Patents by Inventor Sebastiaan Nijhuis

Sebastiaan Nijhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Measuring thrombin activity in whole blood
    Patent number: 8916356
    Abstract: The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within a range of 0.05 to 5 mm and a surface within a range of 10 to 500 mm2; —allowing thrombin to generate in said sample; —measuring the fluorescence emitted from the surface of the layer, by the fluorescent group released from the fluorogenic substrate as a result of enzymatic action of generated thrombin on said fluorogenic substrate.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: December 23, 2014
    Assignee: Synapse B.V.
    Inventors: Hendrik Coenraad Hemker, Suzette Beguin, Raed Al-Dieri, Robert Wagenvoord, Sebastiaan Nijhuis, Peter Giesen
  • Method and assembly for measuring thrombin generation in plasma
    Patent number: 8828730
    Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: September 9, 2014
    Assignee: Synapse B.V.
    Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
  • METHOD AND ASSEMBLY FOR MEASURING THROMBIN GENERATION IN PLASMA
    Publication number: 20110195441
    Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.
    Type: Application
    Filed: August 5, 2009
    Publication date: August 11, 2011
    Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
  • Measuring thrombin activity in whole blood
    Publication number: 20090311730
    Abstract: The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within a range of 0.05 to 5 mm and a surface within a range of 10 to 500 mm2; —allowing thrombin to generate in said sample; —measuring the fluorescence emitted from the surface of the layer, by the fluorescent group released from the fluorogenic substrate as a result of enzymatic action of generated thrombin on said fluorogenic substrate.
    Type: Application
    Filed: April 26, 2006
    Publication date: December 17, 2009
    Applicant: Synapse B.V.
    Inventors: Hendrik Coenraad Hemker, Suzette Beguin, Raed Al-Dieri, Robert Wagenvoord, Sebastiaan Nijhuis, Peter Giesen