Patents by Inventor Sean Poust

Sean Poust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid polyketide synthases
    Patent number: 11505791
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: November 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • HTP GENOMIC ENGINEERING PLATFORM FOR IMPROVING FUNGAL STRAINS
    Publication number: 20220145288
    Abstract: A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.
    Type: Application
    Filed: January 26, 2022
    Publication date: May 12, 2022
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • HTP genomic engineering platform for improving fungal strains
    Patent number: 11242524
    Abstract: A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: February 8, 2022
    Assignee: Zymergen Inc.
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • HTP genomic engineering platform for improving fungal strains
    Patent number: 11180753
    Abstract: HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods can be carried out within optofluidic devices.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 23, 2021
    Assignee: Zymergen Inc.
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • HTP GENOMIC ENGINEERING PLATFORM FOR IMPROVING FUNGAL STRAINS
    Publication number: 20210284993
    Abstract: A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.
    Type: Application
    Filed: March 19, 2021
    Publication date: September 16, 2021
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • Liquid based selection and cell isolation
    Patent number: 11098279
    Abstract: Aspects of this disclosure relate to liquid-based workflows for strain engineering. In strain engineering, cells undergo a modification process to acquire a desired change or changes in the cells. Some of the cells accept the change or changes and some do not. Provided herein are liquid-based methods for selecting the population of cells that have accepted the change or changes. Also provided herein are liquid-based methods for removing markers from transformed cells and liquid-based methods for isolating clonally pure populations of cells.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 24, 2021
    Assignee: ZYMERGEN INC.
    Inventors: Sean Poust, Vytas SunSpiral, William Serber, Matthew Jonathan Myers, Sara da Luz Areosa Cleto, Philip Weyman
  • HTP genomic engineering platform for improving fungal strains
    Patent number: 10954511
    Abstract: A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: March 23, 2021
    Assignee: Zymergen Inc.
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • Producing adipic acid and related compounds using hybrid polyketide synthases
    Patent number: 10760069
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • Hybrid Polyketide Synthases
    Publication number: 20200270597
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: December 2, 2019
    Publication date: August 27, 2020
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • HTP GENOMIC ENGINEERING PLATFORM FOR IMPROVING FUNGAL STRAINS
    Publication number: 20200123535
    Abstract: The present disclosure provides a HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.
    Type: Application
    Filed: December 20, 2019
    Publication date: April 23, 2020
    Inventors: Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
  • HTP GENOMIC ENGINEERING PLATFORM FOR IMPROVING FUNGAL STRAINS
    Publication number: 20200071693
    Abstract: The present disclosure provides a HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.
    Type: Application
    Filed: October 11, 2019
    Publication date: March 5, 2020
    Inventors: Vytas Sunspiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areaosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir FONG, III
  • LIQUID BASED SELECTION AND CELL ISOLATION
    Publication number: 20200032356
    Abstract: Aspects of this disclosure relate to liquid-based workflows for strain engineering. In strain engineering, cells undergo a modification process to acquire a desired change or changes in the cells. Some of the cells accept the change or changes and some do not. Provided herein are liquid-based methods for selecting the population of cells that have accepted the change or changes. Also provided herein are liquid-based methods for removing markers from transformed cells and liquid-based methods for isolating clonally pure populations of cells.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 30, 2020
    Inventors: Sean Poust, Vytas SunSpiral, William Serber, Matthew Jonathan Myers, Sara da Luz Areosa Cleto, Philip Weyman
  • Hybrid polyketide synthases
    Patent number: 10494625
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: December 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Producing Adipic Acid and Related Compounds Using Hybrid Polyketide Synthases
    Publication number: 20180273930
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Application
    Filed: January 10, 2018
    Publication date: September 27, 2018
    Applicant: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • HYBRID POLYKETIDE SYNTHASES
    Publication number: 20170015990
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: May 2, 2016
    Publication date: January 19, 2017
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Hybrid polyketide synthases
    Patent number: 9334514
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: May 10, 2016
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • HYBRID POLYKETIDE SYNTHASES
    Publication number: 20130280766
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: October 31, 2011
    Publication date: October 24, 2013
    Applicant: The Regents of the Unversity of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev