Abstract: A system is provided for guiding an interventional instrument (150) to an internal target in a subject. The system includes a guide device (100) configured to rest on an outer surface of the subject and a shape sensing device (140). The guide device includes a holder (120) configured to receive the interventional instrument (150) and to provide an entry trajectory of the interventional instrument (150) for guiding the interventional instrument (150) to the target; and a fastener (130) attached to a portion of the guide device (100). The shape sensing device (140) provides shape sensing data indicating a shape of at least a portion of the shape sensing device (140) secured to the guide device (100) by the fastener (130). The shape sensing data enables determination of a position and orientation of the guide device (100) on the outer surface of the subject.

Abstract: A computer-implemented method of predicting a success metric, achieved by performing a treatment procedure on a thrombus, is provided. The method includes: receiving angiographic image data, including one or more angiographic images comprising the thrombus; inputting the angiographic image data into a model, comprising a neural network, configured to output a prediction related to the treatment procedure; and calculating the success metric based on the output of the model.

Abstract: A training data modification system (TDM) for machine learning and related methods. The system comprises a data modifier (DM) configured to perform a modification operation to modify medical training X-ray imagery of a patient. The modification operation causes image structures in the modified medical training imagery. The image structure is representative of a property of i) a medical procedure, ii) an image acquisition operation by an X-ray-based medical imaging apparatus (IA), iii) an anatomy of the patient.