Abstract: Provided herein are formulations and methods of using a TLR-7 agonist for the treatment of hepatitis B virus infection.

Abstract: Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

Abstract: A system and method are provided for the management of electronic data representing emergency alerts. The system includes a server that receives data records representing an emergency event and computes a corresponding severity metric. If the severity metric exceeds a threshold, the server transmits a control signal from a server to a computing device. The control signal can cause the computing device to control an alarm system, vehicle navigation system, automated email system, user interface, or automated messaging system.

Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.

Abstract: A system and method are provided for the management of electronic data representing emergency alerts. The system includes a server that receives social media data records representing an emergency event and computes a corresponding severity metric. If the severity metric exceeds a threshold, the server transmits a control signal from a server to a computing device. The control signal can cause the computing device to control an alarm system, vehicle navigation system, automated email system, user interface, or automated messaging system.

Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.

Abstract: Provided herein are formulations and methods of using a TLR-7 agonist for the treatment of hepatitis B virus infection.

Abstract: A system and method are provided for the management of electronic data representing emergency alerts. The system includes a server that receives social media data records representing an emergency event and computes a corresponding severity metric. If the severity metric exceeds a threshold, the server transmits a control signal from a server to a computing device. The control signal can cause the computing device to control an alarm system, vehicle navigation system, automated email system, user interface, or automated messaging system.

Abstract: Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

Abstract: According to examples, an apparatus may include a processor that may divide content of a document to be indexed into sections. The apparatus may divide and arrange each section into a hierarchy based on linguistic, spatial, or other analysis. The apparatus may identify a context of each section that may provide an indication of the subject matter of the section. The apparatus may add the context to downstream sections in the hierarchy. The apparatus may generate an index entry for each section based on the content of the section and any added context from upstream sections. Thus, the index entry for a given section may be based on the context of the given section and context of upstream sections in the hierarchy. In this way, the index entries may account for not only the content of the given section, but also context from upstream sections.

Abstract: Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

Abstract: A method, system and program product for group policy backup management in a network having a plurality of domains including components and modules for steps of retrieving a list of group policy objects for a domain, generating a configuration initialization file including a domains section identifying a plurality of domains that are to be backed up and a setup section specifying a plurality of values that control the backup of each policy object in each domain, determining a digital signature for each policy object on a list of policies for the domain, comparing the digital signature for each policy object with a corresponding previous digital signature for each policy, determining if a current digital signature for each policy object matches the corresponding previous digital signature for a policy, and backing up a policy object having a current digital signature that does not match the corresponding previous digital signature.

Abstract: Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (“Compound 1”), dispersible tablets comprising Compound 1, processes of manufacturing such tablets, and methods for treating patients with the tablets. Compound 1 is useful for treating hematological disorders such as sickle cell disease, pulmonary disease such as idiopathic pulmonary fibrosis, and hypoxia and hypoxemia conditions.

Abstract: The present disclosure relates to novel crystalline salt forms of lamivudine, methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of viruses such as Human Immunodeficiency Virus (HIV) infection.

Abstract: According to an example, a computer may receive characteristics information of an object in a video stream captured by a first computing device, generate a signature based on the characteristics information, identify an augmented reality information associated with the signature, transmit the augmented reality information to the first computing device, receive, from a second computing device, a set of characteristics information of the object in an image captured by the second computing device, determine that the set of characteristics information from the second computing device has a second signature that matches the signature generated based on the characteristics information received form the first computing device, and transmit the identified augmented reality information to the second computing device.

Abstract: A method, system and program product for group policy backup management in a network having a plurality of domains including components and modules for steps of retrieving a list of group policy objects for a domain, generating a configuration initialization file including a domains section identifying a plurality of domains that are to be backed up and a setup section specifying a plurality of values that control the backup of each policy object in each domain, determining a digital signature for each policy object on a list of policies for the domain, comparing the digital signature for each policy object with a corresponding previous digital signature for each policy, determining if a current digital signature for each policy object matches the corresponding previous digital signature for a policy, and backing up a policy object having a current digital signature that does not match the corresponding previous digital signature.

Abstract: The systems and methods may allow mobile computing devices to identify real world trigger items and to cause augmented reality scenarios associated with a real world trigger item to be presented on a display of the mobile computing device. A lookup scheme may identify indexed feature points of known candidate trigger items stored in a database. A number of evaluations occur between the indexed feature points to the feature points found in the real world trigger item. A determination that the feature points of a candidate trigger item matches the feature points of the real world trigger item is made when a confidence threshold is met or exceeded based on at least the look up scheme, weighted factor evaluation, variable threshold evaluation and potentially a geometric consistency evaluation to declare a positive match.

Abstract: A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.

Abstract: The systems and methods may allow mobile computing devices to identify real world trigger items and to cause augmented reality scenarios associated with a real world trigger item to be presented on a display of the mobile computing device. A lookup scheme may identify indexed feature points of known candidate trigger items stored in a database. A number of evaluations occur between the indexed feature points to the feature points found in the real world trigger item. A determination that the feature points of a candidate trigger item matches the feature points of the real world trigger item is made when a confidence threshold is met or exceeded based on at least the look up scheme, weighted factor evaluation, variable threshold evaluation and potentially a geometric consistency evaluation to declare a positive match.

Abstract: The systems and methods allow users of mobile computing devices to generate augmented reality scenarios. Augmented reality content is paired with a real world trigger item to generate the augmented reality scenario. The augmented reality content is overlaid onto frames on a video when a trigger item is detected. Each mobile computing device may have an augmented reality application resident on the mobile computing device to allow a user to generate the augmented reality scenarios.