Abstract: A pedal unit for a vehicle has a sensor surface which includes at least two functional regions and is designed to detect an actuation by the driver. The pedal unit also has at least one evaluation and control unit coupled to the sensor surface and designed to evaluate an actuation of one of the at least two functional regions detected by the sensor surface and, as a function of this evaluation, control a vehicle function associated with the corresponding functional region of the sensor surface. At least one region of the sensor surface is raised or lowered and enables a haptic differentiation between the at least two functional regions of the sensor surface.

Abstract: A method and system for determining a geographical location and orientation of a vehicle travelling through a road network is disclosed. The method comprises obtaining, from one or more cameras associated with the vehicle travelling through the road network, a sequence of images reflecting the environment of the road network on which the vehicle is travelling, wherein each of the images has an associated camera location at which the image was recorded. A local map representation representing an area of the road network on which the vehicle is travelling is then generated using at least some of the obtained images and the associated camera locations. The generated local map representation is compared with a section of a reference map, the reference map section covering the area of the road network on which the vehicle is travelling, and the geographical location and orientation of the vehicle within the road network is determined based on the comparison.

Abstract: A disclosed method for operating a treatment system and to a treatment system for electrophoretic dip coating, more particularly dip painting of a metal workpiece, more particularly of a vehicle body, in a dipping tank filled with a paint, wherein: a relative movement between the workpiece and a bus bar is carried out in the dipping tank; a voltage is applied to the workpiece; and, while the workpiece is in the effective range of at least one bus bar portion of the bus bar, electric current is fed to the workpiece from the at least one bus bar portion at least some of the time. Examples disclosed herein also relate to a treatment system and to a computer program product.

Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.

Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: Connection device for a stator having a stator winding, including N phases, first and second connection units which each comprise N contact portions and a conductor arrangement. The contact portions of the first connection unit are each designed for electrically conductive contacting of one of N connection portions of the stator winding, and the conductor arrangement of the first connection unit electrically conductively connects the contact portions of the first connection unit. The contact portions of the second connection unit are each designed for electrically conductive contacting of one of N further connection portions of the stator winding and the conductor arrangement of the second connection unit comprises N conductor portions, which are electrically insulated from each other and are each electrically conductively connected to one of the N contact portions of the second connection unit. A fastening mechanism permits the connection units to be detached and fastened.

Abstract: Connection unit for a stator with a stator winding having a number N of phases, having first to Nth contact portions, which are each designed for electrically conductively contacting one of N connection portions of the stator, form a receiving chamber for receiving one of the connection portions and have a guide. A respective contact portion has a wall, which limits the receiving chamber on one side, and the guide of the contact portion has a wall, which adjoins the wall of the contact portion and is bevelled with respect to the wall of the contact portion in a manner facing away from the receiving chamber. A conductor arrangement, which either electrically conductively connects the first to Nth contact portions or comprises N conductor portions, which are electrically isolated from one another and are each electrically conductively connected to one of the contact portions.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: Described is an electrical machine (1) which comprises two end shields (6, 7), a stator (5) which is arranged between the two end shields (6, 7) and has a stator laminated core (11, 11a) and stator windings (12) arranged therein, and a rotor (3) which is arranged in the stator (5) and has a rotor shaft (2) mounted rotatably in the two end shields (6, 7). The electrical machine (1) furthermore has cooling channels (13) arranged fully in the stator laminated core (11, 11a) and edged by the latter. Furthermore described are a gear motor (30) comprising such an electrical machine (1), as well as a vehicle (20) comprising such an electrical machine (1).

Abstract: The invention relates to an outer shell for a safety helmet (1), in particular for a motorcycle safety helmet, for distributing impact forces, said outer shell having an outer shell material (2). The outer shell is characterized in that, on a side (3) having the outer shell material (2) of the outer shell, the outer shell has a cover (4) having the outer shell material (2) in order to hold an antenna (5) between the cover (4) and the side (3). The invention further relates to a safety helmet (1) having such an outer shell and to a method for producing such an outer shell.

Abstract: The clamping device is provided for tools and has a coupling piece that is provided with at least one actuating unit. The coupling piece acts to actuate a nut seated on a spindle journal that is receiving the tool. A torque coupling is provided for the nut. The coupling piece is fixedly connected with an output shaft that is in drive connection with a drive shaft by a transmission gear. As a result of the transmission gear, it is possible to rotate the drive shaft with minimal moment in order to apply the great clamping force required for axial clamping of the tool.

Abstract: The clamping device is provided for tools and has a coupling piece that is provided with at least one actuating unit. The coupling piece acts to actuate a nut seated on a spindle journal that is receiving the tool. A torque coupling is provided for the nut. The coupling piece is fixedly connected with an output shaft that is in drive connection with a drive shaft by a transmission gear. As a result of the transmission gear, it is possible to rotate the drive shaft with minimal moment in order to apply the great clamping force required for axial clamping of the tool.

Abstract: A method of sorting a dataset includes incrementally receiving data from the dataset, and incrementally storing the received data as individual input data subsets as the data is received, thereby sequentially generating a plurality of filled data subsets of unsorted data. The method includes individually sorting each filled data subset of unsorted data concurrently with receiving data for a next one of the individual input data subsets, thereby sequentially generating a plurality of sorted input data subsets, and performing a merge sort on the plurality of sorted input data subsets, thereby incrementally generating a sorted version of the dataset.

Abstract: A method of sorting a dataset includes incrementally receiving data from the dataset, and incrementally storing the received data as individual input data subsets as the data is received, thereby sequentially generating a plurality of filled data subsets of unsorted data. The method includes individually sorting each filled data subset of unsorted data concurrently with receiving data for a next one of the individual input data subsets, thereby sequentially generating a plurality of sorted input data subsets, and performing a merge sort on the plurality of sorted input data subsets, thereby incrementally generating a sorted version of the dataset.