Abstract: A data stream processors transition system which implements techniques for transitioning control from a first data stream processor to a second data stream processor. The data stream processors transition system preserves the integrity of data streams produced by first and second data stream processors when transitioning control between the first to the second data stream processors. For example, timestamp information may be provided to the first data stream processor that specifies when the first data stream processor may transfer control to the second data stream processor. The first data stream processor may process events by consuming and publishing results until the time specified by the timestamp information. The second data stream processor may, after the time specified by the timestamp information, process events by consuming and publishing results.

Abstract: Techniques for monitoring performance of a computer system are provided. Bucket data is stored that indicates that multiple buckets are associated with a particular type of request. Then, multiple requests are received, where a first request and a second request indicate the same type of request. Based on the bucket data, the first request is assigned to a first bucket and the second request is assigned to a second bucket. The assignment may be further based on a complexity determined for each request. First performance data is generated while processing the first request and is aggregated with second performance data that was generated while processing one or more third requests that are assigned to the first bucket. Third performance data is generated while processing the second request and aggregated with fourth performance data that was generated while processing one or more fourth requests that are assigned to the second bucket.

Abstract: A data stream processors transition system which implements techniques for transitioning control from a first data stream processor to a second data stream processor. The data stream processors transition system preserves the integrity of data streams produced by first and second data stream processors when transitioning control between the first to the second data stream processors. For example, timestamp information may be provided to the first data stream processor that specifies when the first data stream processor may transfer control to the second data stream processor. The first data stream processor may process events by consuming and publishing results until the time specified by the timestamp information. The second data stream processor may, after the time specified by the timestamp information, process events by consuming and publishing results.

Abstract: Techniques for monitoring performance of a computer system are provided. Bucket data is stored that indicates that multiple buckets are associated with a particular type of request. Then, multiple requests are received, where a first request and a second request indicate the same type of request. Based on the bucket data, the first request is assigned to a first bucket and the second request is assigned to a second bucket. The assignment may be further based on a complexity determined for each request. First performance data is generated while processing the first request and is aggregated with second performance data that was generated while processing one or more third requests that are assigned to the first bucket. Third performance data is generated while processing the second request and aggregated with fourth performance data that was generated while processing one or more fourth requests that are assigned to the second bucket.

Abstract: The present invention includes a composition comprising a compound, such as a 2,4,6-triamino-1,3,5-triazine, 2,4,6-triaminopyrimidine, 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine or 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine, that is useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention. The present invention further includes a method of preventing destabilizing or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention.

Abstract: The present invention includes a composition comprising a compound, such as a 2,4,6-triamino-1,3,5-triazine, 2,4,6-triaminopyrimidine, 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine or 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine, that is useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention. The present invention further includes a method of preventing destabilizing or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention.

Abstract: The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

Abstract: The present invention provides a novel fluid separator apparatus adapted for us with a multi-well plate. The separator is preferably adapted to separate fluid from particulate, amorphous or viscous material present in the fluid. The separator may be used in biological, immunological, histological biomarker and genomic detection assays and screening assays as well as for medical and chemical applications.