Abstract: The invention relates to EGFR targeting Fc antigen binding fragment-drug conjugates (EGFR Fcab-drug conjugates) and the use of the EGFR Fcab-drug conjugates of the present invention for the treatment and/or prevention of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such EGFR Fcab-drug conjugates. Further, the invention relates to EGFR Fcab-label conjugates and diagnostic compositions containing such EGFR Fcab-label conjugates.

Abstract: A stator assembly for a progressive cavity pump or a progressive cavity motor includes connectors for connecting functional elements and at least one stator, the stator including an outer pipe as well as a lining subject to wear which is disposed inside the outer pipe, the at least one stator being disposed between the connectors such that a cavity extending across the entire stator assembly for housing a rotor is created. Between at least one of the connectors and at least one stator adjacent thereto and/or between adjacent stators an adhesion region is provided, whereby in the adhesion region an adhesive is disposed in such a way that between the at least one connector and the at least one stator adjacent thereto and/or between said respectively adjacent stators a substance-to-substance connection is created.

Abstract: A stator assembly for a progressive cavity pump or a progressive cavity motor includes connectors for connecting functional elements and at least one stator, the stator including an outer pipe as well as a lining subject to wear which is disposed inside the outer pipe, the at least one stator being disposed between the connectors such that a cavity extending across the entire stator assembly for housing a rotor is created. Between at least one of the connectors and at least one stator adjacent thereto and/or between adjacent stators an adhesion region is provided, whereby in the adhesion region an adhesive is disposed in such a way that between the at least one connector and the at least one stator adjacent thereto and/or between said respectively adjacent stators a substance-to-substance connection is created.

Abstract: A drive unit for a grain elevator, in particular for agricultural machines, has a drive wheel operatively connected to a screw conveyor for conveying crop into the grain elevator. The drive wheel is provided with a retainer which may be engaged in a positive locking and/or friction-type connection with a continuous tension device of the grain elevator provided with one or more paddles so as to drive the continuous tension device. Several openings are provided in the drive wheel between the arms holding the retainer in such a way that this allows or facilitates crop conveyed by the screw conveyor into the grain elevator along a direction of conveyance to flow through the drive wheel.

Abstract: A drive unit for a grain elevator, in particular for agricultural machines, has a drive wheel operatively connected to a screw conveyor for conveying crop into the grain elevator. The drive wheel is provided with retainer means which may be engaged in a positive locking and/or friction-type connection with a continuous tension means of the grain elevator provided with one or more paddles so as to drive the continuous tension means. Several openings are provided in the drive wheel between the arms holding the retainer means in such a way that this allows or facilitates crop conveyed by the screw conveyor into the grain elevator along a direction of conveyance to flow through the drive wheel.

Abstract: The present disclosure relates to fusion proteins that are highly useful for the generation of virus-like particles for the display of membrane spanning proteins. Related embodiments, methods and uses are disclosed.

Abstract: The present disclosure relates to a method for determining a respective stem volume for each respective stem of an audio composition including a plurality of stems. A first value for each of one or more parameters is received for a first segment of the audio composition. For each respective stem of the audio composition, a first respective stem volume is determined for the first segment of the audio composition based on the one or more parameters and a volume control layer.

Abstract: The present disclosure provides a method to express and purify polypeptides and proteins. In the present disclosure the use of lysozyme as a fusion partner is disclosed. Furthermore, purification methods to isolate lysozyme-tagged polypeptides and proteins via lysozyme-specific antibodies are described. More specifically, the present disclosure provides a method to express and purify monomeric polypeptides and proteins by using lysozyme as a tag.

Abstract: The present disclosure relates to fusion proteins that are highly useful for the generation of virus-like particles for the display of membrane spanning proteins. Related embodiments, methods and uses are disclosed.

Abstract: The present disclosure provides a method to express and purify polypeptides and proteins. In the present disclosure the use of lysozyme as a fusion partner is disclosed. Furthermore, purification methods to isolate lysozyme-tagged polypeptides and proteins via lysozyme-specific antibodies are described. More specifically, the present disclosure provides a method to express and purify monomeric polypeptides and proteins by using lysozyme as a tag.

Abstract: A method for preparing an aqueous solution containing triterpenic acid, an aqueous solution containing triterpenic acid, and use thereof, includes preparation of a basic aqueous solution containing triterpenic acid and reduction of the pH of the basic aqueous solution containing triterpenic acid by adding an acidic aqueous solution in the presence of a stabilizing additive. The system may also provide an aqueous physiological solution of a plant extract containing triterpenic acid, a method for preparing same, and use thereof for therapeutic purposes that includes aqueous physiological solutions rich in triterpenic acid which includes pharmacologically effective amounts of triterpenic acids.