Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: The invention relates, inter alia, to an energy storage device (10) for an electrically powered motor vehicle. A first support element (18) is arranged between one end (20) of a stiffening strut (16) and a battery housing (14). The first support element (18) supports the stiffening strut (16) on the battery housing (14), wherein a cross-section of the first support element (18) increases from the end (20) of the stiffening strut (16) towards the battery housing (14). A second support element (26) is arranged between a battery cell stack end side (13) and the battery housing (14). The second support element (26) supports the battery cell stack (12) on the battery housing (14), wherein a cross-section of the second support element (26) decreases from the battery cell stack end side (13) towards the battery housing (14).

Abstract: The invention relates to a method for determining mechanical stresses (200) in an electrical traction energy store (110) of a motor vehicle (1100). According to one aspect of the device, a device (100) comprises a traction energy store (110) for storing electrical energy having at least one cell module (120), which comprises in each case a housing (122) and a plurality of secondary cells (300) which are arranged in the housing (122) and are electrically conductively connected to a power interface (124) of the cell module (120).

Abstract: A traction energy storage system including multiple electrical energy stores and a system controller. Each of the energy stores includes one or more cell modules electrically connected via busbars, an energy store high-voltage interface connectable to the busbars and an energy store controller controlling the cell modules. Each of the cell modules comprises multiple storage cells and a cell module controller. Each of the cell module controllers is configured to output measured values relating to the storage cells in the respective cell module to the energy store controller. Each of the energy store controllers is configured to take the measured values obtained as a basis for generating signals having electrical characteristic quantities of the respective energy store and at least one limit value for a current through the energy store high-voltage interface of the respective energy store.

Abstract: A method and a device for limiting the current in a temperature-dependent manner of an energy storage device for electrical energy adjusts a maximum permissible charging and/or discharging current of the energy storage device in dependence upon a temperature of the energy storage device, wherein the following steps are performed: determining multiple temperature values of the energy storage device that follow one another chronologically during a prevailing time interval; determining a prevailing mean temperature value of the energy storage device from the determined temperature values of the energy storage device during the prevailing time interval; comparing the determined prevailing mean value with a predetermined desired temperature value; and, if the determined prevailing mean value is greater than the desired temperature value, limiting the maximum permissible charging and/or discharging current of the energy storage device.

Abstract: A method and a device for the open-loop and/or closed-loop control of at least one operating parameter of an energy storage device, the operating parameter influencing a state of aging of the energy storage device, to prevent too great a deviation from a planned serviceable life of the energy storage device. The method includes determining an actual state of health and a desired state of health of the energy storage device, and adjusting an operating parameter range that is permissible for the at least one operating parameter range if a comparison of the actual state of health with the desired state of health demonstrates an increased rate or reduced rate of aging in comparison to the desired state of health, wherein the operating parameter range is adjusted so that the energy storage device is operated at a reduced or an increased rate of aging, respectively.

Abstract: A traction energy storage system including multiple electrical energy stores and a system controller. Each of the energy stores includes one or more cell modules electrically connected via busbars, an energy store high-voltage interface connectable to the busbars and an energy store controller controlling the cell modules. Each of the cell modules comprises multiple storage cells and a cell module controller. Each of the cell module controllers is configured to output measured values relating to the storage cells in the respective cell module to the energy store controller. Each of the energy store controllers is configured to take the measured values obtained as a basis for generating signals having electrical characteristic quantities of the respective energy store and at least one limit value for a current through the energy store high-voltage interface of the respective energy store.

Abstract: A method and a device for the open-loop and/or closed-loop control of at least one operating parameter of an energy storage device, the operating parameter influencing a state of aging of the energy storage device, to prevent too great a deviation from a planned serviceable life of the energy storage device. The method includes determining an actual state of health and a desired state of health of the energy storage device, and adjusting an operating parameter range that is permissible for the at least one operating parameter range if a comparison of the actual state of health with the desired state of health demonstrates an increased rate or reduced rate of aging in comparison to the desired state of health, wherein the operating parameter range is adjusted so that the energy storage device is operated at a reduced or an increased rate of aging, respectively.

Abstract: A method and a device for limiting the current in a temperature-dependent manner of an energy storage device for electrical energy adjusts a maximum permissible charging and/or discharging current of the energy storage device in dependence upon a temperature of the energy storage device, wherein the following steps are performed: determining multiple temperature values of the energy storage device that follow one another chronologically during a prevailing time interval; determining a prevailing mean temperature value of the energy storage device from the determined temperature values of the energy storage device during the prevailing time interval; comparing the determined prevailing mean value with a predetermined desired temperature value; and, if the determined prevailing mean value is greater than the desired temperature value, limiting the maximum permissible charging and/or discharging current of the energy storage device.