Patents by Inventor Sean M. Tonzi

Sean M. Tonzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
    Patent number: 6942990
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-?-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: September 13, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • D-hydantoinase from Ochrobactrum anthropi
    Patent number: 6800465
    Abstract: The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: October 5, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Politino, Sean M. Tonzi, Guna Romancik, John J. Usher, David A. Lowe
  • Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203
    Publication number: 20030143715
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Application
    Filed: January 17, 2003
    Publication date: July 31, 2003
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
    Patent number: 6528300
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • D-hydantoinase from Ochrobactrum anthropi
    Publication number: 20030013102
    Abstract: The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
    Type: Application
    Filed: April 3, 2002
    Publication date: January 16, 2003
    Inventors: Michael Politino, Sean M. Tonzi, Guna Romancik, John J. Usher, David A. Lowe
  • Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203
    Publication number: 20020160500
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Application
    Filed: September 21, 2001
    Publication date: October 31, 2002
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Cephalosporin esterase gene from Rhodosporidium toruloides
    Patent number: 5869309
    Abstract: The instant invention provides nucleic acid molecules encoding cephalosporin esterase from Rhodosporidium toruloides. In addition, the invention provides isolated cephalosporin esterase, expression vectors, host cells, and methods of producing cephalosporin esterase.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michael Politino, Sean M. Tonzi, John J. Usher, William V. Burnett, Guna Romancik
  • Penicillin V amidohydrolase gene from Fusarium oxysporum
    Patent number: 5516679
    Abstract: Nucleic acids coding for penicillin V amidohydrolase (PVA) from Fusarium oxysporum. Also, expression vectors, host cells and a method for production of PVA.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: May 14, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shu-Jen Chiang, William V. Burnett, Jr., Sean M. Tonzi