Abstract: Provided herein are methods and systems for producing a modified biological dataset by flagging or removing a nucleic acid sequence from the biological dataset that is assigned a noise-call to produce the modified biological dataset. The noise-call may be based on comparing a gene expression level, sequence information, or a combination thereof with a nucleic acid sequence of a control sample.

Abstract: Disclosed is a pool jet fitting configured to direct flow of water in a closed loop pool pumping filtration system. The pool jet fitting may include a housing and a valve positioned in the housing. The housing may include a housing body that defines a bore that extends through the housing body. The valve may be positioned in the bore of the housing and may be configured to receive water flow from a water pump. The valve may define an adjustable opening having a dimension capable of automatically adjusting between a first dimension and a second dimension to facilitate a predetermined outflow velocity of the water received from the pump.

Abstract: The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.

Abstract: Disclosed herein are systems and methods that automatically identify instances where a site of a business merchant being analyzed for a test event is involved in another test event affecting a similar category of item that is being analyzed during a same time frame. The algorithm executed to automatically identify concurring events occurring at the same site calculates each event's date range, marks events as overlapping based on date range and primary category of items affected, and then determines concurring items in concurring events. The concurring events identified are accounted for in forecasting a lift over a baseline forecast in response to a promotion to estimate the effects of each promotion independently.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header molded to the device housing. The header can be formed of an epoxy header material. A header component can have a first part molded in the header material to fix the header component to the header at a surface of the header and a second part extending out of the header material.

Abstract: Compositions and methods are provided to provide an expression signature for a sample, where an alternative splicing index and profile are determined for the sample based on variations in the splicing of messenger RNA for at least one gene in the sample.

Abstract: Provided herein are methods, systems and kits for stratification of risk of disease occurrence of a sample obtained from a subject by combining two or more feature spaces to improve individualization of subject management.

Abstract: The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header molded to the device housing. The header can be formed of an epoxy header material. A header component can have a first part molded in the header material to fix the header component to the header at a surface of the header and a second part extending out of the header material.

Abstract: A pool jet fitting can include an insert housing defining an insert body, a housing channel, and a base disposed within the housing channel. The base can include an outer sidewall that defines an internal chamber. The fitting has a valve disposed within the internal chamber. The valve includes a valve body, a valve channel that extends into the valve body along the first direction, and a valve opening that extends through the valve body and into the valve channel along a second direction that is angularly offset with respect to the first direction. The valve is movable between a first position whereby the valve opening has a first area through which the water flow moves and a second position whereby the valve opening has a second area through which the water flow moves that is greater than the first area.

Abstract: A rebar structure for concrete reinforcement may include an elongate tubular central wall portion having an inside surface and an outside surface. The central wall portion may be formed circumferentially around a core axis and may include glass or carbon fibers mostly being oriented longitudinally parallel to the core axis. The rebar structure may include an inner wall portion bonded to the inside surface of the central wall portion. The inner wall portion may include glass or carbon fibers and may have a higher percentage of fibers oriented non-parallel to the core axis as compared to the central wall portion.

Abstract: A rebar structure for concrete reinforcement may include an elongate tubular central wall portion having an inside surface and an outside surface. The central wall portion may be formed circumferentially around a core axis and may include glass or carbon fibers mostly being oriented longitudinally parallel to the core axis. The rebar structure may include an inner wall portion bonded to the inside surface of the central wall portion. The inner wall portion may include glass or carbon fibers and may have a higher percentage of fibers oriented non-parallel to the core axis as compared to the central wall portion.

Abstract: A method includes providing a mold defining a mold cavity for receiving material to be molded into a molded part, positioning an insert at least partially in the mold such that a portion of the insert defines a portion of the mold cavity, and injecting the material into the mold cavity to substantially fill the mold cavity to form the molded part. The molded par can then be removed from the mold and the insert can be removed from the molded part. The mold can include silicone and the insert can include polyoxymethylene.

