Patents by Inventor Sean Johnston

Sean Johnston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems, Methods and Apparatus for Application of Targeted Temperature Management Therapy Utilizing Concentric In/Out Cable
    Publication number: 20240082050
    Abstract: Disclosed herein are systems and methods for providing targeted temperature management (TTM) therapy to a patient. For example, TTM systems include a connection system for coupling a fluid deliver line to a thermal contact pad. The connection system is configured to provide indication to the user that the fluid deliver line is completely connected to thermal contact pad. In addition, the connection system also includes a controller for activating a connection lock and for sharing signals with a TTM system module. The fluid deliver line includes a pair of conduits arranged concentrically and the thermal pad includes a TTM fluid filter disposed within a fluid containing layer.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 14, 2024
    Inventors: Gabriel A. Johnston, Jesse Smith, Mengjia Yi, Niharika Pathare, Sean E. Walker
  • POLYMORPHIC FORMS OF (R)-OXYBUTYNIN HYDROCHLORIDE
    Publication number: 20230286900
    Abstract: Polymorphic forms of (R)-oxybutynin HCl, including three crystalline forms, are prepared and characterized. Uses of the various polymorphic forms of (R)-oxybutynin HCl for Obstructive Sleep Apnea (OSA) treatment are also disclosed.
    Type: Application
    Filed: May 4, 2021
    Publication date: September 14, 2023
    Inventors: Dennis MOLNAR, Sean JOHNSTON
  • PROCESS FOR MAKING SARECYCLINE HYDROCHLORIDE
    Publication number: 20210017123
    Abstract: The described invention relates to sarecycline, related compounds, intermediates and salts thereof and processes for preparing the same.
    Type: Application
    Filed: April 5, 2019
    Publication date: January 21, 2021
    Inventors: Giovanni PALOMBI, Eugenio CASTELLI, Giuseppe MOTTA, Meinrad BRENNER, Ruiliang LU, Shaozhi HUANG, William Paul ARMSTRONG, Gajanan JOSHI, Farzaneh SEYEDI, Sean JOHNSTON
  • Methods for synthesizing and purifying aminoalkyl tetracycline compounds
    Patent number: 9434680
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: September 6, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sean Johnston, Tadeusz Warchol
  • Oral and injectable formulations of tetracycline compounds
    Patent number: 9314475
    Abstract: Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention pertains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formulations may be used, for example, to treat infections.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: April 19, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventor: Sean Johnston
  • Methods of increasing oral bioavailability of tetracyclines
    Patent number: 9078811
    Abstract: Methods for increasing the oral bioavailability of tetracycline compounds are described.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: July 14, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Adel Bakhtyari, Sean Johnston, Masha Pukshansky
  • METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS
    Publication number: 20100113401
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sean Johnston, Tadeusz Warchol
  • Oral and Injectable Formulations of Tetracycline Compounds
    Publication number: 20100056638
    Abstract: Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention pertains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formulations may be used, for example, to treat infections.
    Type: Application
    Filed: March 30, 2009
    Publication date: March 4, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventor: Sean Johnston
  • Minocycline Compounds and Methods of Use Thereof
    Publication number: 20090253660
    Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
    Type: Application
    Filed: March 5, 2009
    Publication date: October 8, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventor: Sean Johnston
  • Methods for Synthesizing and Purifying Aminoalkyl Tetracycline Compounds
    Publication number: 20080287401
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: April 28, 2008
    Publication date: November 20, 2008
    Inventors: Sean Johnston, Tadeusz Warchol
  • Methods of increasing oral bioavailability of tetracyclines
    Publication number: 20080070873
    Abstract: Methods for increasing the oral bioavailability of tetracycline compounds are described.
    Type: Application
    Filed: January 24, 2007
    Publication date: March 20, 2008
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael Alekshun, Adel Bakhtyari, Sean Johnston, Masha Pukshansky