Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: A filter housing for containing a cartridge assembly having a filter cartridge secured to a filter cover, the filter housing has a peripheral wall extending around a longitudinal axis, and end wall secured to the peripheral wall, the filter housing defining a cavity partially enclosed by the peripheral wall and the end wall, the peripheral wall defining a cartridge-receiving section extending from the end wall along the longitudinal axis and sized for receiving the filter cartridge and a cover-receiving section extending along the longitudinal axis from the cartridge-receiving section to an open end of the filter housing opposed to the end wall and sized for receiving the filter cover, a portion of the cover-receiving section recessed radially outwardly from the cartridge-receiving section relative to the longitudinal axis, a lubricant outlet of the filter housing extending through the portion of the cover-receiving section of the peripheral wall.

Abstract: Proposed is an automated system providing an automatable long-term care risk mitigation structure associated with immediate care needs of risk-exposed individuals in case of becoming a long-term care-receiver. The system provides an automated multi-step trigger and detection cycle based on sensory measuring data for risk-exposed individuals thereby mitigating possibly occurring long-term care needs by means of the automated system based on a detected sufficient state of disability, possibly predetermined up-front amount parameters and an assigned care equity ratio associated with an asset. The state of disability of the risk-exposed individual is measurable by a definable set of risk-exposed individual measuring parameters.

Abstract: A system may perform a search from a source node of a node map to a target node of the node map. Performing the search may include identifying a first path, starting at the source node, that enters a particular constraint region, and identifying a second path, starting at the source node, that does not enter the particular constraint region. The system may select the second path as a path from the source node to the target node, based on identifying that the first path enters the particular constraint region and that the second path does not enter the particular constraint region. The system may cease exploring nodes via the first path when the second path is identified as reaching the target node, and not including a constraint associated with the particular constraint region.

Abstract: A system described herein may provide a technique for the generation of a node map using contraction hierarchy techniques in a manner that accounts for multi-link constraints. Multi-link constraints may include a sequence of two or more links through the node map, and paths that include such multi-link constraints may be associated with an additional cost based on such inclusion. Shortcut links that represent paths through nodes contracted out of the node map may be associated with portions of multi-link constraints. Paths through such shortcut links, where such paths include the remainder of the multi-link constraint, may be considered as including the multi-link constraint, and the cost of such paths may be calculated accordingly. The costs of links and/or paths, including paths that include multi-link constraints, may be used in determining a path from a source node to a target node of the node map.

Abstract: A device can determine scenario information associated with a plurality of route planning scenarios. The scenario information can include information that describes, for each route planning scenario of the plurality of route planning scenarios, a condition or a configuration based on which a respective route plan is to be generated. The device can calculate, based on a plurality of route plans corresponding to the plurality of route planning scenarios, a set of metrics associated with the plurality of route planning scenarios. The set of metrics can be calculated based on a single user interaction with a user interface. The device can provide information associated with the set of metrics. The providing the information associated with the set of metrics can cause an action, associated with at least one route plan of the plurality of route plans, to be automatically performed.

Abstract: A system described herein may provide a technique for a determination of a path through a node map using one or more searches. The nodes may be associated with respective priorities. A first search may be performed from a first node in ascending order of priority. A second search may be performed from a second node in ascending order of priority, until a third node, traversed during the first search is reached. A third search may be performed from the third node, in descending order of priority, until the first node is reached. The third search may be restricted only to nodes traversed during the first search. A path that is based on the second and third searches may be provided in response to a navigation request from a starting point associated with the second node to a destination associated with the first node.

Abstract: The present invention relates to devices and methods of use thereof for real time blood flow measurements of skin. In one embodiment, the device is a compact laser speckle imaging, or LSI, system that is integrated with a dermatoscope. In another embodiment, the device allows the user to diagnose a disease or condition in an individual, or as part of an overall treatment regimen.

Abstract: A device can determine scenario information associated with a plurality of route planning scenarios. The scenario information can include information that describes, for each route planning scenario of the plurality of route planning scenarios, a condition or a configuration based on which a respective route plan is to be generated. The device can calculate, based on a plurality of route plans corresponding to the plurality of route planning scenarios, a set of metrics associated with the plurality of route planning scenarios. The set of metrics can be calculated based on a single user interaction with a user interface. The device can provide information associated with the set of metrics. The providing the information associated with the set of metrics can cause an action, associated with at least one route plan of the plurality of route plans, to be automatically performed.