Abstract: An implantable pulse generator includes a core assembly, a seal plug, and an outer layer overmolded over the core assembly adjacent the seal plug. The core assembly defines a core hole extending through the core assembly from a core interior to a core outer surface. The core hole has a hole outer portion and a hole inner portion. A first diameter of the hole outer portion is less than a second diameter of the hole inner portion. The seal plug is positioned in the core hole and has a plug outer portion aligned with the hole outer portion and a plug inner portion aligned with the hole inner portion. A third diameter of the plug outer portion is less than a fourth diameter of the plug inner portion. The outer layer leaves a top of the seal plug exposed.

Abstract: A method includes providing a mold defining a mold cavity for receiving material to be molded into a molded part, positioning an insert at least partially in the mold such that a portion of the insert defines a portion of the mold cavity, and injecting the material into the mold cavity to substantially fill the mold cavity to form the molded part. The molded par can then be removed from the mold and the insert can be removed from the molded part. The mold can include silicone and the insert can include polyoxymethylene.

Abstract: A lead connector assembly for an Implantable Medical Device (IMD) is disclosed. The lead connector assembly includes a rigid elongated connector core having a core opening along its long axis. An alternating series of elastomer seals and header contacts are inserted into the core opening along the long axis and meet with an end stop to hermetically self-align the header contacts with contact openings along the sides of the core. A connector block can be inserted into an opening in the connector core, and sealed with an adhesive. Once the connector core, header contacts, seals, and connector block are subassembled, the connector core subassembly may be hermitically tested, and thereafter affixed to other subassemblies by affixing means on the connector cores. Feedthrough pins can then be connected to the header contacts through the contact openings, and overmolded with a header to the IPG's case.

Abstract: An implantable pulse generator includes a core assembly, a seal plug, and an outer layer overmolded over the core assembly adjacent the seal plug. The core assembly defines a core hole extending through the core assembly from a core interior to a core outer surface. The core hole has a hole outer portion and a hole inner portion. A first diameter of the hole outer portion is less than a second diameter of the hole inner portion. The seal plug is positioned in the core hole and has a plug outer portion aligned with the hole outer portion and a plug inner portion aligned with the hole inner portion. A third diameter of the plug outer portion is less than a fourth diameter of the plug inner portion. The outer layer leaves a top of the seal plug exposed.

Abstract: A flow control device includes a body having an inner and an outer surface that oppose each other. The body may have a first opening and a second opening spaced from the first opening along a first axis. The inner surface may define a passage that extends from the first opening to the second opening along the first axis. The body may also include an inlet port between the first opening and the second opening, and a constriction in the passage between the first opening and the second opening. The flow control device may also comprise a nozzle disposed at least partially in the inlet port and extend at least partially across the passage along a second axis that is angularly offset with respect to the first axis. The nozzle may define an exit port in the passage.

Abstract: Disclosed is a pool jet fitting configured to direct flow of water in a closed loop pool pumping filtration system. The pool jet fitting may include a housing, and a valve positioned in the housing. The housing may include a housing body that defines a bore that extends through the housing body. The housing body may include a coupler that is configured to mate with a coupler of a wall mount so as to releasably couple the housing to the wall mount. The valve may be positioned in the bore of the housing and may be configured to receive water flow from a water pump. The valve may define an adjustable opening having a dimension capable of automatically adjusting between a first dimension and a second dimension to facilitate a predetermined outflow velocity of the water received from the pump.

Abstract: A rebar structure for concrete reinforcement may include an elongate tubular central wall portion having an inside surface and an outside surface. The central wall portion may be formed circumferentially around a core axis and may include glass or carbon fibers mostly being oriented longitudinally parallel to the core axis. The rebar structure may include an inner wall portion bonded to the inside surface of the central wall portion. The inner wall portion may include glass or carbon fibers and may have a higher percentage of fibers oriented non-parallel to the core axis as compared to the central wall portion.