Abstract: The invention relates to an anti-theft device configured to be attached to merchandise to be protected the anti-theft device including a housing, which comprises a winding apparatus rotatably arranged therein, at least one securing-loop arrangement designed and intended to loop around the merchandise to be protected such that the anti-theft device can be securely connected to the merchandise to be protected, and a locking mechanism.

Abstract: An air guidance control unit having a frame, which surrounds at least one air opening for air flowing along an air flow direction to flow through, a closing device including adjustable flaps, which closing device can be adjusted by means of an adjusting element between an open position in which the air opening is exposed and a closed position in which the air opening is at least partly closed. The invention devises various solutions for especially compact and reliable flap arrangements.

Abstract: A system for electro-writing of a polymer melt comprises a print-head and a feed mechanism configured to controllably feed solid polymer base material towards the print-head, wherein the print-head comprises a nozzle, a heater and an insulating spacer, wherein the print-head is configured to eject the polymer melt via the nozzle, wherein the nozzle is configured to be held at a selectable electric potential, wherein the heater is arranged in the print-head and proximate the nozzle, wherein the heater is configured to heat the solid polymer base material beyond its melting point to create the polymer melt in the print-head, wherein insulating spacer is arranged between the heater and the nozzle, wherein the insulating spacer electrically insulates the heater and the nozzle, and wherein the insulating spacer is at least partially surrounded by the heater.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: An electrical circuit arrangement includes an inverter, a driver circuit and a protective circuit. The inverter includes a plurality of inverter switching elements each having a drive connection. The drive connection of at least one inverter switching element is connected to the driver circuit via a first switching element of the protective circuit (6). A drive connection of the first switching element is connected to a circuit node, which is connected to a first potential via a resistor and to a second potential via a second switching element.

Abstract: The invention relates to an actuator element (10), comprising an actuator (12), which comprises a shape memory alloy and is designed to shorten or extend itself in the longitudinal extension direction thereof when in an excited state; an electronic control unit, which has a carrier element (18) and a plurality of electronic components (26) for exciting the actuator (12) on the basis of a control signal; and a movable component (20), which is coupled to the actuator and is movable by means of the actuator (12) relative to the carrier element (18); wherein the carrier element (18) defines a guide portion (16), in particular a dimensionally stable guide portion, by means of which the actuator (12) is guided along the longitudinal extension direction thereof.

Abstract: The invention relates to an anti-theft device comprising a housing, which is configured to be displaceably mounted to an anti-theft box, which anti-theft box is configured to receive merchandise to be protected, the housing being further configured to selectively take a releasing position, in which the anti-theft box is transferable from a closed state into an opened state, and a locking position, in which the anti-theft box is not transferable from the closed state into the opened state, a locking mechanism associated with the housing and having an unlocked state, in which the housing is displaceable from the locking position into the releasing position, and a locked state, in which the housing is not displaceable from the locking position into the releasing position.

Abstract: The present invention relates to compounds comprising two biguanidyl radicals that can be useful as anti-inflammatory agent, and also to new compounds comprising two biguanidyl radicals and their use as a drug, in particular for treating a cancer, a metabolic disease, a secondary mitochondrial disorder due to copper overload including Indian childhood cirrhosis, Wilson's disease and Idiopathic infantile copper toxicosis or due to iron overload, an infection by a virus such as a coronavirus or an influenza virus, a neurodegenerative disease or disorder and aging.

Abstract: The present invention relates to a system, comprising a lock unit for a cabinet and at least one portable user terminal, the at least one user terminal comprising an interface unit for receiving input commands by the user, a communication unit for at least wirelessly transmitting a release command to the lock unit, and a control unit operatively coupled with the interface unit, the communication unit and a storage unit, wherein the storage unit is adapted to store a unique identifier of the user terminal, wherein the control unit is adapted to create the release command based on input commands in such a manner that it includes the unique identifier; the lock unit comprising a plug unit which is adapted to be transferable between a release position and a locking position, wherein in the release position, opening of the cabinet is enabled, and in the locking position, opening of the cabinet is prohibited, an operation unit adapted for manual operation by the user, which is adapted to transfer the plug unit from

Abstract: A charging apparatus for vending-related devices is provided, comprising a charging compartment, which is adapted to house a plurality of vending-related devices in an unsorted manner; an inlet opening for inserting vending-related devices into the charging apparatus; and a wireless charging unit which is adapted to wirelessly transmit power to vending-related devices currently housed in the at least one charging compartment during charging operation. Furthermore, the invention relates to a system for charging vending-related devices, comprising such a charging apparatus and a vending-related device. Also, a method for charging the vending-related device of such a system is provided.

Abstract: A system for storage of goods carriers with a rack having storage shelves for the goods carriers on multiple levels, with a rack-servicing machine for storage of goods carriers into the storage shelves and for discharge of goods carriers from the storage shelves. The rack-servicing machine runs along tracks extending the longitudinal extension of the rack, preferably in an aisle between two racks, and is configured to service at least one level, where the goods carriers have at least two pockets correspondingly located in respective opposite side walls configured to allow interaction with the load handler of the rack-servicing machine.

