Abstract: Solid pharmaceutical compositions of MRTX1133 (4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1Hpyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol), including capsule and tablet formulations; methods for preparing these compositions, and methods of their use for the treatment of various diseases and disorders.

Abstract: An aircraft emergency guidance assembly adapted to be mounted in an aircraft cabin comprises a longitudinally extending layer of photoluminescent material and a cover over the photoluminescent material. The assembly has a height and a width and a ratio of the width to height is from 0.5:1 to 3.5:1.

Abstract: An aircraft cabin lighting system comprises one or more cabin lighting units, each cabin lighting unit comprising an emergency exit sign arranged to be electrically illuminated using an aircraft electricity supply connected thereto; and one or more internally-powered emergency exit signs. The internally-powered emergency exit signs are portable, and each comprise an adhesive layer arranged to allow the internally-powered emergency exit sign to be adhered to a surface. The signs are arranged to be adhered to a surface in the vicinity of the connected electrical emergency exit sign in use, and do not require any external source of electricity to function.

Abstract: An aircraft cabin lighting system comprises one or more cabin lighting units, each cabin lighting unit comprising an emergency exit sign arranged to be electrically illuminated using an aircraft electricity supply connected thereto; and one or more internally-powered emergency exit signs. The internally-powered emergency exit signs are portable, and each comprise an adhesive layer arranged to allow the internally-powered emergency exit sign to be adhered to a surface. The signs are arranged to be adhered to a surface in the vicinity of the connected electrical emergency exit sign in use, and do not require any external source of electricity to function.

Abstract: An aircraft cabin lighting system comprises one or more cabin lighting units, each cabin lighting unit comprising an emergency exit sign arranged to be electrically illuminated; and one or more luminescent emergency exit signs. The luminescent emergency exit signs are portable, and each comprise an adhesive layer arranged to allow the luminescent emergency exit sign to be adhered to a surface. The signs are arranged to be adhered to a surface in the vicinity of the electrical emergency exit sign in use, and do not require electricity to function.

Abstract: An aircraft cabin lighting system comprises one or more cabin lighting units, each cabin lighting unit comprising an emergency exit sign arranged to be electrically illuminated; and one or more luminescent emergency exit signs. The luminescent emergency exit signs are portable, and each comprise an adhesive layer arranged to allow the luminescent emergency exit sign to be adhered to a surface. The signs are arranged to be adhered to a surface in the vicinity of the electrical emergency exit sign in use, and do not require electricity to function.

Abstract: A marker is arranged to indicate the presence of ultraviolet radiation. The marker includes at least an emitting layer having a fluorescent material arranged to emit visible light in a first range of wavelengths in response to excitation by ultraviolet radiation in a second range of wavelengths. The emission of visible light is reversible, and the marker is reusable. The marker may be a warning sign, and may be adhered to a surface or incorporated into a freestanding portable apparatus.

Abstract: An aircraft emergency guidance assembly adapted to be mounted in an aircraft cabin comprises a longitudinally extending layer of photoluminescent material and a cover over the photoluminescent material. The assembly has a height and a width and a ratio of the width to height is from 0.5:1 to 3.5:1.

Abstract: An aircraft emergency sign comprising a base layer comprising a photoluminescent material arranged to be charged by electromagnetic wavelengths in a first range and arranged to emit electromagnetic emissions in a second range; a barrier layer; and a print layer, the print layer being printed with at least one of a color or a pattern wherein the print layer is above the barrier layer and on a side remote from the base layer, and wherein the print layer is at least semi-transparent to wavelengths in the first range and the second range, the sign further comprising a mask layer provided between the barrier layer and the print layer.

Abstract: A method of manufacturing an aircraft photoluminescent marker that comprises a substrate includes providing an ink or coating adapted to be cured with ultra violet (UV) radiation and printing one or more markings directly onto the substrate of the photoluminescent marker with the ink or coating, followed by curing the ink or coating with UV radiation. The substrate is one of a photoluminescent material or a housing, and the marking comprises at least one of a pattern, wording, images, blocks, or indicia.

Abstract: A marker is arranged to indicate the presence of ultraviolet radiation. The marker includes at least an emitting layer having a fluorescent material arranged to emit visible light in a first range of wavelengths in response to excitation by ultraviolet radiation in a second range of wavelengths. The emission of visible light is reversible, and the marker is reusable. The marker may be a warning sign, and may be adhered to a surface or incorporated into a freestanding portable apparatus.

Abstract: An aircraft emergency sign comprising a base layer comprising a photoluminescent material arranged to be charged by electromagnetic wavelengths in a first range and arranged to emit electromagnetic emissions in a second range; a barrier layer; and a print layer, the print layer being printed with at least one of a color or a pattern wherein the print layer is above the barrier layer and on a side remote from the base layer, and wherein the print layer is at least semi-transparent to wavelengths in the first range and the second range, the sign further comprising a mask layer provided between the barrier layer and the print layer.

Abstract: An aircraft includes an aircraft cabin having a number of rows of seats, at least one aisle, and at least one exit. An emergency lighting system having a first and second lines on opposing sides of the aisle, each line comprising a non-continuous series of photoluminescent markers separated by at least a longitudinal distance in the direction of the respective line. An exit path identifier is arranged to guide passengers from the aisle to the exit. Each line comprises an alternating series of first and second markers. The first photoluminescent markers have a first length and the second markers have a second length, the first length either the same as or shorter than the second length. At least the second markers are located on or adjacent to a seat adjacent to the aisle and the first markers are arranged to block the non-exit paths.

Abstract: A photoluminescent aircraft floor path marking system includes at least a flexible track having a housing incorporating a flexible, pliable, photoluminescent portion in which the track is bendable to a radius of 1 m or less and the track has a length of at least 2 m, where the track is pliable such that it can retain a rolled or bent radius. The track may be bendable to a radius of from 0.01 m to 1.0 m or optionally from 0.01 m to 0.5 m. The flexible track may be provided in lengths of from 3 m or greater or greater than 10 m. A flexible protective layer may be provided. The flexible housing may include a holder for the photoluminescent material.