Patents by Inventor Sean W. Smith

Sean W. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Devices, systems and methods for endovascular temperature control
    Patent number: 11951035
    Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: April 9, 2024
    Assignee: ZOLL Circulation, Inc.
    Inventors: Jeremy Thomas Dabrowiak, Jessica Megan Clayton, John Thomas Buckley, Christo P. Pamichev, Craig Wendell Pendry, Paul Eric Peterson, Richard Allen Smith, Sean W. Yip, John William Jacobsen
  • ANTI-ASGR1 ANTIBODY CONJUGATES AND USES THEREOF
    Publication number: 20230062712
    Abstract: The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 2, 2023
    Inventors: Peter R. Baum, Robert Dubose, Valerie Odegard, Philip Tan, Peter A. Thompson, Sean W. Smith, Brenda Stevens
  • Anti-ASGR1 antibody TLR8 agonist comprising conjugates and uses thereof
    Patent number: 11541126
    Abstract: The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: January 3, 2023
    Assignee: SILVERBACK THERAPEUTICS, INC.
    Inventors: Peter R. Baum, Robert Dubose, Valerie Odegard, Philip Tan, Peter A. Thompson, Sean W. Smith, Brenda Stevens
  • TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF
    Publication number: 20210130473
    Abstract: Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGF?R1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.
    Type: Application
    Filed: October 9, 2020
    Publication date: May 6, 2021
    Inventors: Peter R. BAUM, Robert DUBOSE, Valerie ODEGARD, Philip TAN, Peter A. THOMPSON, Sean W. SMITH, Brenda STEVENS
  • ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
    Publication number: 20200061079
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Application
    Filed: June 27, 2019
    Publication date: February 27, 2020
    Inventors: Jagath R. JUNUTULA, Sean W. SMITH, Dmitry BORKIN, Sylvia DEGRADO, Sanjeevani GHONE
  • Isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers
    Patent number: 10350218
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: July 16, 2019
    Assignee: Cellerant Therapeutics, Inc.
    Inventors: Jagath R. Junutula, Sean W. Smith, Dmitry Borkin, Sylvia Degrado, Sanjeevani Ghone
  • ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
    Publication number: 20180177795
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Application
    Filed: February 23, 2018
    Publication date: June 28, 2018
    Inventors: Jagath R. JUNUTULA, Sean W. Smith, Dmitry Borkin, Sylvia Degrado, Sanjeevani Ghone
  • Indole derivatives and methods for antiviral treatment
    Patent number: 8735414
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: May 27, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Malcolm MacCoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT
    Publication number: 20120184574
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 19, 2012
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Malcolm Maccoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W. Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu