Patents by Inventor Sebastian RABE

Sebastian RABE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing quinolin-2-yl-phenylamine derivatives and their salts
    Patent number: 10745357
    Abstract: The present invention relates (i) to a process for the preparation of quinolin-2-yl-phenylamine derivatives of formula (I) without a metal catalyst, and (ii) to soluble mineral acid or sulfonic acid salts of (8-chloro-quinolin-2-yl)-(4-trifluoromethoxyphenyl)-amine.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: August 18, 2020
    Inventors: Sebastian Rabe, Wolfgang Albrecht
  • Methods of preparing co-crystals of ibrutinib with carboxylic acids
    Patent number: 10669275
    Abstract: The present invention relates to co-crystals of ibrutinib and a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: June 2, 2020
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Jens Geier, Sebastian Rabe, David Perez Palacios
  • Process for Preparing Quinolin-2-yl-phenylamine Derivatives and their Salts
    Publication number: 20200062713
    Abstract: The present invention relates (i) to a process for the preparation of quinolin-2-yl-phenylamine derivatives of formula (I) without a metal catalyst, and (ii) to soluble mineral acid or sulfonic acid salts of (8-chloro-quinolin-2-yl)-(4-trifluoromethoxyphenyl)-amine.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Inventors: Sebastian RABE, Wolfgang ALBRECHT
  • Process for preparing quinolin-2-yl-phenylamine derivatives and their salts
    Patent number: 10464903
    Abstract: The present invention relates (i) to a process for the preparation of quinolin-2-yl-phenylamine derivatives of formula (I) without a metal catalyst, and (ii) to soluble mineral acid or sulfonic acid salts of (8-chloro-quinolin-2-yl)-(4-trifluoromethoxyphenyl)-amine.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: November 5, 2019
    Assignee: RATIOPHARM GMBH
    Inventors: Sebastian Rabe, Wolfgang Albrecht
  • Co-crystals of ibrutinib with carboxylic acids
    Patent number: 10377758
    Abstract: The present invention relates to co-crystals of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 13, 2019
    Assignee: Ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Jens Geier, Sebastian Rabe, David Perez Palacios
  • METHODS OF PREPARING CO-CRYSTALS OF IBRUTINIB WITH CARBOXYLIC ACIDS
    Publication number: 20190225616
    Abstract: The present invention relates to co-crystals of ibrutinib and a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Application
    Filed: November 28, 2018
    Publication date: July 25, 2019
    Applicant: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Jens Geier, Sebastian Rabe, David Perez Palacios
  • Process for Preparing Quinolin-2-yl-phenylamine Derivatives and their Salts
    Publication number: 20190077760
    Abstract: The present invention relates (i) to a process for the preparation of quinolin-2-yl-phenylamine derivatives of formula (I) without a metal catalyst, and (ii) to soluble mineral acid or sulfonic acid salts of (8-chloro-quinolin-2-yl)-(4-trifluoromethoxyphenyl)-amine.
    Type: Application
    Filed: March 20, 2017
    Publication date: March 14, 2019
    Inventors: Sebastian RABE, Wolfgang ALBRECHT
  • Acid addition salt of ibrutinib
    Patent number: 10059715
    Abstract: The present invention relates to acid addition salts of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: August 28, 2018
    Assignee: Ratiopharm GmbH
    Inventors: Sebastian Rabe, Manfred Erdmann, Wolfgang Albrecht
  • CO-CRYSTALS OF IBRUTINIB WITH CARBOXYLIC ACIDS
    Publication number: 20180072737
    Abstract: The present invention relates to co-crystals of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 15, 2018
    Applicant: ratiopharm GmbH
    Inventors: Wolfgang ALBRECHT, Jens GEIER, Sebastian RABE, David PEREZ PALACIOS
  • Prodrugs of monomethyl fumarate (MMF)
    Patent number: 9868690
    Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 16, 2018
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Richard Guserle, Annemarie Maier
  • ACID ADDITION SALT OF IBRUTINIB
    Publication number: 20170305914
    Abstract: The present invention relates to acid addition salts of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Application
    Filed: August 25, 2015
    Publication date: October 26, 2017
    Applicant: ratiopharm GmbH
    Inventors: Sebastian RABE, Manfred ERDMANN, Wolfgang ALBRECHT
  • Derivatives of polyhydroxy compounds
    Patent number: 9796659
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: October 24, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Frank Lehmann, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • BIS-MMF derivatives
    Patent number: 9663480
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: May 30, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • Derivatives of tartaric acid
    Patent number: 9593068
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: March 14, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • DERIVATIVES OF POLYHYDROXY COMPOUNDS
    Publication number: 20170001945
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 5, 2017
    Inventors: Wolfgang ALBRECHT, Frank LEHMANN, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE
  • DERIVATIVES OF TARTARIC ACID
    Publication number: 20160326090
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 4, 2014
    Publication date: November 10, 2016
    Applicant: RATIOPHARM GMBH
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE
  • BIS-MMF DERIVATIVES
    Publication number: 20160289201
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 4, 2014
    Publication date: October 6, 2016
    Applicant: Ratiopharm GMBH
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE
  • PRODRUGS OF MONOMETHYL FUMARATE (MMF)
    Publication number: 20160214948
    Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 28, 2016
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Richard GUSERLE, Annemarie MAIER
  • PRODRUGS OF MONOMETHYL FUMARATE (MMF)
    Publication number: 20150299103
    Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 20, 2013
    Publication date: October 22, 2015
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Richard GUSERLE, Annemarie MAIER