Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: A cleaning tool is provided and includes a cleaning head moveable between a plurality of configurations. The cleaning head may include a main panel, a handle coupled to the main panel via a universal joint, a first side panel pivotally coupled to a first edge of the main panel, and a second side panel pivotally coupled to a second edge of the main panel opposite the first edge. The cleaning tool may also include two biasing members for biasing the first and second panels toward a flat position and at least one ramp member engageable with a surface to pivot at least one of the first and second side panels upward out of its flat position toward an upward pivoted position. The cleaning tool may further include an actuator for pivoting one or more of the side panels between flat and upward pivoted positions, and a selectively deployable scrubber.

Abstract: A scrub brush for cleaning a variety of surfaces. The scrub brush includes an arcuate main body, a handle connected to the top surface of the main body, and a plurality of bristles extending from a bottom surface of the main body. The body is curved such that it forms a recess below the handle to protect a user's fingers and/or knuckles during use. The bristles extend from the main body such that they define a curved cleaning surface that has the same general shape and contour as the bottom surface of the main body. Two types of bristles, each having a different stiffness, may be included to provide two different types of cleaning.

Abstract: A cleaning tool including a removable and reversible cleaning member and separate angled scrubbing bristles. The cleaning member can have different cleaning surfaces for both heavy and light scrubbing, or the same cleaning material on both surfaces for longer use of the cleaning member. The cleaning tool may also include connectors for coupling a cleaning cloth or sheet to the cleaning tool.

Abstract: A toilet brush includes a handle and head, which has both bristles and wiping members. The bristles provide a scrubbing surface and define under-rim extensions, the wiping members provide a wiping or scraping surfaces in addition to the scrubbing surface for removal of more stubborn debris.

Abstract: A cleaning tool is provided and includes a cleaning head moveable between a plurality of configurations. The cleaning head may include a main panel, a handle coupled to the main panel via a universal joint, a first side panel pivotally coupled to a first edge of the main panel, and a second side panel pivotally coupled to a second edge of the main panel opposite the first edge. The cleaning tool may also include two biasing members for biasing the first and second panels toward a flat position and at least one ramp member engageable with a surface to pivot at least one of the first and second side panels upward out of its flat position toward an upward pivoted position. The cleaning tool may further include an actuator for pivoting one or more of the side panels between flat and upward pivoted positions, and a selectively deployable scrubber.

Abstract: A bucket and a method of using a bucket are provided. In one example, the bucket may include a side wall and bottom wall together defining a cavity for receiving contents such as solids and liquids. The bucket also includes a pour handle coupled to the side wall, a pour spout defined in the side wall opposite the pour handle, a carrying handle rotatably connected to the side wall, a portion of the side wall being translucent to allow a user to view the contents or a shadow of the contents of the bucket, and a plurality of volume indicators on the side wall for assisting a user with determining the quantity of the contents within the bucket. In some constructions, the plurality of volume indicators may be positioned on the translucent portion of the side wall.