Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: A separated lift-thrust (SLT) aircraft includes a longitudinal-thrust engine and articulated electric rotors, at least some of which are variable-position rotors having variable orientations based on rotor position signals. Control circuitry independently controls thrust of the longitudinal-thrust engine and the thrust and orientation of each of the variable-position rotors, relative to the aircraft lifting surface and longitudinal thrust engine, to provide for commanded thrust-vectoring maneuvering of the aircraft during VTOL, fixed wing flight, and intermediate transitional states, including maintenance of a desired pose of the lifting surface independent of orientation of the rotor orientations when hovering the aircraft in windy conditions. A flight and navigation control system automates flight maneuvers and maintains desired aircraft pose and position relative to static or dynamic coordinates during station keeping, tracking, avoidance, or convergence maneuvers.

Abstract: An aircraft includes an airframe having a fixed-wing section and a plurality of articulated electric rotors, at least some of which are variable-position rotors having different operating configurations based on rotor position. A first operating configuration is a vertical-flight configuration in which the rotors generate primarily vertical thrust for vertical flight, and a second operating configuration is a horizontal-flight configuration in which the rotors generate primarily horizontal thrust for horizontal fixed-wing flight. Control circuitry independently controls rotor thrust and rotor orientation of the variable-position rotors to provide thrust-vectoring maneuvering. The fixed-wing section may employ removable wing panels so the aircraft can be deployed both in fixed-wing and rotorcraft configurations for different missions.

Abstract: The present invention relates to methods and compositions for the treatment of hemangioma, and particularly, but not exclusively, methods and compositions for the treatment of infantile hemangioma. In certain aspects, the methods comprise locally administering an ACE inhibitor or an ATIIR2 antagonist to a subject. In other aspects, the methods comprise systemically administering two or more of an ACE inhibitor, a beta-blocker and an ATIIR2 antagonist. The present invention also relates to compositions that are suitable for local administration and comprise: an ACEi and a beta-blocker; an ACEi and an ATIIR2 antagonist; a beta-blocker and an AT11R2 antagonist; or, an ACEi, a beta-blocker, and an AT11R2 antagonist.

Abstract: An aircraft employs articulated, variable-position electric rotors having different operating configurations and transitions therebetween, as well as variable-pitch airfoils or blades, for generating vectored thrust in the different configurations. Control circuitry generates rotor position signals and blade pitch signals to independently control rotor thrust, rotor orientation and rotor blade pitch of the variable-position rotors in a manner providing (i) the transitions among the operating configurations for corresponding flight modes of the aircraft, which may include both vertical takeoff and landing (VTOL) mode as well as a forward-flight mode, and (ii) commanded thrust-vectoring maneuvering of the aircraft in the different configurations, including tailoring blade pitch to optimize aspects of aircraft performance.

Abstract: A flight control arrangement for a hybrid aircraft includes a fixed-wing flight (F/W) control module and vertical takeoff/landing flight (VTOL) control module. The F/W control module is an integrated component having a respective network interface connected to an aircraft data network via which it provides fixed-wing control output to network-connected fixed-wing flight components including one or more horizontal-thrust components. The VTOL control module is also an integrated component having a respective network interface to the aircraft data network via which the VTOL control module (1) observes flight status as reflected in network messages originated by the fixed-wing flight control module, and (2) based on the observed flight status, generates VTOL control output to network-connected VTOL flight components including one or more vertical-thrust components, to control VTOL flight as well as transitions to and from fixed-wing flight.

Abstract: The present invention provides acoustically activated liposome compositions for use as drug delivery vehicles, and to methods for drug release and drug delivery for therapeutic applications including Parkinson's disease and epilepsy.

Abstract: The present invention provides acoustically activated liposome compositions for use as drug delivery vehicles, and to methods for drug release and drug delivery for therapeutic applications.

Abstract: A separated lift-thrust (SLT) aircraft includes a longitudinal-thrust engine and articulated electric rotors, at least some of which are variable-position rotors having variable orientations based on rotor position signals. Control circuitry independently controls thrust of the longitudinal-thrust engine and the thrust and orientation of each of the variable-position rotors, relative to the aircraft lifting surface and longitudinal thrust engine, to provide for commanded thrust-vectoring maneuvering of the aircraft during VTOL, fixed wing flight, and intermediate transitional states, including maintenance of a desired pose of the lifting surface independent of orientation of the rotor orientations when hovering the aircraft in windy conditions. A flight and navigation control system automates flight maneuvers and maintains desired aircraft pose and position relative to static or dynamic coordinates during station keeping, tracking, avoidance, or convergence maneuvers.

