Patents by Inventor Sebastian Johannes Pomplun

Sebastian Johannes Pomplun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLEAVABLE LINKER FOR PEPTIDE SYNTHESIS
    Publication number: 20230159584
    Abstract: The present invention provides a new building block for peptide synthesis, which introduces a cleavage site that can be used to generate cleavable fragments subsequent to a peptide sequence.
    Type: Application
    Filed: November 15, 2022
    Publication date: May 25, 2023
    Inventors: Frank BERGMANN, Simon Ferdinand LOIBL, Sebastian Johannes POMPLUN
  • Cleavable linker for peptide synthesis
    Patent number: 11548911
    Abstract: The present invention provides a new building block for peptide synthesis, which introduces a cleavage site that can be used to generate cleavable fragments subsequent to a peptide sequence.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: January 10, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Frank Bergmann, Simon Ferdinand Loibl, Sebastian Johannes Pomplun
  • Method for labeling of aldehyde containing target molecules
    Patent number: 11293060
    Abstract: The present invention relates to improving the processing rate of a sequencing reaction, for example in a nanopore sequencing reaction, by means of using improved nucleoside-tags. The tags are linked to the nucleoside phosphate via a Pictet Spengler reaction. Exemplary sequencing reactions that are improved by the present methods include nanopore-based nucleic acid sequencing-by-synthesis reactions.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: April 5, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Frank Bergmann, Ian Quang Chau, Peter Crisalli, Hannah Marie Kallewaard-Lum, Hannes Kuchelmeister, Sebastian Johannes Pomplun, Hasham Saqib, Christian Wellner
  • HPLC FREE PURIFICATION OF PEPTIDES BY THE USE OF NEW CAPPING AND CAPTURE REAGENTS
    Publication number: 20220064212
    Abstract: The present disclosure relates to the use of a capping and capture reagent in solid phase peptide synthesis. The present disclosure further relates to a method of solid phase peptide synthesis, wherein a capping and capture reagent according to the present disclosure is used. The present disclosure further relates to a method for purification of a (full-length) synthetic peptide via use of a capping and capture reagent according to the present disclosure. The present disclosure also relates to a kit comprising a capping and capture reagent according to the present disclosure and an amino oxy resin or a hydrazine resin and the use of the kit.
    Type: Application
    Filed: January 3, 2020
    Publication date: March 3, 2022
    Inventors: Frank BERGMANN, Sebastian Johannes POMPLUN
  • Method for labeling of aldehyde containing target molecules
    Patent number: 11236386
    Abstract: The present description relates to a method for binding to a target molecule having an aldehyde compound derived from N-(2-aminoethyl)pyrrole, which compound also has a moiety of interest, to compounds (conjugates) obtained by this method, having both the target molecule and the moiety of interest and to novel substances derived from N-(2-aminoethyl)pyrrole.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: February 1, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Tobias Oelschlaegel, Sebastian Johannes Pomplun
  • CLEAVABLE LINKER FOR PEPTIDE SYNTHESIS
    Publication number: 20210155654
    Abstract: The present invention provides a new building block for peptide synthesis, which introduces a cleavage site that can be used to generate cleavable fragments subsequent to a peptide sequence.
    Type: Application
    Filed: February 8, 2021
    Publication date: May 27, 2021
    Inventors: Frank BERGMANN, Simon Ferdinand LOIBL, Sebastian Johannes POMPLUN
  • METHOD FOR LABELING OF ALDEHYDE CONTAINING TARGET MOLECULES
    Publication number: 20200140443
    Abstract: The present description relates to a method for binding to a target molecule having an aldehyde compound derived from N-(2-aminoethyl)pyrrole, which compound also has a moiety of interest, to compounds (conjugates) obtained by this method, having both the target molecule and the moiety of interest and to novel substances derived from N-(2-aminoethyl)pyrrole.
    Type: Application
    Filed: October 10, 2019
    Publication date: May 7, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Tobias Oelschlaegel, Sebastian Johannes Pomplun
  • METHOD FOR LABELING OF ALDEHYDE CONTAINING TARGET MOLECULES
    Publication number: 20200040392
    Abstract: The present invention relates to improving the processing rate of a sequencing reaction, for example in a nanopore sequencing reaction, by means of using improved nucleoside-tags. The tags are linked to the nucleoside phosphate via a Pictet Spengler reaction. Exemplary sequencing reactions that are improved by the present methods include nanopore-based nucleic acid sequencing-by-synthesis reactions.
    Type: Application
    Filed: October 8, 2019
    Publication date: February 6, 2020
    Inventors: Frank Bergmann, Ian Quang Chau, Peter Crisalli, Hannah Marie Kallewaard-Lum, Hannes Kuchelmeister, Sebastian Johannes Pomplun, Hasham Saqib, Christian Wellner