Abstract: A system includes a medical device and computer-readable media storing instructions that, when executed by a processor, cause operations to be performed, including: receiving a three-dimensional (3D) image of anatomy, processing the 3D image to extract a 3D model identifying anatomical structures of interest, receiving images captured by an imaging device of the medical device as the medical device is navigated through a body lumen to a target site, including a current image of the target site, receiving medical device spatial information from a position sensing system including a transmitter/receiver in or on the medical device, processing the images and spatial information to generate a 3D surface map of the body lumen, registering the 3D model to the patient using the map and spatial information, and generating and displaying a graphical user interface overlaying a representation of a position/trajectory of the anatomical structures of interest on the current image.

Abstract: Medical imaging reconstruction of a subject's anatomy may include: monitoring first and second medical imaging data of the subject's anatomy, wherein: the first medical imaging data is captured from within the subject's anatomy by at least one first medical imaging device; the second medical imaging data is captured from outside of the subject's anatomy by at least one second medical imaging device; and at least one of the first medical imaging device or the second medical imaging device is operable to selectively target different regions of the subject's anatomy; and in response to detecting, based on the monitoring, a divergence in the first medical imaging data and the second medical imaging data above a predetermined threshold, updating a medical imaging reconstruction of the subject's anatomy that is based on the first medical imaging data and the second medical imaging data.

Abstract: A medical device is described that may include a handle and a needle extending distally from the handle. The needle may be configured to be at least partially inserted into a body, and may include a sheath and a core disposed in the sheath. The core may have a distal portion including a distal tip, and a proximal portion distinct from the distal portion. A proximal end of the distal portion may be coupled to a distal end of the proximal portion to define a cavity between the proximal end of the distal portion and the distal end of the proximal portion. The needle may further include a device of a position sensing system arranged in the cavity. The device may be a transmitter device or a receiver device. The position sensing system may be configured to determine a position or an orientation of the distal tip.

Abstract: Medical systems are described, including a medical system includes a first medical device and a second medical device. The first medical device includes a handle and an insertion portion with a first working channel. A distal portion of the insertion portion of the first medical device includes a first tracking element and at least one camera. The second medical device includes a handle and an insertion portion. A distal portion of the insertion portion of the second medical device includes a second tracking element. The first tracking element is configured to provide a signal that indicates a position or orientation of the distal portion of the first medical device. The second tracking element is configured to provide a signal that indicates a position or orientation of the distal portion of the second medical device.

Abstract: A method of providing in vivo navigation of a medical device includes: receiving input medical imaging data of a patient's anatomy; receiving input non-optical in vivo image data from a sensor on a distal end of the device in the anatomy; using a trained model to locate the distal end in the input imaging data, wherein: the model is trained, based on (i) training medical imaging data and training non-optical in vivo image data of one or more individuals' anatomy and (ii) registration data associating the training image data with locations in the training imaging data as ground truth, to learn associations between the training image data and the training imaging data; determining an output location of the medical device using the learned associations and the input data; modifying the input imaging data to depict the determined location; and causing a display to output the modified input imaging data.

Abstract: The disclosure relates to localizing medical devices within a body lumen, such as for identifying the location of, or navigating to, a target tissue. Embodiments include localizing a medical device extended out of a working channel of a delivery device. The medical device may include an imaging sensor, such as for mapping the body lumen. In many embodiments, a delivery device may include one or more sensors including a first sensor to interact with a tracking system to determine the location of the delivery device within a tracking volume and a second sensor to determine the location of the medical device relative to the delivery device. In many such embodiments, a controller may determine the location of the medical device in the tracking volume based on the location of the delivery device in the tracking volume and the location of the medical device with respect to the delivery device.