Abstract: A modular device for a fixed arrangement and interconnection of individual separation units and/or first functional units for performing one or more unit operations in a biotechnological process. The modular device includes a plurality of distributor caps provided for attachment to the separation units and/or first functional units. The distributor caps each have: a fluid distribution mechanism having a working connection and at least two supply or discharge connections, wherein the fluid distribution mechanism can assume at least two defined switching positions; connection mechanisms for establishing a flow communication between a fluid inlet or outlet of the separation unit or the first functional unit and the working connection of the fluid distribution mechanism; coupling mechanisms for establishing a rigid mechanical coupling and a flow communication with an adjacent distributor cap; and an interface for changing the switching positions of the fluid distribution mechanism.

Abstract: A distributor assembly, which is provided in particular for a separation unit of a modular process device arrangement, including a fluid distributor device having a plurality of fluid ports, wherein the fluid distributor device can selectively establish and block fluid communications between the fluid ports. The distributor assembly further includes a connecting element and a retaining element. The connecting element is adapted to be attached to one of the fluid ports, and the distributor assembly includes an associated mounting slot at the fluid port. The mounting slot is adapted to the shape of the retaining element such that the retaining element can be inserted into the mounting slot up to a defined retaining position, in which the retaining element engages the connecting element and fixes it in place.

Abstract: A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.

Abstract: A filtration device, in particular a disposable filtration device, has a flow path in which a filter element and an integrated flow reducer are arranged one behind the other. The flow reducer is adapted to be brought to a first operating position, which permits a defined first volume flow rate, and at least to a second operating position, which permits a defined second volume flow rate which is smaller than the first volume flow rate.

Abstract: A connection device has a line portion having, at its end, a radially outwardly projecting abutment flange for abutting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion, and a ring-segment chain comprising a plurality of ring segments connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which form the chain ends can be latched to one another to give a ring-form connection clamp. The line portion is designed in the form of a tubular connection stub with first thread means spaced apart axially from the abutment surface of its abutment flange and in that each ring segment has a radially inwardly projecting clamping flange and second thread means, which are spaced apart axially from said clamping flange and correspond to the first thread means.

Abstract: A single-use device for separating or purifying a large volume of a mixture of substances including membrane chromatography modules which are fixedly mounted in a predetermined grid and a line system for linking the membrane chromatography modules and for connecting the membrane chromatography modules to each other. A cover or bottom mechanism holding the membrane chromatography modules in position in a predetermined grid may be attached to the upper or lower side of the membrane chromatography modules. At least part of the line system is formed in the cover or the bottom mechanism, with connecting lines between the membrane chromatography modules. In a method of separating or purifying a large volume of a mixture of substances using such a single-use device having a plurality of automated valves and sensors connected to a control unit, the automated valves are controlled based on an evaluation of the parameters measured by the sensors.

Abstract: A filter module for sterile filtration and virus filtration of fluid media. The filter module includes a filter membrane with a porous edge structure arranged thereon and at least one anchoring element. The filter membrane with the porous edge structure is embedded in the anchoring element and serves as edge reinforcement to improve the connection of the filter membrane to the anchoring element. The texturing or surface roughness of the edge reinforcement provides an interlocking effect between the filter membrane and the anchoring element. The embedding of the filter membrane in the anchoring element provides a fluid-tight connection of the membrane to the anchoring element which prevents the occurrence of leaks in the end region of the filter module. A method for producing the filter module is also described.

Abstract: The invention relates to an annular connection clamp with a first clamping flange (22) which protrudes radially inwards and with an axial counter bearing (24) which is spaced from the clamping flange and which is made of a first and a second half-ring segment (20), each half-ring segment having a first and a second segment end. The first segment end of the first half-ring segment (20) has latching means (281) of a first type, and the second segment end of the second half-ring segment has corresponding latching means (282) of a second type, said latching means being pushed into each other in a tangential direction, thereby being latchable together. The second segment end of the half-ring segment (20) has latching means (282) of a second type, and the first segment end of the second half-ring segment (20) has latching means (281) of a first type, said latching means being pushed into each other in a tangential direction, thereby being latchable together.

Abstract: A connection device has a line portion having, at its end, a radially outwardly projecting abutment flange for abutting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion, and a ring-segment chain comprising a plurality of ring segments connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which form the chain ends can be latched to one another to give a ring-form connection clamp. The invention is distinguished in that the line portion is designed in the form of a tubular connection stub with first thread means spaced apart axially from the abutment surface of its abutment flange and in that each ring segment has a radially inwardly projecting clamping flange and second thread means, which are spaced apart axially from said clamping flange and correspond to the first thread means.

