Abstract: A method for quantifying amounts of per- and poly-fluoroalkyl substances (PFAS) may use a PFAS detection system comprising a working electrode and one or more processors. The working electrode may have a polymer layer disposed on its surface that comprises a plurality of affinity sites for detecting a plurality of PFAS molecules. Each of the plurality affinity sites may have been created using a template PFAS. The method may comprise detecting, at the working electrode, a plurality PFAS molecules that have bonded to one or more of the plurality of affinity sites; and determining, by the one or more processors and based on the detected plurality of PFAS molecules that are bonded to the one or more affinity sites, a concentration of PFAS in an environment.

Abstract: Implementations relate to determining whether and/or how to implement a user request to prevent a particular search result from being provided in response to a search query. Some of those implementations grant or deny the request based on processing of the particular search result, the search query, and/or account information for a user submitting the user request. For example, some implementations process such information utilizing a classifier in determining whether to automatically deny the request, automatically approve the request, or to provide the request for manual review. Some additional or alternative implementations at least selectively automatically expand (or suggest for automatic expansion) an approval of a request to search result(s) and/or to one or more search queries that are not specified in the request.

Abstract: The thermally activated building panel (1) includes a metal plate (2) having a room-facing surface (3) and a building-facing surface (4). A heat-exchanger tube (5) for conveying a cooling or heating medium is in conductive thermal contact with the building-facing surface (4) of the metal plate (2). A textile (9) is arranged on the room-facing surface (3) of the metal plate (2) and has a first surface (10) generally contacting the metal plate (2) and a second surface (11) generally visible from said room. The textile (9) is tensioned between opposed edges (12) of the metal plate (2). The first surface (10) of the textile (9) is metallized by deposition of metal particles on the textile (9).

Abstract: Unicondylar tibia implant devices having a bone-facing, distal side that can be detailed with cement fixation features and may include any of or a plurality of grooves, pegs, fins, rails, cavities, and/or coating whereby the geometry of the implant device improves implant-to-cement or cement-to-bone fixation characteristics exceeding that of a traditional flat surface. The implant device may also include a proximal side facing away from the bone-facing, distal side and having a geometry that provides either articulation with (cartilage and meniscal substituting) or receipt of a secondary device coupleable to the implant device on the distal side of the secondary device that features an away-from-bone facing articulating feature. Additionally, the geometry of the implant device in anterior-posterior and medial-lateral directions, among other directions, provides a variety of improvements relative to currently available devices.

Abstract: Unicondylar tibia implant devices having a bone-facing, distal side that can be detailed with cement fixation features and may include any of or a plurality of grooves, pegs, fins, rails, cavities, and/or coating whereby the geometry of the implant device improves implant-to-cement or cement-to-bone fixation characteristics exceeding that of a traditional flat surface. The implant device may also include a proximal side facing away from the bone-facing, distal side and having a geometry that provides either articulation with (cartilage and meniscal substituting) or receipt of a secondary device coupleable to the implant device on the distal side of the secondary device that features an away-from-bone facing articulating feature. Additionally, the geometry of the implant device in anterior-posterior and medial-lateral directions, among other directions, provides a variety of improvements relative to currently available devices.

Abstract: Unicondylar tibia implant devices having a bone-facing, distal side that can be detailed with cement fixation features and may include any of or a plurality of grooves, pegs, fins, rails, cavities, and/or coating whereby the geometry of the implant device improves implant-to-cement or cement-to-bone fixation characteristics exceeding that of a traditional flat surface. The implant device may also include a proximal side facing away from the bone-facing, distal side and having a geometry that provides either articulation with (cartilage and meniscal substituting) or receipt of a secondary device coupleable to the implant device on the distal side of the secondary device that features an away-from-bone facing articulating feature. Additionally, the geometry of the implant device in anterior-posterior and medial-lateral directions, among other directions, provides a variety of improvements relative to currently available devices.

