Abstract: A medical stent may include a tubular support structure including a plurality of struts defining a plurality of cells disposed between the plurality of struts. A polymeric coating may be disposed over the tubular support structure such that a first portion of the plurality of cells are closed by the polymeric coating in a first region of the tubular support structure and a second portion of the plurality of cells in a second region of the tubular support structure remain open to fluid flow and/or tissue ingrowth therethrough. The struts in the first region of the tubular support structure and the struts in the second region of the tubular support structure may be at least partially covered by the polymeric coating.

Abstract: A combined system for diagnostic and therapeutic procedures includes a needle extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough, the distal end including a sharp grind for cutting a tissue sample to be collected in the lumen of the needle and a protective sheath sized and shaped to be inserted through the lumen of the needle such that a distal end of the protective sheath extends distally past the distal end of the needle, the protective sheath extending longitudinally from a proximal end to the distal end and including a lumen extending therethrough.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: Systems and methods for treating tissue may include one or more delivery devices, a grasping element, a first ring for anchoring to a wall of a gastrointestinal tract, and a second ring operably couplable to a radially inward surface of the first ring. Other embodiments include methods of treating tissues, including tubular tracts of tissue, comprising coupling a first ring to first tissue of a wall of a tissue tract, relocating a target tissue proximally to a position proximal to the first ring, coupling a second ring to the first ring, and cutting tissue proximal to the interface of the first and second rings.

Abstract: A combined system for diagnostic and therapeutic procedures includes a needle extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough, the distal end including a sharp grind for cutting a tissue sample to be collected in the lumen of the needle and a protective sheath sized and shaped to be inserted through the lumen of the needle such that a distal end of the protective sheath extends distally past the distal end of the needle, the protective sheath extending longitudinally from a proximal end to the distal end and including a lumen extending therethrough.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: Devices, systems, and methods for delivering targeted therapy to tissue at a treatment site with the use of a stent. The targeted therapy may include a functional and/or therapeutic agent separate from the stent, or a component of a functional and/or therapeutic agent separate from the stent and reactive with another component of a functional and/or therapeutic agent on the stent. The agent or component of an agent may be delivered with the stent, and/or before delivery of the stent, and/or after the stent has been delivered.

Abstract: Devices, systems, and methods described herein relate to affecting an internal diameter of a body lumen, and, in many examples, of a pylorus. A silk-based bulking agent may be injected in a pyloric tissue so as to reduce an effective inner diameter of the pylorus. A multi-part occluding agent may be injected into a pylorus on the surface of the pyloric tissue to occlude the pylorus alone or in combination with the silk-based bulking agent.

Abstract: The present application relates to medical devices for establishing an anastomosis between body lumens. In one example, an elongate member is configured to move between a first configuration and a second configuration. The elongate member may comprise a first end, a second end, and a middle segment extending therebetween. In the second configuration, each of the first and second ends may bend towards a center plane of the middle segment in a bent back end and form one or more loops.

Abstract: An implantable device capable of regulating flow of material through a body passage. The implantable device may include at least one retention member having a surface curved to resist migration of the implantable device with respect to the body passage. The implantable device may be provided with features providing a cushioning effect with respect to tissue at which the implantable device is implanted. The length of the implantable device and/or the configuration of at least one retention member on the implantable device may be adjustable. A removal element may be provided to facilitate removal of the implantable device.

Abstract: A mesh element having a mesh gauge selected to control flow of materials therethrough. The mesh element is implantable into an anatomical structure upstream of a body passage or within a body passage to control flow of materials through the body passage. The mesh element may be coupled to a support structure to facilitate anchoring of the mesh element in place relative to the body passage. The support structure may have a lumen defined therethrough to allow flow of materials through the body passage, with the mesh element regulating the flow of materials into the lumen. The mesh element alternatively may be directly coupled to an anatomical structure upstream of a body passage to regulate or determine flow of materials through the body passage.

Abstract: A system for measuring a pressure in a vein includes a needle sized and shaped to be inserted through a working channel of an endoscope. The needle is extending longitudinally and including a channel extending longitudinally therethrough. The system also includes a pressure sensing device including a longitudinally extending body sized and shaped to be slidably inserted through the channel of the needle and a sensor mounted on a distal portion of the body and connected to a proximal portion of the pressure sensing device via a connection cable. The sensor is configured to detect information corresponding to a pressure of a flow of blood through a vein.

Abstract: Devices, systems, and methods for drawing tissue walls together using a first tissue anchoring element and a second tissue anchoring element spaced apart from each other. The first tissue anchoring element is thinner than the second tissue anchoring element. The first tissue anchoring element may be a suture, optionally including a suture anchor. The second tissue anchoring element may be an expandable tissue anchoring element, such as a stent, expandable from a delivery configuration to a deployed configuration. The second tissue anchoring element may have a passage therethrough allowing passage of materials through the tissue walls, and creating an anastomosis therebetween.

Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: The present disclosure relates to systems and methods for enhanced navigation and visualization of body passages. In particular, the systems and methods of the present disclosure provide enhanced navigation through the pulmonary peripheries, and enhanced visualization within larger pulmonary passages.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction delivery device includes a positioning assembly, the assembly including: a delivery catheter having a distal end region and a lumen extending therein, wherein the distal end region includes an engagement member orienting tip. The delivery device also includes an actuation catheter extending within at least a portion of the delivery catheter, the actuation catheter including a distal end region and a lumen extending therein. An actuation wire extends within the lumen of the actuation catheter, the actuation wire having a proximal end region and a distal end region. An end effector is coupled to the distal end region of the actuation wire, the end effector configured to capture an engagement member of a tissue retraction device, wherein manipulation of the actuation wire shifts the end effector from a first position to a second closed position.

Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

Abstract: The present disclosure relates to systems and methods for enhanced navigation and visualization of body passages. In particular, the systems and methods of the present disclosure provide enhanced navigation through the pulmonary peripheries, and enhanced visualization within larger pulmonary passages.

Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.