Abstract: The present invention relates to a porous sheet product, to a filter element comprising the porous sheet product, to a method for producing the porous sheet product, to a method for producing the filter element, and to the use of the sheet product and of the filter element.

Abstract: The invention relates to a connection device comprising —a line portion (10) having, at its end, a radially outwardly projecting abutment flange (14) for butting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion (10), and—a ring-segment chain (42, 22, 38) comprising a plurality of ring segments (22, 38) connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which formed the chain ends can be latched to one another to give a ring-form connection clamp (42). The invention is distinguished in that the line portion is designed in the form of a tubular connection stub (10) with first thread means (16) spaced apart axially from the abutment surface (141) of its abutment flange (14), and in that each ring segment (22, 38) has a radially inwardly projecting clamping flange (24) and second thread means (26), which are spaced apart axially from said clamping flange and correspond with the first thread means (16).

Abstract: A disposable filtration device includes a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder. At least the holder and the lines between the filter capsules preferably are formed of a sterilizable material, so that the filtration device can be sterilized in the pre-mounted, i.e. ready-to-connect condition, and can be packed and transported without a risk of damage.

Abstract: A filter module with a perforated inner tube (20) and a concentric, perforated outer tube (22), forming an interposed annular gap for a filter membrane (10) pleated into folds. The membrane folds (11, . . . ) are of different fold types with differing fold heights, extend from a respective fold edge (111, . . . ) resting against the outer tube towards the inner tube to the respective fold tip (114, . . . ) and are arranged along the circumference of the annular gap as groups of folds (11, . . . ) of different types. Each group has a mating fold (15) which extends from a mating fold edge (151) resting against the inner tube towards the outer tube to the mating fold tip (154). The height of the mating fold is no more than the difference between the width of the annular gap and the height of the fold type with the shortest height of the same group.

Abstract: A filter module having an edge-reinforced membrane, a method for producing the filter module, and the use thereof.

Abstract: The present invention relates to a micro-porous filtration membrane with performance enhancing projections as well as a method for producing the same.

Abstract: A filter module with a perforated inner tube (20) and a concentric, perforated outer tube (22), forming an interposed annular gap for a filter membrane (10) pleated into folds. The membrane folds (11, . . . ) are of different fold types with differing fold heights, extend from a respective fold edge (111, . . . ) resting against the outer tube towards the inner tube to the respective fold tip (114, . . . ) and are arranged along the circumference of the annular gap as groups of folds (11, . . . ) of different types. Each group has a mating fold (15) which extends from a mating fold edge (151) resting against the inner tube towards the outer tube to the mating fold tip (154. The height of the mating fold is no more than the difference between the width of the annular gap and the height of the fold type with the shortest height of the same group.

Abstract: The invention relates to a connection device comprising —a line portion (10) having, at its end, a radially outwardly projecting abutment flange (14) for butting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion (10), and —a ring-segment chain (42, 22, 38) comprising a plurality of ring segments (22, 38) connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which formed the chain ends can be latched to one another to give a ring-form connection clamp (42). The invention is distinguished in that the line portion is designed in the form of a tubular connection stub (10) with first thread means (16) spaced apart axially from the abutment surface (141) of its abutment flange (14), and in that each ring segment (22, 38) has a radially inwardly projecting clamping flange (24) and second thread means (26), which are spaced apart axially from said clamping flange and correspond with the first thread means (16).

Abstract: A filtration device, in particular a disposable filtration device, has a flow path in which a filter element and an integrated flow reducer are arranged one behind the other. The flow reducer is adapted to be brought to a first operating position, which permits a defined first volume flow rate, and at least to a second operating position, which permits a defined second volume flow rate which is smaller than the first volume flow rate.

Abstract: A single-use filtration device (10) comprises a plurality of single-use filter capsules (12) connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder (14). The filter capsules (12), in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules (12), are preconfigured for a desired filtration process.

Abstract: A disposable filter capsule for a filtration device comprises only one housing, which has an inflow connection for a fluid to be filtered and an outflow connection for filtrate. The disposable filter capsule also comprises at least two separate filter means, which are fixed in the housing and together with the housing form an inseparable structural unit. All the components of the disposable filter capsule consist of sterilizable, in particular gamma-sterilizable, materials.