Abstract: Apparatus and methods to permanently attach fuel delivery system components to fuel tanks are described herein. An example apparatus includes an insert material integrally formed with at least a portion of the fuel tank. The insert material includes a first layer material having a low permeation characteristic and a second layer material adjacent the first layer material having a relatively lower melting point than a melting point of the first layer material to enable permanent attachment of a coupling apparatus to a surface of the fuel tank by melting at least a portion of the second layer material.

Abstract: Venting systems for use with fuel tank systems are described. An example venting system includes a membrane disposed within a vent line or an emission control component to form a passageway through the venting system. The membrane is coated with a hydrophobic material to substantially prevent the flow of liquid and permit the flow of vapors or gases through the passageway.

Abstract: Fuel fill apparatus for use with fuel tanks are described. An example fuel fill apparatus includes a body to removably couple to a neck of a fuel tank. The body has an opening to receive a fuel nozzle and guide liquid fuel from the fuel nozzle to a cavity of the fuel tank. A nozzle retainer retains the fuel nozzle in the opening. A positioner in the opening offsets the fuel nozzle relative to a central axis of the opening such that an aspirator of the fuel nozzle is positioned adjacent an inner wall of the opening when the fuel nozzle is inserted in the opening. The positioner maintains a fuel nozzle outlet opening substantially parallel relative to a central axis of the opening during a fueling event.

Abstract: Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.

Abstract: Inlet control valves for use with fuel delivery systems are described. An example inlet control valve includes a first body portion having a first coupling to define an inlet of the control valve and one of a plurality of fasteners or a plurality of slots opposite the inlet. A second body portion coupled to the first body portion to define a fluid flow passageway, where the second body portion has a second coupling to define an outlet of the control valve and the other one of the plurality of fasteners or the plurality of slots opposite the outlet. The first plurality of slots receives the first plurality of fasteners when the first body portion is coupled to the second body portion. A valve is pivotally coupled relative to the first and second body portions to control fluid flow through the passageway.

Abstract: The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of manufacturing and methods of use.

Abstract: The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of manufacturing and methods of use.

Abstract: Apparatus and methods to couple fuel delivery system components to fuel tanks are described herein. An example liquid containment apparatus includes a fuel tank having a cavity to store a liquid fuel. The fuel tank includes only one opening in fluid communication with the cavity. A coupling apparatus is coupled to a portion of the fuel tank to provide a passage between an exterior surface of the fuel tank and the cavity. The coupling receives a plurality of components of a fuel delivery system.

Abstract: Pressure relief apparatus for use with fuel delivery systems are described herein. An example pressure relief apparatus includes a pressure relief system coupled to a body of a fuel cap to define a first side of the body and a second side of the body. The pressure relief system comprises a plurality of fluid valves to enable fluid flow from the first side of the body to the second side of the body when a first pressure differential across the pressure relief system from the first side to the second side is greater than a first reference pressure and to enable fluid flow from the second side of the body to the first side of the body when a second pressure differential across the pressure relief system from the second side to the first side is greater than a second reference pressure.

Abstract: Overflow prevention apparatus for use with fuel tanks are described herein. An example overflow prevention apparatus includes a fluid coupling configured to fluidly couple a fluid tank to a liquid fill passage. The fluid coupling includes a first portion configured to receive a liquid via the liquid fill passage and a second elongate portion configured to convey the liquid received via the liquid fill passage to the fluid tank. The second elongate portion has an aperture adjacent an end of the second portion. Also, the second portion is configured to extend into the fluid tank to prevent at least one of a gas or vapor from flowing between the fluid tank and the liquid fill passage when a liquid in the fluid tank is in the aperture.

Abstract: Apparatus and methods for mounting fuel delivery system components to fuel tanks are described herein. An example fuel tank includes a housing having a cavity to store a liquid fuel and a boss integrally formed with and protruding from a surface of the housing to receive a fuel delivery system component. The boss receives a threaded fastener to couple the fuel delivery system component to the surface of the fuel tank.

Abstract: Apparatus and methods to permanently attach fuel delivery system components to fuel tanks are described herein. An example apparatus includes an insert material integrally formed with at least a portion of the fuel tank. The insert material includes a first layer material having a low permeation characteristic and a second layer material adjacent the first layer material having a relatively lower melting point than a melting point of the first layer material to enable permanent attachment of a coupling apparatus to a surface of the fuel tank by melting at least a portion of the second layer material.

Abstract: An apparatus for treating an occlusion in a vessel inside of a patient. The apparatus includes an external high intensity focused ultrasound transducer configured to be positioned outside of the vessel and to emit ultrasonic waves of energy to the occlusion and to detect ultrasonic waves of energy, an internal ultrasound transducer configured to be positioned inside of the vessel at a position adjacent to or inside the occlusion and to emit ultrasonic waves of energy for detection by the external high intensity focused ultrasound transducer, and a controller configured to control the ultrasonic waves of energy emitted by the external high intensity focused ultrasound transducer based on an electrocardiogram of the patient.

Abstract: An intraluminal access and imaging device is configured to image a path of a vessel that includes a chronic total occlusion. The device includes an elongated member having a distal end and a proximal end. The distal end is configured to pass through an inner layer of the vessel so that the elongated member may track subintimally along a side of the chronic total occlusion. The elongated member includes a radiopaque material configured to be highly visible under fluoroscopy.

Abstract: A probe for detecting at least one property of a chronic total occlusion in a lumen. The probe includes an elongated member having a distal end configured to be inserted into the lumen, and an ultrasound transducer mounted at the distal end of the elongated member. The ultrasound transducer is configured to emit an ultrasonic signal and to receive a reflected signal from the chronic total occlusion. The probe also includes a processor configured to receive the reflected signal from the ultrasound transducer and convert the reflected signal to at least one property of the chronic total occlusion.

Abstract: Fuel cap apparatus for use with fuel venting systems are described. An example fuel cap apparatus includes a body having a central cavity and a flange. A membrane is coupled to the body to form a passageway therethrough and coated with a material to substantially prevent the flow of liquid and permit the flow of gas through the passageway.

Abstract: Venting systems for use with fuel tank systems are described. An example venting system includes a membrane disposed within a vent line or an emission control component to form a passageway through the venting system. The membrane is coated with a hydrophobic material to substantially prevent the flow of liquid and permit the flow of vapors or gases through the passageway.

Abstract: The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of manufacturing and methods of use.

Abstract: Disclosed herein are removable devices adapted to allow localized and contained delivery of bioactive materials to a treatment site within a lumen such as a blood vessel such that the flow of fluid through the lumen is not blocked during bioactive material delivery.

Abstract: The present invention concerns a mechanism for securely mounting an expandable stent onto a balloon catheter for intraluminal delivery within a patient. The stent is secured to the balloon of the delivery catheter by forming the surface of the balloon to project into the interstices of the stent. To mount the stent it first is slid over an evacuated and wrapped balloon while in its compact delivery diameter. A rigid tube then is placed over the stent and balloon assembly and the balloon is pressurized while a solvent is applied to the balloon. The rigid tube prevents the stent from expanding but allows the balloon to deform so that its surface projects slightly through either or both of the interstices and ends of the stent. The solvent causes the balloon material to take a permanent set into the stent such that once pressure is removed, the stent is interlocked with the surface of the balloon.