Patents by Inventor Sean Leo Willis
Sean Leo Willis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12049525Abstract: A polymer having a backbone comprising a polyhydroxylated polymer cross linked by a C3 to C8 diacid.Type: GrantFiled: June 26, 2019Date of Patent: July 30, 2024Assignee: Boston Scientific Medical Device LimitedInventors: Yiqing Tang, Andrew Lennard Lewis, Jonathan Vince, Hugh Britton, Koorosh Ashrafi, Damien Guegan, Sean Leo Willis
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Patent number: 11957755Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.Type: GrantFiled: May 25, 2021Date of Patent: April 16, 2024Assignee: Boston Scientific Medical Device LimitedInventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20230355833Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1 —(C?O)—O— C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
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Patent number: 11744916Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.Type: GrantFiled: July 20, 2020Date of Patent: September 5, 2023Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
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Publication number: 20230158148Abstract: In various embodiments, the present disclosure pertains to compositions for medical use. In some embodiments, the compositions comprise an aqueous solution of a block copolymer that comprises one or more poly(N-isopropylamino acrylamide) blocks and one or more poly(2-(di-(C1-5)alkylamino) (C1-5)alkyl methacrylate) blocks. In some embodiments, the compositions are in liquid form at 25° C. Other embodiments pertain to methods that comprise delivering such compositions to a patient.Type: ApplicationFiled: November 22, 2022Publication date: May 25, 2023Applicant: Boston Scientific Scimed Inc.Inventors: Yiqing Tang, Nicolas Van Luc Busatto, Francesco Cuda, Sean Leo Willis
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Publication number: 20210275674Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.Type: ApplicationFiled: May 25, 2021Publication date: September 9, 2021Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Patent number: 11040104Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.Type: GrantFiled: January 3, 2020Date of Patent: June 22, 2021Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20210115171Abstract: A polymer having a backbone comprising a polyhydroxylated polymer cross linked by a C3 to C8 diacid.Type: ApplicationFiled: June 26, 2019Publication date: April 22, 2021Inventors: Yiqing Tang, Andrew Lennard Lewis, Jonathan Vince, Hugh Britton, Koorosh Ashrafi, Damien Guegen, Sean Leo Willis
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Patent number: 10925979Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: January 3, 2020Date of Patent: February 23, 2021Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20210015963Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.Type: ApplicationFiled: July 20, 2020Publication date: January 21, 2021Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
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Publication number: 20200254099Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.Type: ApplicationFiled: January 3, 2020Publication date: August 13, 2020Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Patent number: 10568967Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.Type: GrantFiled: January 9, 2019Date of Patent: February 25, 2020Assignee: Biocompatibles UK Ltd.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Patent number: 10556022Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: September 5, 2018Date of Patent: February 11, 2020Assignee: Biocompatibles UK Ltd.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Patent number: 10350295Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.Type: GrantFiled: September 5, 2014Date of Patent: July 16, 2019Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20190142946Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.Type: ApplicationFiled: January 9, 2019Publication date: May 16, 2019Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20160228556Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.Type: ApplicationFiled: September 5, 2014Publication date: August 11, 2016Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Publication number: 20160193367Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: ApplicationFiled: September 5, 2014Publication date: July 7, 2016Applicant: Biocompatibles UK LTDInventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
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Patent number: 7300990Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2?-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.Type: GrantFiled: January 3, 2005Date of Patent: November 27, 2007Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Sean Leo Willis, Steven Peter Armes, Emma Janice Lobb, Yinghua Ma
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Patent number: 7064174Abstract: A silicon containing adduct having the formula (I) wherein X is an electron withdrawing group selected from the group consisting of carbonyl and sulphone groups, sulphonium and phosphonium salts; R is selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, di-alkylaminoalkyl, N-aryl-N-alky-laminoalkyl, hydroxyalkoxy, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkynyloxy, aralkoxy, alkoxyaryloxy, alkoxyalkoxy, oligoalkoxyalkoxy, di-alkylaminoalkoxy, N-aryl-N-alkylamino-alkoxy, acyloxy, acyloxyalkyl, N-diacyl-iminoalkyl groups, organosilane, organosiloxane, hydroxyaryl, hydroxyalkenyl, hydroxyalkynyl and hydroxy groups and any of the above groups substituted with one or more hydroxyl or xzwitterionic group Z, or R—X— is a nitrile group; R3 and R4 are individually selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl,Type: GrantFiled: February 7, 2001Date of Patent: June 20, 2006Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Anthony Claude Marie Collias, Richard Paul Redman, Jane Louise Court, Sean Leo Willis
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Patent number: 6893595Abstract: A method in which a mould is coated with a reactive polymer, a liquid curable composition is filled into the mould and cured under conditions such that the reactive polymer becomes covalently bonded to the cured bulk mould material at the interface. The reactive polymer has zwitterionic groups to confer improved biocompatibility on the moulded product. The reactive group on the reactive polymer is conveniently an ethylenically unsaturated group. The curable composition is suitably a radical polymerisable ethylenically unsaturated monomer mixture or a platinum-curable liquid silicone composition.Type: GrantFiled: July 19, 1999Date of Patent: May 17, 2005Assignee: Biocompatibles UK LimitedInventors: Andrew Victor Graham Muir, Paula Frances Lennon, Sean Leo Willis, Richard Paul Redman, Anthony Claude Marie Collias