Patents by Inventor Sean Leo Willis

Sean Leo Willis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12049525
    Abstract: A polymer having a backbone comprising a polyhydroxylated polymer cross linked by a C3 to C8 diacid.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: July 30, 2024
    Assignee: Boston Scientific Medical Device Limited
    Inventors: Yiqing Tang, Andrew Lennard Lewis, Jonathan Vince, Hugh Britton, Koorosh Ashrafi, Damien Guegan, Sean Leo Willis
  • Patent number: 11957755
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: April 16, 2024
    Assignee: Boston Scientific Medical Device Limited
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20230355833
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1 —(C?O)—O— C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
  • Patent number: 11744916
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: September 5, 2023
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
  • Publication number: 20230158148
    Abstract: In various embodiments, the present disclosure pertains to compositions for medical use. In some embodiments, the compositions comprise an aqueous solution of a block copolymer that comprises one or more poly(N-isopropylamino acrylamide) blocks and one or more poly(2-(di-(C1-5)alkylamino) (C1-5)alkyl methacrylate) blocks. In some embodiments, the compositions are in liquid form at 25° C. Other embodiments pertain to methods that comprise delivering such compositions to a patient.
    Type: Application
    Filed: November 22, 2022
    Publication date: May 25, 2023
    Applicant: Boston Scientific Scimed Inc.
    Inventors: Yiqing Tang, Nicolas Van Luc Busatto, Francesco Cuda, Sean Leo Willis
  • Publication number: 20210275674
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Application
    Filed: May 25, 2021
    Publication date: September 9, 2021
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 11040104
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: June 22, 2021
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20210115171
    Abstract: A polymer having a backbone comprising a polyhydroxylated polymer cross linked by a C3 to C8 diacid.
    Type: Application
    Filed: June 26, 2019
    Publication date: April 22, 2021
    Inventors: Yiqing Tang, Andrew Lennard Lewis, Jonathan Vince, Hugh Britton, Koorosh Ashrafi, Damien Guegen, Sean Leo Willis
  • Patent number: 10925979
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: February 23, 2021
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20210015963
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 21, 2021
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
  • Publication number: 20200254099
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Application
    Filed: January 3, 2020
    Publication date: August 13, 2020
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10568967
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: February 25, 2020
    Assignee: Biocompatibles UK Ltd.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10556022
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: February 11, 2020
    Assignee: Biocompatibles UK Ltd.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10350295
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: July 16, 2019
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20190142946
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20160228556
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 11, 2016
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20160193367
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: Biocompatibles UK LTD
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 7300990
    Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2?-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: November 27, 2007
    Assignee: Biocompatibles UK Limited
    Inventors: Andrew Lennard Lewis, Sean Leo Willis, Steven Peter Armes, Emma Janice Lobb, Yinghua Ma
  • Patent number: 7064174
    Abstract: A silicon containing adduct having the formula (I) wherein X is an electron withdrawing group selected from the group consisting of carbonyl and sulphone groups, sulphonium and phosphonium salts; R is selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, di-alkylaminoalkyl, N-aryl-N-alky-laminoalkyl, hydroxyalkoxy, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkynyloxy, aralkoxy, alkoxyaryloxy, alkoxyalkoxy, oligoalkoxyalkoxy, di-alkylaminoalkoxy, N-aryl-N-alkylamino-alkoxy, acyloxy, acyloxyalkyl, N-diacyl-iminoalkyl groups, organosilane, organosiloxane, hydroxyaryl, hydroxyalkenyl, hydroxyalkynyl and hydroxy groups and any of the above groups substituted with one or more hydroxyl or xzwitterionic group Z, or R—X— is a nitrile group; R3 and R4 are individually selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl,
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: June 20, 2006
    Assignee: Biocompatibles UK Limited
    Inventors: Andrew Lennard Lewis, Anthony Claude Marie Collias, Richard Paul Redman, Jane Louise Court, Sean Leo Willis
  • Patent number: 6893595
    Abstract: A method in which a mould is coated with a reactive polymer, a liquid curable composition is filled into the mould and cured under conditions such that the reactive polymer becomes covalently bonded to the cured bulk mould material at the interface. The reactive polymer has zwitterionic groups to confer improved biocompatibility on the moulded product. The reactive group on the reactive polymer is conveniently an ethylenically unsaturated group. The curable composition is suitably a radical polymerisable ethylenically unsaturated monomer mixture or a platinum-curable liquid silicone composition.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: May 17, 2005
    Assignee: Biocompatibles UK Limited
    Inventors: Andrew Victor Graham Muir, Paula Frances Lennon, Sean Leo Willis, Richard Paul Redman, Anthony Claude Marie Collias