Abstract: A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.

Abstract: A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4r and about 0.8r, or between about 0.4r and about 0.6r.

Abstract: A panel assembly comprising at least two SIP panels fixedly coupled together in a coplanar relationship by a coupling apparatus for fixedly coupling an edge surface of a first SIP panel to an edge surface of a second SIP panel in an abutting relationship so that the two SIP panels are coplanar. The coupling apparatus comprising at least one staple having a bridge and two embedding elements spaced apart along the length of the bridge. Each embedding element being adapted to embed into one of the two SIP panels so that the staple bridges the abutting edges and fixedly couples the two abutting SIP panels together in a coplanar relationship.

Abstract: A downhole logging tool and method of use for analysing portions of a seafloor borehole in seafloor drilling operations are provided. The downhole logging tool h an underwater chassis housing a power system and sensors including at least a conductivity sensor and a magnetic susceptibility sensor which, preferably, analyse the walls of the borehole. An automatically actuated switch, preferably actuated magnetically, provides power to the sensors from the power system when the downhole logging tool is not located in a designated portion of a seafloor drilling rig (e.g. when the tool is in use traversing a borehole) and removes power when the downhole logging tool is located in the designated portion of the seafloor drilling rig (e.g. when the downhole tool is not in use).

Abstract: A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.

Abstract: The invention is drawn to particles for oral drug delivery produced by spray-drying a dilute solution of a poorly soluble agent. The particles comprise regions of poorly soluble agent wherein the dissolution rate enhancement is between about 2-fold and about 25-fold compared to the agent in bulk form.

Abstract: The invention provides an imprinted matrix which exhibits selective binding interactions through metal chelates with a predetermined molecule or biological particle. Also provided is a preformed, fluid-imprinted matrix having sufficient rigidity to maintain selective binding interaction with a predetermined molecule or biological particle through interactive moieties. Methods for producing such matrices are additionally provided.