Abstract: The thermally activated building panel (1) includes a metal plate (2) having a room-facing surface (3) and a building-facing surface (4). A heat-exchanger tube (5) for conveying a cooling or heating medium is in conductive thermal contact with the building-facing surface (4) of the metal plate (2). A textile (9) is arranged on the room-facing surface (3) of the metal plate (2) and has a first surface (10) generally contacting the metal plate (2) and a second surface (11) generally visible from said room. The textile (9) is tensioned between opposed edges (12) of the metal plate (2). The first surface (10) of the textile (9) is metallized by deposition of metal particles on the textile (9).

Abstract: A patient specific guide block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: Unicondylar tibia implant devices having a bone-facing, distal side that can be detailed with cement fixation features and may include any of or a plurality of grooves, pegs, fins, rails, cavities, and/or coating whereby the geometry of the implant device improves implant-to-cement or cement-to-bone fixation characteristics exceeding that of a traditional flat surface. The implant device may also include a proximal side facing away from the bone-facing, distal side and having a geometry that provides either articulation with (cartilage and meniscal substituting) or receipt of a secondary device coupleable to the implant device on the distal side of the secondary device that features an away-from-bone facing articulating feature. Additionally, the geometry of the implant device in anterior-posterior and medial-lateral directions, among other directions, provides a variety of improvements relative to currently available devices.

Abstract: A patient specific guide block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: A low profile patient specific cutting block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: An implant having components comprising an oxidized zirconium bearing surface adapted to decrease pain, lower friction, and minimize wear when coupled with natural femoral articular cartilage. The implant components also provide for reduced backside wear effects in fixed and mobile implants. The implant components further provide for more ideal wear coupling between components in mobile bearing implants.

Abstract: A low profile patient specific cutting block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: A low profile patient specific cutting block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: A method positions a profile of a prosthetic component on the three-dimensional model of a limb. Patient-specific anatomical data of the limb is gathered. First and second anatomical landmarks are identified to determine a first spatial relationship. A third anatomical landmark is identified to determine a second spatial relationship with respect to the first spatial relationship. The profile of the prosthetic component is positioned in all but one degree of freedom. A fourth anatomical landmark is identified to position the profile of the prosthetic component in the one remaining degree of freedom.

Abstract: A low profile patient specific cutting block for a knee includes a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface that is generally a negative of the portion of the bone that the respective bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone, and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth relative to the bone interfacing portions.

Abstract: A low profile patient specific cutting block for a knee comprises a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface generally a negative of the portion of the bone the bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of bone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth from the bone interfacing portions.

Abstract: Disclosed herein is a newly discovered problem and solution for engineering S. cerevisiae to ferment xylose to make ethanol utilizing xylose isomerase to convert xylose to xylulose for entry, via xylulokinase, into the pentose phosphate pathway. The problem is that when grown on a media containing xylose xylitol tends to accumulate in the cell despite the absence of xylose reductase activity in S. cerevisiae. Xylitol inhibits the activity of xylose isomerases. One solution described is to simultaneously express an exogenous xylitol dehydrogenase along with the exogenous xylose isomerase while optionally also overexpressing xylulokinase in the absence of expression of a xylose reductase. Another solution is a xylose isomerase from Bacteroides fragilis which is less inhibited by xylitol than other xylose isomerases, exemplified by E. coli xylose isomerase.

Abstract: An implant having components comprising an oxidized zirconium bearing surface adapted to decrease pain, lower friction, and minimize wear when coupled with natural femoral articular cartilage. The implant components also provide for reduced backside wear effects in fixed and mobile implants. The implant components further provide for more ideal wear coupling between components in mobile bearing implants.

Abstract: A device and method for resecting a distal portion of a femur comprises a distal cutting guide [98], a valgus guide [102], and a variable collet [10]. The distal cutting guide [98] is configured to overlie an anterior portion of the femur and comprises a slot for guiding a cutting tool across a distal portion of the femur. The valgus guide [102] is configured to connect to the distal cutting guide [98]. The valgus guide [102] is configured to align the slot of the distal cutting guide [98] at the proper varus/valgus angle. The variable collet [10] is configured to attach to an intramedullary rod and the valgus guide [102]. The variable collet [10] comprises a port [30] for receiving the intramedullary rod. The port [30] is angularly adjustable with respect to the valgus guide [102] such that adjusting the port [30] adjusts the varus/valgus angle of the distal cutting guide [98].