Abstract: A crosslinkable, heat-conducting silicone composition along with processes for producing and uses for the same. Where the composition includes 5-50% by volume of a crosslinkable silicone composition (S) and 50-95% by volume of at least one thermally conductive filler (Z) having a thermal conductivity of at least 5 W/mK. Where the crosslinkable heat-conducting silicone composition has a thermal conductivity of at least 0.6 W/mK and at least 20% by volume of metallic aluminum particles present as thermally conductive fillers (Z).

Abstract: Core-shell particles and processes for producing the same. Where the core-shell particles include a core (B) and a shell (D). The core (B) includes a thermoplastic polyester (C) with a melting range of lower than 160° C. and the shell (D) includes partially water-wettable particles (E) of metal oxide. Where the partially water-wettable particles (E) have a methanol value of less than 30 and the metal content of the core-shell particles (A) is at least 2.5% by weight.

Abstract: Crosslinkable heat-conducting silicone compositions (Y), methods for manufacturing and using the same. Where the compositions (Y) include 5-50% by volume of a crosslinkable silicone composition (S) and 50-95% by volume of at least one thermally conductive filler (Z) having a thermal conductivity of at least 5 W/mK. The compositions (Y) have a thermal conductivity of at least 0.6 W/mK and at least 20% by volume of metallic silicon particles present as thermally conductive fillers (Z) fulfil the following features: (a) the fillers (Z) have a median diameter x50 in the range of 30-150 ?m, (b) the fillers (Z) are predominately rounded, and have a width/length ratio (aspect ratio w/l) that is at least 0.76, (c) the fillers (Z) have a distribution range SPAN ((x90?x10)/x50) that is at least 0.40, and (d) the fillers (Z) contain at most 1.5% by weight of silicon particles that are smaller than 2 ?m.

Abstract: An aqueous, particle-stabilized Pickering emulsion along with methods or processes for producing the same and particles produced therefrom.

Abstract: Particles P and methods of making the same. The particles P are composed of a core K comprising crosslinked silicone elastomer composition X and of a shell H of silica S. Where the core K includes a reinforcing filler F which is selected from pyrogenic or precipitated hydrophobic silicas having DIN 66131 BET surface areas of at least 50 m2/g and also from carbon blacks and activated carbons and silicone resins.

Abstract: A process for preparing spherical silicone resin particles in which alkoxysilanes are reacted with water to form a hydrolysate is provided. The resulting silicone resin particles are isolated from a mixture. The silicone resin particles are dried and the particles are deagglomerated by ultrasonic sieving.

Abstract: The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non-physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention.

Abstract: A compound of the formula: wherein R1 is selected from H, methyl, ethyl, carboxyl protecting groups and hydrophilic moieties, R2 and R3 are independently selected from H, methyl, ethyl and carboxyl protecting groups, R4 is selected from H, methyl, ethyl, hydrophilic moieties and carboxyl protecting groups, and R5 is an aryl, heteroaryl, alkyl or a combination of these groups and is substituted with a carbonyl group, an aminooxy group or a functional group suitable for participating in a cycloaddition reaction. The compounds of the invention may be useful as bifunctional chelating agents which allow chemoselective attachment to targeting molecules.

Abstract: The present invention pertains to compounds that show a high affinity to Factor VIII and Factor VIII-like proteins, and their uses. The compounds are characterized by the general Formula B-Q-X, wherein B represents a dipeptide, tripeptide, or a peptidomimetic; Q represents a spacer and X represents an anchoring molecule; Q and X are optional. These compounds can be used for coating a solid support material. The resulting coated solid support material can be used for purifying Factor VIII by means of affinity chromatography methods. In addition, the compounds of the present invention may be used for stabilizing Factor VIII and for enhancing its activity. The present invention thus pertains also to methods for manufacturing a stabilized Factor VIII containing medicament of increased activity. The inventive compounds can furthermore be used in diagnostic kits and as research tools.