Patents by Inventor Sebastian Bernhardt

Sebastian Bernhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11965199
    Abstract: Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: April 23, 2024
    Assignee: SANOFI
    Inventors: Claus Lattemann, Thomas Stillger, Bernd Janocha, Hans-Falk Rasser, Sebastian Rissom, Simone Anderko, Rita Bernhardt, Frank Hannemann
  • Patent number: 10919848
    Abstract: A process for preparing methionine includes the alkaline hydrolysis of 5-(2-methylmercaptoethyl)-hydantoin (methionine hydantoin) in an aqueous process solution containing alkali metal hydroxide and/or alkali metal carbonate and/or alkali metal hydrogencarbonate. The alkali metal cations in the process solution are potassium and sodium having a K/Na molar ratio range from 99/1 to 20/80.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: February 16, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Sebastian Bernhardt, Martin Körfer, Stefan Reichert, Hans-Joachim Hasselbach, Bernd Drapal, Rainer Peter, Christian Kaiser, Benny Hartono, Harald Jakob
  • Patent number: 10800736
    Abstract: A process is used for preparing methionine. Specifically, the process includes the hydrolysis of 5-(2-methylmercaptoethyl)hydantoin (methionine hydantoin) in an alkaline process solution. Further, the by-products that include formate and other anions of organic acids containing 1 to 5 carbon atoms are removed by electrodialysis of the process solution.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: October 13, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Daniel Fischer, Patrik Stenner, Sebastian Bernhardt, Harald Jakob
  • Publication number: 20200157045
    Abstract: A process is used for preparing methionine. Specifically, the process includes the hydrolysis of 5-(2-methylmercaptoethyl)hydantoin (methionine hydantoin) in an alkaline process solution. Further, the by-products that include formate and other anions of organic acids containing 1 to 5 carbon atoms are removed by electrodialysis of the process solution.
    Type: Application
    Filed: May 9, 2018
    Publication date: May 21, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Daniel Fischer, Patrik Stenner, Sebastian Bernhardt, Harald Jakob
  • Publication number: 20200039928
    Abstract: A process for preparing methionine includes the alkaline hydrolysis of 5-(2-methylmercaptoethyl)-hydantoin (methionine hydantoin) in an aqueous process solution containing alkali metal hydroxide and/or alkali metal carbonate and/or alkali metal hydrogencarbonate. The alkali metal cations in the process solution are potassium and sodium having a K/Na molar ratio range from 99/1 to 20/80.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 6, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Sebastian Bernhardt, Martin Körfer, Stefan Reichert, Hans-Joachim Hasselbach, Bernd Drapal, Rainer Peter, Christian Kaiser, Benny Hartono, Harald Jakob
  • Patent number: 9273070
    Abstract: Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: March 1, 2016
    Inventors: Paul Knochel, Sebastian Bernhardt, Georg Manolikakes
  • Publication number: 20140031545
    Abstract: Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 30, 2014
    Applicant: LUDWIG-MAXIMILIAN-UNIVERSITAT MUNCHEN
    Inventors: Paul Knochel, Sebastian Bernhardt, Georg Manolikakes