Abstract: Molecular beacons and developmental methods related thereto. Methods include obtaining a nucleotide sequence for an aptamer that binds to a target analyte. The aptamer comprises a binding domain nucleotide sequence, a first domain nucleotide sequence, and a displacement domain nucleotide sequence complementary to the first domain nucleotide sequence. A molecular beacon is developed based on the nucleotide sequence of the aptamer by preserving the binding domain nucleotide sequence and truncating or extending one or both of the first domain nucleotide sequence or the displacement domain nucleotide sequence. The resultant molecular beacon is developed such that the molecular beacon comprises a Gibbs free energy value that is greater than the Gibbs free energy value of the aptamer.

Abstract: Systems and methods for operating a tag system. The methods comprising: emitting a wireless signal from an antenna of the tag with a first signal characteristic when the tag is proximate to an active antenna modulation marker; changing an impedance of a sensor from a first impedance value to a second impedance value when the active antenna modulation marker is exposed to a stimulus; and emitting a wireless signal from the antenna of the tag with a second signal characteristic when the tag is proximate to the active antenna modulation marker and the sensor has the second impedance value.

Abstract: Affinity sensors may exhibit advantaged regeneration behavior when pH is changed in proximity to a sensing element. Such affinity sensors may comprise at least one sensing element comprising a recognition moiety that interacts with an analyte by reversibly forming an analyte complex, and a solid-state pH-modulating element in proximity to the at least one sensing element, wherein formation of the analyte complex is pH-dependent and the at least one sensing element provides a signal that changes when the analyte complex reversibly forms, and a change in magnitude of the signal is correlatable to an amount of analyte interacted with the at least one sensing element.

Abstract: Systems and methods for operating a tag system. The methods comprising: emitting a wireless signal from an antenna of the tag with a first signal characteristic when the tag is proximate to an active antenna modulation marker; changing an impedance of a sensor from a first impedance value to a second impedance value when the active antenna modulation marker is exposed to a stimulus; and emitting a wireless signal from the antenna of the tag with a second signal characteristic when the tag is proximate to the active antenna modulation marker and the sensor has the second impedance value.

Abstract: One embodiment provides a chemical reactor, which can comprise a substrate for facilitating chemical reactions occurring at triple-phase boundaries. One possible substrate may further comprise a set of dynamically controllable sites and/or pixels upon which control signals may affect a desired formation of gas bubbles over an active catalytic (or other desired) solid surface in a liquid flow—wherein a chemical reaction in two or more phase boundaries may occur. In yet another embodiment, a control algorithm may send control signals to controllable sites/pixels to maximize the operation of the reactor according to a desired metric (e.g., product formation) that may input a set of sensor data to affect its control.