Patents by Inventor Sean Stromberg

Sean Stromberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230227900
    Abstract: A method for determining the presence of an allele, including (a) binding a polymerase to a double stranded nucleic acid that includes a primer hybridized to a template, the template including a first allele of a locus; (b) adding a nucleotide to the primer via catalytic activity of the polymerase, thereby producing an extended nucleic acid; (c) dissociating the polymerase from the extended nucleic acid; (d) detecting dissociation of the polymerase from the extended nucleic acid; and (e) comparing the dissociation of the polymerase from the extended nucleic acid to dissociation of the polymerase from a second double stranded nucleic acid, the second double stranded nucleic acid including a primer hybridized to the same position of the locus as the primer of the extended nucleic acid.
    Type: Application
    Filed: September 27, 2022
    Publication date: July 20, 2023
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Denis MALYSHEV, Sean STROMBERG
  • Publication number: 20230151420
    Abstract: A method of determining a nucleic acid sequence that includes steps of: (a) contacting a primed template nucleic acid with a series of mixtures for forming ternary complexes, wherein each of the mixtures includes a polymerase and nucleotide cognates for at least two different base types suspected of being present at the next template position of the template nucleic acid; (b) monitoring the next template position for ternary complexes formed by the series of mixtures, wherein a signal state indicates presence or absence of ternary complex formed at the next template position by each individual mixture, thereby determining a series of signal states that encodes a base call for the next template position; and (c) decoding the series of signal states to distinguish a correct base call for the next template position from an error in the base call.
    Type: Application
    Filed: July 29, 2022
    Publication date: May 18, 2023
    Inventors: Sean STROMBERG, John VIECELI, Kandaswamy VIJAYAN, Arnold OLIPHANT
  • Patent number: 11492666
    Abstract: A method for determining the presence of an allele, including (a) binding a polymerase to a double stranded nucleic acid that includes a primer hybridized to a template, the template including a first allele of a locus; (b) adding a nucleotide to the primer via catalytic activity of the polymerase, thereby producing an extended nucleic acid; (c) dissociating the polymerase from the extended nucleic acid; (d) detecting dissociation of the polymerase from the extended nucleic acid; and (e) comparing the dissociation of the polymerase from the extended nucleic acid to dissociation of the polymerase from a second double stranded nucleic acid, the second double stranded nucleic acid including a primer hybridized to the same position of the locus as the primer of the extended nucleic acid.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: November 8, 2022
    Assignee: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: Denis Malyshev, Sean Stromberg
  • Publication number: 20220305492
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: February 11, 2022
    Publication date: September 29, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20220297125
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: February 3, 2022
    Publication date: September 22, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Patent number: 11447823
    Abstract: A method of determining a nucleic acid sequence that includes steps of: (a) contacting a primed template nucleic acid with a series of mixtures for forming ternary complexes, wherein each of the mixtures includes a polymerase and nucleotide cognates for at least two different base types suspected of being present at the next template position of the template nucleic acid; (b) monitoring the next template position for ternary complexes formed by the series of mixtures, wherein a signal state indicates presence or absence of ternary complex formed at the next template position by each individual mixture, thereby determining a series of signal states that encodes a base call for the next template position; and (c) decoding the series of signal states to distinguish a correct base call for the next template position from an error in the base call.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: September 20, 2022
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Sean Stromberg, John Vieceli, Kandaswamy Vijayan, Arnold Oliphant
  • Publication number: 20220266250
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: February 11, 2022
    Publication date: August 25, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20220226825
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: February 3, 2022
    Publication date: July 21, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20220176374
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: August 20, 2021
    Publication date: June 9, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20220176375
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 9, 2022
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Patent number: 11351543
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: June 7, 2022
    Assignee: 1859, Inc.
    Inventors: Devon Cayer, Andrew MacConnell, Pavel Chubukov, Ramesh Ramji, Sean Stromberg
  • Patent number: 11351544
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: June 7, 2022
    Assignee: 1859, Inc.
    Inventors: Devon Cayer, Andrew MacConnell, Pavel Chubukov, Ramesh Ramji, Sean Stromberg
  • Patent number: 11247209
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: February 15, 2022
    Assignee: 1859, Inc.
    Inventors: Devon Cayer, Andrew MacConnell, Pavel Chubukov, Ramesh Ramji, Sean Stromberg
  • Patent number: 11123735
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: September 21, 2021
    Assignee: 1859, Inc.
    Inventors: Devon Cayer, Andrew MacConnell, Pavel Chubukov, Ramesh Ramji, Sean Stromberg
  • Publication number: 20210106999
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 15, 2021
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20210107000
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 15, 2021
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20210106996
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20210107004
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 15, 2021
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20210107002
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 15, 2021
    Inventors: Devon Cayer, Andrew Macconnell, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG
  • Publication number: 20210107003
    Abstract: Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 15, 2021
    Inventors: Devon CAYER, Andrew MACCONNELL, Pavel CHUBUKOV, Ramesh RAMJI, Sean STROMBERG