Abstract: Techniques of automated quality control for digital pathology whole slide images are presented. The techniques include obtaining a thumbnail image derived from a whole slide image of a pathology slide; determining whether the whole slide image includes an artifact in a first class of artifacts by providing the thumbnail image to an electronic neural network trained to detect artifacts in the first class of artifacts by analyzing a plurality of labeled training thumbnail images; generating a tissue mask representing tissue depicted in the thumbnail image; determining whether the whole slide image includes an artifact in a second class of artifacts by performing a comparison using the tissue mask; and providing an indication of whether the whole slide image includes an artifact in the first class of artifacts or an artifact in the second class of artifacts.