Abstract: An aircraft employs articulated, variable-position electric rotors having different operating configurations and transitions therebetween, as well as variable-pitch airfoils or blades, for generating vectored thrust in the different configurations. Control circuitry generates rotor position signals and blade pitch signals to independently control rotor thrust, rotor orientation and rotor blade pitch of the variable-position rotors in a manner providing (i) the transitions among the operating configurations for corresponding flight modes of the aircraft, which may include both vertical takeoff and landing (VTOL) mode as well as a forward-flight mode, and (ii) commanded thrust-vectoring maneuvering of the aircraft in the different configurations, including tailoring blade pitch to optimize aspects of aircraft performance.

Abstract: An articulated support includes a base and pitch-roll-yaw assembly having a pitch/roll subassembly and a yaw subassembly. The pitch/roll subassembly includes a central member configured for spring-loaded rotation about a pitch/roll axis, and the yaw subassembly has a U-shaped member configured (a) at end portions to engage under-wing connection lugs of an unmanned aircraft system (UAS) and (b) at a central portion to mate to the central member of the pitch/roll subassembly in a rotatable manner providing for rotation of the yaw subassembly about a yaw axis. The pitch/roll subassembly and yaw subassembly are further co-configured to define first and second fixed yaw positions in which a fuselage of the UAS is, respectively, parallel to and perpendicular to the pitch/roll axis, permitting roll motion and pitch motion of the UAS when mounted on the articulated support.

Abstract: An aircraft includes an airframe having a fixed-wing section and a plurality of articulated electric rotors, at least some of which are variable-position rotors having different operating configurations based on rotor position. A first operating configuration is a vertical-flight configuration in which the rotors generate primarily vertical thrust for vertical flight, and a second operating configuration is a horizontal-flight configuration in which the rotors generate primarily horizontal thrust for horizontal fixed-wing flight. Control circuitry independently controls rotor thrust and rotor orientation of the variable-position rotors to provide thrust-vectoring maneuvering. The fixed-wing section may employ removable wing panels so the aircraft can be deployed both in fixed-wing and rotorcraft configurations for different missions.

Abstract: The present invention provides acoustically activated liposome compositions for use as drug delivery vehicles, and to methods for drug release and drug delivery for therapeutic applications.

Abstract: An articulated support includes a base and pitch-roll-yaw assembly having a pitch/roll subassembly and a yaw subassembly. The pitch/roll subassembly includes a central member configured for spring-loaded rotation about a pitch/roll axis, and the yaw subassembly has a U-shaped member configured (a) at end portions to engage under-wing connection lugs of an unmanned aircraft system (UAS) and (b) at a central portion to mate to the central member of the pitch/roll subassembly in a rotatable manner providing for rotation of the yaw subassembly about a yaw axis. The pitch/roll subassembly and yaw subassembly are further co-configured to define first and second fixed yaw positions in which a fuselage of the UAS is, respectively, parallel to and perpendicular to the pitch/roll axis, permitting roll motion and pitch motion of the UAS when mounted on the articulated support.

Abstract: A power supply system for powering multiple external electrical devices. The power supply system has a housing with at least one outlet for receiving an electrical plug, a weight disposed inside the housing, and a gripping component disposed on an outer surface of a base of the housing. A power cord may be operatively connected to the outlet for supplying electrical power to the outlet. The weight provides stability to the housing and the gripping component secures the housing to an external surface when the power supply system is placed upon the external surface. The housing may further have at least one universal serial bus (USB) port and an On/Off switch for controlling input of electrical power.

Abstract: A process of producing ceramic-ceramic composites, including but not limited to nuclear fuels, and composites capable of exhibiting increased thermal conductivities. The process includes milling a first ceramic material to produce a powder of spheroidized particles of the first ceramic material, and then co-milling particles of a second ceramic material with the spheroidized particles of the first ceramic material to cause the particles of the second ceramic material to form a coating on the spheroidized particles of the first material. The spheroidized particles coated with the particles of the second ceramic material are then compacted and sintered to form the ceramic-ceramic composite, in which the second ceramic material forms a continuous phase completely surrounding the spheroidized particles of the first ceramic material.