Abstract: Mesoporous silica nanoparticles (MSNs) that may be useful as ultrasound contrast agents for detecting and treating bladder cancer are described herein. The MSNs include a lanthanide, a fluorophore, and an agent detectable by ultrasound.

Abstract: Mesoporous silica nanoparticles (MSNs) that may be useful as ultrasound contrast agents for detecting and treating bladder cancer are described herein. The MSNs include a lanthanide, a fluorophore, and an agent detectable by ultrasound.

Abstract: The invention provides methods, devices and compositions that employ EuGd203 nanoparticles, e.g., for imaging. The invention provides for devices having lanthanide doped gadolinium nanoparticles and uses for lanthanide doped, for instance, europium doped, gadolinium (e.g., Eu—Gd203) nanoparticles in sequential imaging. For example, Eu—Gd203 nanoparticles are employed as multimodal/sequential contrast agents for combinations of MRI, CT, ultrasound, and photoacoustics or other imaging modalities such as optical imaging. The invention provides a method comprising administering, for instance, injecting, a composition comprising lanthanide doped gadolinium nanoparticles into a subject, e.g.

Abstract: The invention provides particles useful for sequential imaging or for diagnostics or therapeutics. Disclosed is a method to image diagnostic or therapeutic cells in a mammal, comprising: introducing to a mammal a composition comprising mammalian cells comprising mesoporous silica nanoparticles (MSNs) comprising a lanthanide, a fluorophore and an agent detectable by ultrasound; applying ultrasound and/or a magnetic field to the mammal and recording ultrasound and/or magnetic resonance images that include the MSNs; and detecting the presence, location or amount of the MSNs in the mammal.