Patents by Inventor Sean McCusker
Sean McCusker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11724265Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: GrantFiled: February 5, 2021Date of Patent: August 15, 2023Inventors: Kristopher Barbee, Rui Zheng, Sean McCusker
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Patent number: 11661619Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: GrantFiled: June 10, 2021Date of Patent: May 30, 2023Assignee: IsoPlexis CorporationInventors: Patrick Paczkowski, Sean Mackay, Sean McCusker
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Publication number: 20230138672Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: ApplicationFiled: December 23, 2022Publication date: May 4, 2023Inventors: Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
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Publication number: 20230052346Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: ApplicationFiled: October 26, 2022Publication date: February 16, 2023Inventors: Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
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Patent number: 11525783Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: GrantFiled: November 22, 2017Date of Patent: December 13, 2022Assignee: IsoPlexis CorporationInventors: Peter Tsiomplikas, Jerry Sedgewick, Jeffrey Whynall, Sean MacKay, Colin Ng, Patrick Paczkowski, Sean McCusker, Igor Nikonorov, Alaina Kaiser
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Publication number: 20220136030Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: ApplicationFiled: June 10, 2021Publication date: May 5, 2022Inventors: Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
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Patent number: 11066689Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: GrantFiled: January 27, 2020Date of Patent: July 20, 2021Assignee: IsoPlexis CorporationInventors: Patrick Paczkowski, Sean MacKay, Sean McCusker
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Publication number: 20210154683Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: ApplicationFiled: February 5, 2021Publication date: May 27, 2021Inventors: Kristopher BARBEE, Rui ZHENG, Sean MCCUSKER
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Publication number: 20210139949Abstract: A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions.Type: ApplicationFiled: September 21, 2020Publication date: May 13, 2021Inventors: Kristopher BARBEE, Ryan JONES, Sean MCCUSKER, Maximilian CARPINO, John LEAMON, Jonathan SCHULTZ
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Patent number: 10940490Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: GrantFiled: December 3, 2018Date of Patent: March 9, 2021Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Rui Zheng, Sean McCusker
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Patent number: 10781474Abstract: A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions.Type: GrantFiled: April 20, 2016Date of Patent: September 22, 2020Assignee: Life Technologies CorporationInventors: Kristopher Barbee, Ryan Jones, Sean McCusker, Maximilian Carpino, John Leamon, Jonathan Schultz
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Publication number: 20200239926Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: ApplicationFiled: January 27, 2020Publication date: July 30, 2020Inventors: Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
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Patent number: 10584366Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: GrantFiled: December 3, 2015Date of Patent: March 10, 2020Assignee: IsoPlexis CorporationInventors: Patrick Paczkowski, Sean MacKay, Sean McCusker
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Publication number: 20190376898Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: ApplicationFiled: November 22, 2017Publication date: December 12, 2019Applicant: IsoPlexis CorporationInventors: Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
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Publication number: 20190099765Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: ApplicationFiled: December 3, 2018Publication date: April 4, 2019Inventors: Kristopher BARBEE, Rui ZHENG, Sean MCCUSKER
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Patent number: 10144015Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: GrantFiled: November 7, 2014Date of Patent: December 4, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Rui Zheng, Sean McCusker
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Publication number: 20180105855Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: ApplicationFiled: December 3, 2015Publication date: April 19, 2018Inventors: Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
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Publication number: 20160230214Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.Type: ApplicationFiled: April 20, 2016Publication date: August 11, 2016Inventors: Kristopher BARBEE, Ryan JONES, Sean MCCUSKER, Maximilian CARPINO, John LEAMON, Jonathan SCHULTZ
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Publication number: 20160160169Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.Type: ApplicationFiled: December 3, 2015Publication date: June 9, 2016Inventors: Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
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Patent number: 9346063Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.Type: GrantFiled: March 14, 2013Date of Patent: May 24, 2016Assignee: Life Technologies CorporationInventors: Kristopher Barbee, Ryan Jones, Sean McCusker, Maximilian Carpino, John Leamon, Jonathan Schultz