Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

Abstract: The present invention provides a novel biosynthetic production process which converts L-galactose into 2?-fucosyllactose via four enzymatically catalyzed reaction steps. The present process is designed such that co-factors required by the process are regenerated within the four reaction steps, hence making the process cost-effective and efficient. The process can be performed in vitro in a cell-free system. The present invention also provides mutant enzymes that can be used to increase production levels of 2?-fucosyllactose, whether using the novel pathway described herein or the mannose-dependent pathway known in the art.

Abstract: Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.

Abstract: In one aspect, the invention relates to substituted 4-phenoxyphenol analogs, derivatives thereof, and related compounds, which are useful as inhibitors of proliferating cell nuclear antigen (PCNA); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with PCNA using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.

Abstract: Various computer-implemented methods, carrier media, and systems for displaying an image of at least a portion of a wafer are provided. One computer-implemented method for displaying an image of at least a portion of a wafer includes separately storing different portions of an image of substantially an entire wafer acquired by inspection of the wafer. The different portions of the image correspond to different areas on the wafer. The method also includes displaying in a user interface (UI) only the different portions requested by a user.

Abstract: Various methods and systems for detection of selected defects particularly in relatively noisy inspection data are provided. One method includes applying a spatial filter algorithm to raw inspection data acquired across an area on a substrate to determine a first portion of the raw inspection data that has a higher probability of being a selected type of defect than a second portion of the raw inspection data. The selected type of defect includes a non-point defect. The method also includes generating a raw two-dimensional map illustrating the first portion of the raw inspection data. In addition, the method includes searching the raw two-dimensional map for an event that has spatial characteristics that approximately match spatial characteristics of the selected type of defect. The method further includes determining if the event corresponds to a defect having the selected type.

Abstract: Various methods and systems for detection of selected defects particularly in relatively noisy inspection data are provided. One method includes applying a spatial filter algorithm to raw inspection data acquired across an area on a substrate to determine a first portion of the raw inspection data that has a higher probability of being a selected type of defect than a second portion of the raw inspection data. The selected type of defect includes a non-point defect. The method also includes generating a raw two-dimensional map illustrating the first portion of the raw inspection data. In addition, the method includes searching the raw two-dimensional map for an event that has spatial characteristics that approximately match spatial characteristics of the selected type of defect. The method further includes determining if the event corresponds to a defect having the selected type.

Abstract: A system for analyzing noise sources correlates the sound pressure level value at any field point to the acoustic energy directly flowing out of any individual panel of a vibrating structure. This acoustic energy flow or acoustic intensity depicts how sound radiates and in which direction a sound wave propagates in the field. Therefore, the result represents a true contribution of an individual panel to an acoustic field. The acoustic intensity on the surface of a vibrating object is reconstructed by the Helmholtz equation least squares (HELS) based nearfield acoustical holography (NAH). The acoustic intensity is utilized to establish correlations between user-designated panels and the SPL value at any field point. With this information users can rank the order of contributions from individual panels of any vibrating structure to an acoustic field. These order ranking and panel contribution analyses help engineers to come up the best strategy to tackle various noise issues in the most cost-effective manner.

Abstract: A system provides an in situ or non-invasive vibro-acosutic (VA) analysis of an arbitrary complex vibrating structure. The major advantages of this system are that: (1) it allows for an identification of the VA modes that are directly responsible for structural vibration and sound radiation; (2) it enables one to acquire a quantitative description of contributions from individual VA modes that are responsible for resultant structural vibration and sound radiation; and (3) it is non-invasive so that one can conduct an in situ analysis of a machine running under its natural working condition. With this information, one can tackle noise and vibration problems in the most cost-effective manner.

Abstract: A system extracts the sound spectrum and sound pressure level (SPL) values of a target source in a non-ideal environment. This system can be critical for in-line or end-of-line quality control (QC) testing of sound-producing products in a manufacturing environment in which background noise level is high. The underlying principle of this system is the assumption that the sound field can be described using two sets of expansion functions, one for direct sound radiation from a target source and the other for the background sounds that travel in the opposite direction as that of direct sound from the target. The coefficients associated with these expansion functions are determined in a similar manner as those in the Helmholtz Equation Least Squares (HELS) method. Once the expansion coefficients are determined, however, only the direct sound spectrum and corresponding SPL value are displayed. This allows for suppression of background noise produced by the neighboring sources and reflections from nearby surfaces.

Abstract: An acoustic resonator device includes a semiconductor substrate, a FBAR (thin film bulk acoustic resonator) and a support plate. The FBAR is fabricated on the upper surface of the semiconductor substrate. The semiconductor substrate has a resonant cavity through the upper and the lower surfaces thereof. The support plate is attached to the lower surface of the semiconductor substrate to shelter the opening of the resonant cavity. Moreover, the support plate can provide a larger die-attaching area for the acoustic resonator device, for the protection of the resonant cavity from chipping during wafer sawing.

Abstract: An algorithm diagnoses the noise source strength distribution on an arbitrarily shaped object based on acoustic pressures measured in the far field, known as FANS. FANS enable one to acquire a quick estimate of the acoustic pressure at locations that are off limit to traditional measurement microphones. Generally, in the method of the present invention, the noise source is modeled in terms a plurality of virtual spherical wave sources distributed on an auxiliary surface conformal to a source boundary from the inside, but not on the source boundary itself. Sound is then measured at a plurality of measurement points external to the source boundary. The sound field is reconstructed on the source boundary surface itself.

Abstract: General algorithms are developed for reconstructing the acoustic field generated by an arbitrary object subject to an arbitrarily time-dependent excitation. These algorithms enable one to visualize a time-domain acoustic pressure wave as it travels through three-dimensional space. Such a tool can be used to diagnose general noise sources and transmission since in engineering applications most structures are subject to arbitrarily time-dependent excitations. To facilitate the derivations of the temporal solutions, we make use of Laplace transform and expand the acoustic pressure in terms of the spherical Hankel functions and the spherical harmonics. The expansion coefficients are settled by solving an over-determined system of equations obtained by matching the assumed-form solutions to the measured acoustic pressures.

Abstract: A technique for determining particulate density in a fluid monitors the changes in the speed of sound. Since the speed of sound is intimately related to the composites of the air mixture and since the speed of sound of clean air at any temperature and humidity can be calculated exactly, it is possible to estimate the density of any foreign particulates in the air by observing changes in the speed of sound. Formulations are derived that correlate the change in the speed of sound of the air mixture to their density fluctuations, thus allowing people to estimate the mass density of foreign particulates under any temperature and humidity. Alternatively, the change in density of the air mixture can be detected, thereby indicating the presence of contaminants and a possible alarm, even if the contaminants are not yet identified.

Abstract: The present invention provides a low cost, efficient vertical cavity surface emitting laser package (300) and manufacturing method, the package having a head assembly having at least three leads, a vertical cavity surface emitting laser die bonded to a top surface of the head assembly, for generating a beam of light, and a photodiode, die bonded to the top surface of the head assembly proximate to the vertical cavity surface emitting laser for receiving at least a portion of the beam of light, and generating feedback for adjusting an electrical input current to the vertical cavity surface emitting laser based on a received optical power of the portion of the beam of light received. The vertical cavity surface emitting laser and the photodiode are injection molded in a predetermined shape with a recessed area for placement of a partially reflective holographic optical element/reflector.