Abstract: Aspects of the invention relate to a high-power switching module for the direct pulse energy feeding of a consumer with a plurality of switching stages connected in series. A coupling element and an energy buffer store are provided, the coupling element coupling a primary circuit comprising a balancing capacitance and a semiconductor switch to a secondary circuit comprising the energy buffer store, the coupling element being provided and embodied for obtaining energy of the balancing capacitance and delivering this energy to the energy buffer store during the on phase of the semiconductor switch, and the energy buffer store being provided and embodied for delivering the obtained energy to an energy store of the driver assembly when the semiconductor switch is in the switched-off state.

Abstract: A system for storage of goods carriers with a rack having storage shelves for the goods carriers on multiple levels, with a rack—servicing machine for storage of goods carriers into the storage shelves and for discharge of goods carriers from the storage shelves. The rack-servicing machine runs along tracks extending the longitudinal extension of the rack, preferably in an aisle between two racks, and is configured to service at least one level, where the storage shelves are formed with ledgers having guide strips.

Abstract: A converter has module devices each with a series connection of at least two partial modules being electrically connected in series. A central device is configured to switch module control devices, in which a sum of the transmitted voltage values or the transmitted sum value reaches a predefined voltage threshold, into a second charging phase of a charging operation by transmitting a first voltage specification relating to switched-off partial modules and a second voltage specification relating to switched-on partial modules to the module control devices. The module devices are configured to meet the first and second voltage specifications by setting none, one or more of the communication-capable partial modules thereof into a switched-on operating state and none, one or more of the other communication-capable partial modules thereof into a switched-off operating state, and to continue the charging of the energy stores which are in the switched-on and blocked operating state.

Abstract: The invention relates to an anti-theft device (100) configured for being attached to merchandise to be protected, in particular textile products, wherein the anti-theft device (100) comprises a housing (102) and a locking mechanism (130), which has a needle (106), wherein the needle (106) is adjustable between a locking position, in which it engages with the merchandise to be protected, and a release position, in which detachment and removal of the anti-theft device (100) from the merchandise to be protected are permitted, wherein the needle (106) has a curved, preferably arcuate shape and is accommodated in the housing (102) when in the release position.

Abstract: A first functionality of anti-theft security system infrastructure provides at least signal reception capabilities and enables the anti-theft security system infrastructure to detect mobile anti-theft devices by receiving advertising signals therefrom and to hand over a respectively detected mobile anti-theft device to a second functionality of the anti-theft security system infrastructure, wherein the second functionality provides at least signal transmission capabilities and enables the anti-theft security system infrastructure to communicate with an handed-over mobile anti-theft device including the sending of a release command to the handed-over anti-theft device, automatically after the handing-over or if at least one release condition is fulfilled.

Abstract: A sensor apparatus is provided in which both an optical interrogator and an optical waveguide are embedded in the same component made of fiber-reinforced plastic. The optical interrogator and the optical waveguide thus form a unit with the component made of fiber-reinforced plastic, in which they are embedded. The optical interrogator and the optical waveguide are arranged in this case protected in the same component made of fiber-reinforced plastic. The optical waveguide does not have to be led out of this component and into the interrogator. The risk of damage to the optical waveguide is thus significantly reduced.

Abstract: The invention relates to methods and pharmaceutical compositions for the treatment of Cytokine Release Syndrome (CRS). The invention also relates to methods for the diagnosis of patients suffering from Cytokine Release Syndrome. The inventors investigate iron homeostasis and the role of CD44-mediated iron endocytosis in the severe inflammatory response and Cytokine Release Syndrome, particularly in SARS-CoV-2 patients. The inventors demonstrate that during activation of M1 macrophages, iron endocytosis is upregulated in a CD44-dependent manner and that CD44 protein levels increase. This effect is specific to M1 macrophages, whereas levels of the canonical iron endocytosis protein TfR1/CD71 remain unchanged. In the present invention, the inventors provide in vitro evidences towards a direct role of CD44-mediated iron endocytosis in the severe inflammatory response such as Cytokine Release Syndrome observed in SARS-CoV-2 patients.

Abstract: The invention relates to an anti-theft device configured to be attached to merchandise to be protected, preferably to cardboard boxes, the anti-theft device comprising a housing, which comprises a winding apparatus rotatably mounted therein, at least one securing-loop arrangement, the securing-loop arrangement being designed to loop around the merchandise to be protected such that the anti-theft device can be securely connected to the merchandise to be protected, and a winding apparatus locking mechanism configured to prevent the rotational unwinding movement of the winding apparatus in the housing, if the winding apparatus locking mechanism is engaged with the winding apparatus.

Abstract: Disclosed is a product anti-theft system having a product anti-theft device configured to be attached to a product to be secured, the anti-theft device having a housing with a connecting portion designed to be connected to the product to be secured and a locking mechanism associated with the connecting portion and having a secured state and a released state. The anti-theft system further includes a release device for transmitting a release signal that triggers transferring of the locking mechanism from the secured state to the released state. Also disclosed is a method of operating an anti-theft device.