portion is aligned with the wedge shaped portion, and a second orientation in which the grasping portion is aligned with a surface of a door when the door assistant is in use. The handle places the wedge-shaped portion in a desired position relative to a lower edge of a door by a user. The door assistant further includes a foot pad extending rearwardly from the wedge-shaped portion, and has a surface sloping downward from the second higher end to the first lower end.

Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.

Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.

Abstract: A door assistant apparatus for retaining an opened door in a desired position, comprising a wedge-shaped portion, a foot pad portion and a vertically extending handle portion. The handle portion includes a grasping portion rotatably mounted to a vertical element of the handle portion. The grasping portion is operable between a first position substantially aligned with the wedge-shaped portion and the foot pad portion, and a second position wherein the grasping portion is substantially aligned with a surface of a door to which the door assistant has been applied.

Abstract: A bag toss game target assembly and system that can be enjoyed by two or more people. The bag toss target assembly comprises a plurality of panels, at least one of which defines a plurality of apertures. The bag toss game system comprises a target assembly and a plurality of shots. The shots comprise a cover and a fill material. A method for playing a bag toss game comprises at least two players tossing shots at a target assembly and awarding points based on the resting location of the shots. The game may be won by the player winning the most number of points or rounds in the game.

Abstract: An engagement index reflects a user's level of engagement with a digital resource. Actions of the user, such as the amount of time spent on a page, the number of pages accessed, the amount of time spent in a session, and the number and type of annotations made may be used as factors in the determination of the engagement index. Data values corresponding to one or more of the factors are received and are validated to eliminate any extreme values and to make the values comparable with one another. Different validation methods may be used for different factors. Once the data values are validated, weighting coefficients are applied to the validated values. The system then determines the engagement index by summing the weighted values. Once calculated, the engagement index may be aggregated with other engagement indexes or compared to engagement indexes for other users.

Abstract: An engagement index reflects a user's level of engagement with a digital resource. Actions of the user, such as the amount of time spent on a page, the number of pages accessed, the amount of time spent in a session, and the number and type of annotations made may be used as factors in the determination of the engagement index. Data values corresponding to one or more of the factors are received and are validated to eliminate any extreme values and to make the values comparable with one another. Different validation methods may be used for different factors. Once the data values are validated, weighting coefficients are applied to the validated values. The system then determines the engagement index by summing the weighted values. Once calculated, the engagement index may be aggregated with other engagement indexes or compared to engagement indexes for other users.

Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.

Abstract: A door assistant apparatus for retaining an opened door in a desired position, comprising a wedge-shaped portion, a foot pad portion and a vertically extending handle portion. The handle portion includes a grasping portion rotatably mounted to a vertical element of the handle portion. The grasping portion is operable between a first position substantially aligned with the wedge-shaped portion and the foot pad portion, and a second position wherein the grasping portion is substantially aligned with a surface of a door to which the door assistant has been applied.

Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.

Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.