Abstract: A device can determine scenario information associated with a plurality of route planning scenarios. The scenario information can include information that describes, for each route planning scenario of the plurality of route planning scenarios, a condition or a configuration based on which a respective route plan is to be generated. The device can calculate, based on a plurality of route plans corresponding to the plurality of route planning scenarios, a set of metrics associated with the plurality of route planning scenarios. The set of metrics can be calculated based on a single user interaction with a user interface. The device can provide information associated with the set of metrics. The providing the information associated with the set of metrics can cause an action, associated with at least one route plan of the plurality of route plans, to be automatically performed.

Abstract: Disclosed herein are embodiments of a continuous analyte sensor that can be used to measure glucose or lactate levels in a patient, along with other analytes. In some embodiments, the sensor can be located in the tissue or a blood vessel of a patient, and a probe can be located on the skin of the patient generally adjacent to the sensor. The probe can detect luminescent signals that originate from the sensor and that are dependent on analyte levels.

Abstract: Aspects of the invention comprise methods and systems for collecting penetration tester data, i.e. data from one or more simulated hacker attacks on an organization's digital infrastructure in order to test the organization's defenses, and utilizing the data to train machine learning models which aid in documenting tester training session work by automatically logging, classifying or clustering engagements or parts of engagements and suggesting commands or hints for an tester to run during certain types of engagement training exercises, based on what the system has learned from previous tester activities, or alternatively classifying the tools used by the tester into a testing tool type category.

Abstract: A device can determine scenario information associated with a plurality of route planning scenarios. The scenario information can include information that describes, for each route planning scenario of the plurality of route planning scenarios, a condition or a configuration based on which a respective route plan is to be generated. The device can calculate, based on a plurality of route plans corresponding to the plurality of route planning scenarios, a set of metrics associated with the plurality of route planning scenarios. The set of metrics can be calculated based on a single user interaction with a user interface. The device can provide information associated with the set of metrics. The providing the information associated with the set of metrics can cause an action, associated with at least one route plan of the plurality of route plans, to be automatically performed.

Abstract: The present invention relates to devices and methods of use thereof for real time blood flow measurements of skin. In one embodiment, the device is a compact laser speckle imaging, or LSI, system that is integrated with a dermatoscope. In another embodiment, the device allows the user to diagnose a disease or condition in an individual, or as part of an overall treatment regimen.

Abstract: An apparatus, method, and computer program product are provided for generating a projected user interface. The apparatus may include at least one processor and at least one memory including computer program code. The at least one memory and the computer program code may be configured, with the processor, to cause the apparatus to receive information regarding a detected position of the user's body and to determine whether the detected position is an activation position, in which case the projection of a user interface may be provided. The user interface may be projected on an area on the user's body, such as a hand or a forearm, or on the surface of an object. The activation position may thus be a predefined position of the user's body in which effective projection of the user interface onto the surface and user interaction with the user interface is facilitated.

Abstract: Disclosed herein are embodiments of a continuous analyte sensor that can be used to measure glucose or lactate levels in a patient, along with other analytes. In some embodiments, the sensor can be located in the tissue or a blood vessel of a patient, and a probe can be located on the skin of the patient generally adjacent to the sensor. The probe can detect luminescent signals that originate from the sensor and that are dependent on analyte levels.

Abstract: An apparatus for measuring vital signs and various states of health using the underlying concept of Photoplethysmography (PPG). This apparatus comprises one or more light source(s) and one or more detector(s) configured to measure transmitted and/or reflected light within the digits such as a finger or toe, but can also be applied to other soft tissue elements. The apparatus comprises a means to enhance signal quality, control the volume of interrogated tissue and minimize motion artifact. The apparatus comprises a power source. The apparatus may further comprise at least one processor to receive information from the detector and process measured variations in light intensity. This information may be transmitted wirelessly through technology such as Bluetooth. The apparatus may also comprise a system utilizing inductive charging (“wireless charging”).

Abstract: A method, apparatus, and computer program product are provided to facilitate sharing of content between various computing devices. In the context of a method, an image of an external apparatus is received that includes information presented upon a display of the external apparatus. The method may also cause a content request to be provided that requests content upon which the information presented upon the display of the external apparatus is based. In response to the request, the method may receive the content upon which the information presented upon the display of the external apparatus is based.