Patents by Inventor Sean Paul Palecek

Sean Paul Palecek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
    Patent number: 9765299
    Abstract: Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/?-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting Gsk-3 to obtain a first population of cells. Wnt/?-catenin signaling is then inhibited in the first cell population to induce cardiogenesis. One or more of these steps is performed under defined, albumin-free culture conditions.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: September 19, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sean Paul Palecek, Xiaojun Lian, Xiaoping Bao
  • Simplified methods for generating endothelial cells from human pluripotent stem cells under defined conditions
    Patent number: 9290741
    Abstract: Methods for generating human endothelial cells from human pluripotent stem cells under defined conditions in the absence of VEGF are described. Wnt/?-catenin signaling is activated in human pluripotent stem cells for a defined period, e.g., by inhibition of Gsk3, and then cultured without further exogenous activation of Wnt/?-catenin signaling to obtain a cell population containing human endothelial cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 22, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Sean Paul Palecek, Xiaojun Lian, Xiaoping Bao
  • CHEMICALLY DEFINED ALBUMIN-FREE CONDITIONS FOR CARDIOMYOCYTE DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20160068814
    Abstract: Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/?-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting Gsk-3 to obtain a first population of cells. Wnt/?-catenin signaling is then inhibited in the first cell population to induce cardiogenesis. One or more of these steps is performed under defined, albumin-free culture conditions.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 10, 2016
    Inventors: Sean Paul Palecek, Xiaojun Lian, Xiaoping Bao
  • Simplified Methods For Generating Endothelial Cells From Human Pluripotent Stem Cells Under Defined Conditions
    Publication number: 20140287498
    Abstract: Methods for generating human endothelial cells from human pluripotent stem cells under defined conditions in the absence of VEGF are described. Wnt/?-catenin signaling is activated in human pluripotent stem cells for a defined period, e.g., by inhibition of Gsk3, and then cultured without further exogenous activation of Wnt/?-catenin signaling to obtain a cell population containing human endothelial cells.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Sean Paul Palecek, Xiaojun Lian, Xiaoping Bao