Abstract: A system may include a 3D core design engine and a 3D core printing engine. The 3D core design engine may be configured to determine, in a CAD model, an under-core ply of a composite part and a core footprint on the under-core ply specified for an additive 3D core to be manufactured via additive manufacturing for insertion into the composite part, compute a bottom core surface of the additive 3D core from the under-core ply and core footprint, access core design parameters for the additive 3D core; and construct an additive 3D core design in the CAD model based on the computed bottom core surface and the core shape parameters. The 3D core printing engine may be configured to store the additive 3D core design to support subsequent manufacture of the additive 3D core via additive manufacturing.

Abstract: A system may include a 3D core design engine and a 3D core printing engine. The 3D core design engine may be configured to determine, in a CAD model, an under-core ply of a composite part and a core footprint on the under-core ply specified for an additive 3D core to be manufactured via additive manufacturing for insertion into the composite part, compute a bottom core surface of the additive 3D core from the under-core ply and core footprint, access core design parameters for the additive 3D core; and construct an additive 3D core design in the CAD model based on the computed bottom core surface and the core shape parameters. The 3D core printing engine may be configured to store the additive 3D core design to support subsequent manufacture of the additive 3D core via additive manufacturing.

Abstract: A device for the real-time in vivo detection of a number of conditions within the patient, including CTCs, circulating nucleic acids, other circulating elements, blood pressure, heart rate data, pulse oxygen concentration, serum electrolyte concentrations, blood glucose, and pH, the device having an implanted subcutaneous access port in the chest region and a catheter having a terminus in the superior vena cava, the device having microelectronic circuitry with a rechargeable energy source encased in a titanium shell, an NIR laser sealed in the titanium-enclosed circuitry platform, and NIR-specific optical fibers (nir-FO) for transmitting the NIR photons to the end of the catheter tube in the superior vena cava. Scattered NIR photons are collected through the end of a second nir-FO bundle and transmitted back to the detector and microprocessor on the portal platform.

Abstract: A device for the real-time in vivo detection of a number of conditions within the patient, including CTCs, circulating nucleic acids, other circulating elements, blood pressure, heart rate data, pulse oxygen concentration, serum electrolyte concentrations, blood glucose, and pH, the device having an implanted subcutaneous access port in the chest region and a catheter having a terminus in the superior vena cava, the device having microelectronic circuitry with a rechargeable energy source encased in a titanium shell, an NIR laser sealed in the titanium-enclosed circuitry platform, and NIR-specific optical fibers (nir-FO) for transmitting the NIR photons to the end of the catheter tube in the superior vena cava. Scattered NIR photons are collected through the end of a second nir-FO bundle and transmitted back to the detector and microprocessor on the portal platform.