Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: A method, apparatus, computer readable medium for maintaining a user profile at a web service, including receiving at least one search term from a mobile application, generating a profile associated with an identifier for the mobile application, and storing the received at least one search term from the mobile application in connection with the identifier in the profile. The web service may generate an anonymous identifier for the mobile application, wherein the at least one search term from the mobile application is stored in connection with the anonymous identifier in the profile. The web service may receive and store a location and other information from the mobile application. The profile may be updated so that additional searches can be performed based at least in part of the maintained profile.

Abstract: A method, apparatus, and computer program product for performing region monitoring using tag matching to more closely match the monitored regions to a user's preference. A user enters user tags of interest, which are persisted to the region monitoring web server. The web server returns the closest regions having a region tag matching user tag first and the closest regions without matching tags secondary. An application at the mobile device then performs region monitoring of the identified closest region(s). When the mobile device enters a monitored region, it reports this event to the web server. The web server then determines whether any messages and/or assets associated with the region have matching message tags or asset tags and returns such messages or assets to the mobile device.

Abstract: A method, apparatus, and computer program product for performing region monitoring using tag matching to more closely match the monitored regions to a user's preference. A user enters user tags of interest, which are persisted to the region monitoring web server. The web server returns the closest regions having a region tag matching user tag first and the closest regions without matching tags secondary. An application at the mobile device then performs region monitoring of the identified closest region(s). When the mobile device enters a monitored region, it reports this event to the web server. The web server then determines whether any messages and/or assets associated with the region have matching message tags or asset tags and returns such messages or assets to the mobile device.

Abstract: A method, apparatus, and computer program product for performing region monitoring using tag matching to more closely match the monitored regions to a user's preference. A user enters user tags of interest, which are persisted to the region monitoring web server. The web server returns the closest regions having a region tag matching user tag first and the closest regions without matching tags secondary. An application at the mobile device then performs region monitoring of the identified closest region(s). When the mobile device enters a monitored region, it reports this event to the web server. The web server then determines whether any messages and/or assets associated with the region have matching message tags or asset tags and returns such messages or assets to the mobile device.

Abstract: A method, apparatus, computer readable medium for maintaining a user profile at a web service, including receiving at least one search term from a mobile application, generating a profile associated with an identifier for the mobile application, and storing the received at least one search term from the mobile application in connection with the identifier in the profile. The web service may generate an anonymous identifier for the mobile application, wherein the at least one search term from the mobile application is stored in connection with the anonymous identifier in the profile. The web service may receive and store a location and other information from the mobile application. The profile may be updated so that additional searches can be performed based at least in part of the maintained profile.

Abstract: A method, apparatus, and computer program product for reducing battery consumption while performing region monitoring. A mobile device requests, from a web server, N regions to be monitored within a circle having a first radius centered at a current location of the mobile device. The mobile device receives at most N closest regions and a second radius, wherein a personal region comprises an area of a circle having the second radius and centered at the current location of the mobile device. The second radius may be the same or different from the first radius. The mobile device monitors an updated location of the mobile device with respect to the previously defined personal region. The mobile device performs region monitoring of the received regions. When it is determined that the mobile device exits the personal region, requesting, from the web server, an update of the regions to be monitored.

Abstract: A method, apparatus, and computer program product for performing region monitoring using tag matching to more closely match the monitored regions to a user's preference. A user enters user tags of interest, which are persisted to the region monitoring web server. The web server returns the closest regions having a region tag matching user tag first and the closest regions without matching tags secondary. An application at the mobile device then performs region monitoring of the identified closest region(s). When the mobile device enters a monitored region, it reports this event to the web server. The web server then determines whether any messages and/or assets associated with the region have matching message tags or asset tags and returns such messages or assets to the mobile device.

Abstract: A method, apparatus, and computer program product for reducing battery consumption while tracking a location of a mobile device. A location tracking application at the mobile device registers to receive location updates from the mobile device. The application receives a location update from the mobile device and determines whether to transmit location information from the received location update to a remote web server.

Abstract: A method, apparatus, and computer program product for reducing battery consumption while performing region monitoring. A mobile device requests, from a web server, N regions to be monitored within a circle having a first radius centered at a current location of the mobile device. The mobile device receives at most N closest regions and a second radius, wherein a personal region comprises an area of a circle having the second radius and centered at the current location of the mobile device. The second radius may be the same or different from the first radius. The mobile device monitors an updated location of the mobile device with respect to the previously defined personal region. The mobile device performs region monitoring of the received regions. When it is determined that the mobile device exits the personal region, requesting, from the web server, an update of the regions to be monitored.

Abstract: A method, apparatus, and computer program product for reducing battery consumption while tracking a location of a mobile device. A location tracking application at the mobile device registers to receive location updates from the mobile device. The application receives a location update from the mobile device and determines whether to transmit location information from the received location update to a remote web server.