Patents by Inventor Sean Winkle

Sean Winkle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GEMINIVIRAL VECTOR FOR EXPRESSION OF RITUXIMAB
    Publication number: 20190194680
    Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.
    Type: Application
    Filed: October 25, 2018
    Publication date: June 27, 2019
    Inventors: Hugh Mason, Charles Arntzen, Sun Hee Rosenthal, Sean Winkle, Andrew Diamos
  • Geminiviral vector for expression of rituximab
    Patent number: 10125373
    Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: November 13, 2018
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Hugh Mason, Charles Arntzen, Sun Hee Rosenthal, Sean Winkle, Andrew Diamos
  • GEMINIVIRAL VECTOR FOR EXPRESSION OF RITUXIMAB
    Publication number: 20150368660
    Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.
    Type: Application
    Filed: January 22, 2014
    Publication date: December 24, 2015
    Inventors: Hugh Mason, Charles Arntzen, Sun Hee Rosenthal, Sean Winkle, Andy Diamos