Abstract: A gear set arrangement (10) for a bicycle gearbox (400) includes a planetary assembly, a stationary component (24), a first and a second brake (B1, B2), and a first and a second freewheel clutch (F1, F2). One planetary gear set (12) of the planetary assembly includes a first rotary element, a second rotary element, and a third rotary element. The first rotary element is rotationally fixable on the stationary component (24) by the first brake (B1). The first rotary element is connectable to the output (36) by the first freewheel clutch (F1). The second rotary element is rotationally fixable on the stationary component (24) by the second brake (B2). The second rotary element is connectable to the output (36) by the second freewheel clutch (F2). The third rotary element is connected to the input (34) for conjoint rotation. The gear set arrangement (10) is configured to provide three ratios.

Abstract: A gear set arrangement (10) for a bicycle gearbox (400) includes a planetary assembly, a stationary component (24), a first and a second brake (B1, B2), and a first and a second freewheel clutch (F1, F2). One planetary gear set (12) of the planetary assembly includes a first rotary element, a second rotary element, and a third rotary element. The first rotary element is rotationally fixable on the stationary component (24) by the first brake (B1). The first rotary element is connectable to the output (36) by the first freewheel clutch (F1). The second rotary element is rotationally fixable on the stationary component (24) by the second brake (B2). The second rotary element is connectable to the output (36) by the second freewheel clutch (F2). The third rotary element is connected to the input (34) for conjoint rotation. The gear set arrangement (10) is configured to provide three ratios.

Abstract: The present invention relates to recombinant multi-specific proteins comprising binding agents with binding specificity for different targets, such as, e.g. CD3, CD33, CD123 and CD70. In addition, the invention relates to nucleic acids encoding such multi-specific proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, e.g. acute myeloid leukaemia (AML), in a mammal, including a human.

Abstract: The application relates to prodrugs comprising a drug molecule connected by a protease-cleavable peptide linker to a binder, which reversibly inhibits a biological activity of the drug molecule, and to the inhibitory binders themselves. Also described are nucleic acids encoding the recombinant proteins described herein, and methods of making said recombinant proteins, as well as methods of treatment and medical uses of the recombinant proteins.

Abstract: The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for CD3. In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods of disease-localized activation of T cells, and in methods of treating diseases, such as infectious diseases or cancer, in a mammal, including a human.

Abstract: The present invention relates to recombinant multi-specific proteins comprising binding agents with binding specificity for different targets, such as, e.g. CD3, CD33, CD123 and CD70. In addition, the invention relates to nucleic acids encoding such multi-specific proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, e.g. acute myeloid leukaemia (AML), in a mammal, including a human.

Abstract: The present invention relates to recombinant multi-specific proteins comprising binding agents with binding specificity for different targets, such as, e.g. CD3, CD33, CD123 and CD70. In addition, the invention relates to nucleic acids encoding such multi-specific proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, e.g. acute myeloid leukaemia (AML), in a mammal, including a human.

Abstract: A method of determining at least one of a rotational angle position and a rotational speed of a rotating element of a drive train includes arranging at least two sensors in an offset manner in a circumferential direction of the rotating element, recording a measured value indicative of a characteristic of a rotation of the rotating element with each sensor, and determining at least one of a rotational angle position and a rotational speed with reference to the measured values and a distance between the at least two sensors in the circumferential direction.

Abstract: The present invention relates to an innovative (meth)acrylic reactive resin which cures with low odor or odorlessly. The present invention relates more particularly to reactive resins comprising high-boiling, reactive (meth)acrylic monomers from the group of the polar, cyclically substituted esters of (meth)acrylic acid, more particularly glycerol acetal, ketal or carbonate methacrylates. These new components are used as substitutes for MMA, which represents the major part of the odor nuisance in the existing, prior-art reactive resin systems. Using these new components it is possible to obtain resin formulations which have glass transition temperatures similar to, and properties comparable with, MMA-based resins. The innovative reactive resins are able in addition to exhibit more rapid curing than prior-art MMA-based systems. Reactive resins for the purposes of the invention are reactive monomer mixtures or mixtures of monomers and polymers that when used as a 2-component system can be readily cured.

Abstract: A method of determining at least one of a rotational angle position and a rotational speed of a rotating element of a drive train includes arranging at least two sensors in an offset manner in a circumferential direction of the rotating element, recording a measured value indicative of a characteristic of a rotation of the rotating element with each sensor, and determining at least one of a rotational angle position and a rotational speed with reference to the measured values and a distance between the at least two sensors in the circumferential direction.

Abstract: A method for damping torsional oscillations in a drive train component, in particular a gearbox, in particular in a power production plant, includes adjusting a load on the output side in the drive train as a function of a difference between a rotational speed of an input shaft of the drive train component and a rotational speed of an output shaft of the drive train component.

Abstract: The present invention relates to an innovative (meth)acrylic reactive resin which cures with low odour or odourlessly. The present invention relates more particularly to reactive resins comprising high-boiling, reactive (meth)acrylic monomers from the group of the polar, cyclically substituted esters of (meth)acrylic acid, more particularly glycerol acetal, ketal or carbonate methacrylates. These new components are used as substitutes for MMA, which represents the major part of the odour nuisance in the existing, prior-art reactive resin systems. Using these new components it is possible to obtain resin formulations which have glass transition temperatures similar to, and properties comparable with, MMA-based resins. The innovative reactive resins are able in addition to exhibit more rapid curing than prior-art MMA-based systems. Reactive resins for the purposes of the invention are reactive monomer mixtures or mixtures of monomers and polymers that when used as a 2-component system can be readily cured.

Abstract: A method for damping torsional oscillations in a drive train component, in particular a gearbox, in particular in a power production plant, includes adjusting a load on the output side in the drive train as a function of a difference between a rotational speed of an input shaft of the drive train component and a rotational speed of an output shaft of the drive train component.

Abstract: The invention relates to a process for preparing binders for plastisols that ensures high and consistent product quality over a multiplicity of batches. The binders obtained from this process allow the formulation of plastisols which possess improved stability on storage and, after gelling, improved mechanical properties.