Patents by Inventor Sean Michael White
Sean Michael White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11800990Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: GrantFiled: December 21, 2017Date of Patent: October 31, 2023Assignee: Covidien AGInventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 11759116Abstract: In some examples, a system includes processing circuitry configured to generate a laser speckle contrast signal based on a received signal indicative of detected light, wherein the detected light is scatted by tissue from a coherent light source. The processing circuitry may also determine, from the laser speckle contrast signal, a flow value and determine, from the laser speckle contrast signal, a waveform metric. Based on the flow value and the waveform metric, the processing circuitry may determine a blood flow metric for the tissue and output a representation of the blood flow metric.Type: GrantFiled: November 6, 2020Date of Patent: September 19, 2023Assignee: Covidien AGInventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 11709120Abstract: Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.Type: GrantFiled: April 4, 2017Date of Patent: July 25, 2023Assignee: Covidien AGInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Patent number: 11579004Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: GrantFiled: March 22, 2021Date of Patent: February 14, 2023Assignee: COVIDIEN AGInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20220142485Abstract: A point-of-care system with a diagnostic tool and a base station with a display and in communication with the diagnostic tool is described. Used in diagnosing health conditions for a tissue under analysis, the diagnostic tool includes a handle and a head portion. The head portion includes a speculum and optical spectroscopy (OS) data acquisition components positioned within the head portion. The OS data acquisition components are configure to (i) emit light toward the tissue under analysis, (ii) receive light reflected at least in part from the tissue under analysis based on the emitted light, and (iii) determine reflectance spectra associated with the received light. Either the diagnostic tool or a base station includes analytic components configured to (i) generate diagnostic metrics including characteristics of the reflectance spectra and (ii) compare these characteristics to data associated with characteristics of known reflectance spectra associated healthy and/or unhealthy tissue of patients.Type: ApplicationFiled: January 27, 2022Publication date: May 12, 2022Inventors: Samir G. Shreim, John Weidling, Mark Keating, Elliot L. Botvinick, Sean Michael White
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Publication number: 20210293595Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: ApplicationFiled: March 22, 2021Publication date: September 23, 2021Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20210196111Abstract: Systems and methods for use in detecting health condition of a physiological cavity or passageway are disclosed herein. In one example, the system may include one or more illuminators configured to illuminate a target area with light at discrete wavelengths. The system may additionally include detectors that are configured to receive a reflectance spectrum based on light emitted at discrete wavelengths from tissue and tissue constituents associated with the target area under analysis. Communicatively coupled to the one or more detectors, the processing unit is configured to analyse data associated with the reflectance spectra to produce one or more output values that identify the health condition.Type: ApplicationFiled: May 21, 2019Publication date: July 1, 2021Inventors: Samir G. Shreim, Elliot L. Botvinick, Hamid R. Djalilian, Sean Michael White, John Weidling
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Publication number: 20210177283Abstract: In some examples, a system includes processing circuitry configured to generate a laser speckle contrast signal based on a received signal indicative of detected light, wherein the detected light is scatted by tissue from a coherent light source. The processing circuitry may also determine, from the laser speckle contrast signal, a flow value and determine, from the laser speckle contrast signal, a waveform metric. Based on the flow value and the waveform metric, the processing circuitry may determine a blood flow metric for the tissue and output a representation of the blood flow metric.Type: ApplicationFiled: November 6, 2020Publication date: June 17, 2021Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 10955275Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: GrantFiled: April 18, 2017Date of Patent: March 23, 2021Assignee: Covidien LPInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20210022623Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes; a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: ApplicationFiled: October 12, 2020Publication date: January 28, 2021Inventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Patent number: 10813597Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: GrantFiled: April 14, 2017Date of Patent: October 27, 2020Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, COVIDIEN LPInventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Publication number: 20200158548Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: ApplicationFiled: April 18, 2017Publication date: May 21, 2020Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20190086316Abstract: Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.Type: ApplicationFiled: April 4, 2017Publication date: March 21, 2019Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20180296168Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: ApplicationFiled: April 14, 2017Publication date: October 18, 2018Inventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Publication number: 20180199829Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: ApplicationFiled: December 21, 2017Publication date: July 19, 2018Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 9848787Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: GrantFiled: February 7, 2013Date of Patent: December 26, 2017Assignee: Laser Associated Sciences, Inc.Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 9417690Abstract: Provided herein is a technique by which a user may interact with an apparatus configured to provide for display of an image, such as with augmented reality glasses. An example embodiment may provide a method including receiving an indication of a first motion event initiated on a first side of a device from a motion sensor, determining a first motion event pattern based on one or more directional components of the first motion event, distinguishing the first motion event from a motion event initiated on a second side of the device, correlating a first operation with the first motion event pattern, and causing the first operation to be performed. The first operation may include causing the opacity of an image presented on a substantially transparent display to be increased.Type: GrantFiled: May 1, 2014Date of Patent: August 16, 2016Assignee: Nokia Technologies OyInventors: Syed Reza Ali, Sean Michael White
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Publication number: 20140232645Abstract: Provided herein is a technique by which a user may interact with an apparatus configured to provide for display of an image, such as with augmented reality glasses. An example embodiment may provide a method including receiving an indication of a first motion event initiated on a first side of a device from a motion sensor, determining a first motion event pattern based on one or more directional components of the first motion event, distinguishing the first motion event from a motion event initiated on a second side of the device, correlating a first operation with the first motion event pattern, and causing the first operation to be performed. The first operation may include causing the opacity of an image presented on a substantially transparent display to be increased.Type: ApplicationFiled: May 1, 2014Publication date: August 21, 2014Applicant: Nokia CorporationInventors: Syed Reza Ali, Sean Michael White
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Patent number: 8749573Abstract: Provided herein is a technique by which a user may interact with an apparatus configured to provide for display of an image, such as with augmented reality glasses. An example embodiment may provide a method including receiving an indication of a first motion event initiated on a first side of a device from a motion sensor, determining a first motion event pattern based on one or more directional components of the first motion event, distinguishing the first motion event from a motion event initiated on a second side of the device, correlating a first operation with the first motion event pattern, and causing the first operation to be performed. The first operation may include causing the opacity of an image presented on a substantially transparent display to be increased.Type: GrantFiled: May 26, 2011Date of Patent: June 10, 2014Assignee: Nokia CorporationInventors: Syed Reza Ali, Sean Michael White
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Patent number: 8509137Abstract: An intentional presence system in accordance with the present invention includes a transmitting device at a first physical location that is responsive to a command intentionally initiated by a first individual at the first physical location to develop a presence signal intended for a second individual at a second physical location. The intentional presence system further includes a receiving device located at the second physical location which is receptive to the presence signal and which is operative to generate an indication to the second individual of the first individual's presence with respect to the transmitting device.Type: GrantFiled: August 12, 2011Date of Patent: August 13, 2013Assignee: Interval Licensing LLCInventors: Debby Hindus, Elaine Brechin, Jesse L. Dorogusker, Anna E. Hagstrom, Scott D. Mainwaring, Oliver T. Bayley, Sigrid Moeslinger, Colin Burns, Donald C. Jackson, Steve Guilhamet, Brian J. Fogg, Sean Michael White